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    Academic Journals

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• Intermittent glucocorticoid treatment enhances skeletal muscle performance through sexually dimorphic mechanisms.

  Authors:Isabella M. Salamone, Mattia Quattrocelli, David Y. Barefield, Patrick G. Page, Ibrahim Tahtah, Michele Hadhazy, et al.From:Journal of Clinical Investigation (Vol. 132, Issue 6) Peer-Reviewed

  Mar. 15, 202211,851 words Report 1420LGlucocorticoid steroids are commonly prescribed for many inflammatory conditions, but chronic daily use produces adverse effects, including muscle wasting and weakness. In contrast, shorter glucocorticoid pulses may...

• Retraction: CD155 loss enhances tumor suppression via combined host and tumor-intrinsic mechanisms.

  Authors:Xian-Yang Li, Indrajit Das, Ailin Lepletier, Venkateswar Addala, Tobias Bald, Kimberley Stannard, et al.From:Journal of Clinical Investigation (Vol. 132, Issue 6) Peer-Reviewed

  Mar. 15, 202293 words Brief article 990LOriginal citation: J Clin Invest. 2018;128(6):2613-2625. https://doi.org/10.1172/JCI98769. Citation for this retraction: J Clin Invest. 2022;132(6):e159825. https://doi.org/10.1172/JCI159825. QIMR Berghofer Medical...

• Targeting the NANOG/HDAC1 axis reverses resistance to PD-1 blockade by reinvigorating the antitumor immunity cycle.

  Authors:Se Jin Oh, Hyo-Jung Lee, Kwon-Ho Song, Suyeon Kim, Eunho Cho, Jaeyoon Lee, et al.From:Journal of Clinical Investigation (Vol. 132, Issue 6) Peer-Reviewed

  Mar. 15, 202210,334 words Report 1450LImmune checkpoint blockade (ICB) therapy has shifted the paradigm for cancer treatment. However, the majority of patients lack effective responses because of the emergence of immune-refractory tumors that disrupt the...

• B cell receptor signaling strength modulates cancer immunity.

  Authors:Jian Ye and Peter P. LeeFrom:Journal of Clinical Investigation (Vol. 132, Issue 6) Peer-Reviewed

  Mar. 15, 20222,059 words Article 1490LTumor-infiltrating B cells exert antitumor effects by producing antibodies against tumor-associated antigens. Conversely, B cells may promote tumors through the production of factors that dampen antitumor immunity. In...

• Metronidazole treatment rapidly reduces genital inflammation through effects on bacterial vaginosis-associated bacteria rather than lactobacilli.

  Authors:Eric Armstrong, Anke Hemmerling, Steve Miller, Kerianne E. Burke, Sara J. Newmann, Sheldon R. Morris, et al.From:Journal of Clinical Investigation (Vol. 132, Issue 6) Peer-Reviewed

  Mar. 15, 20225,496 words Report 1540LBACKGROUND. Bacterial vaginosis (BV) causes genital inflammation and increases HIV risk, whereas a vaginal microbiota dominated by Lactobacillus species is associated with immune quiescence and relative HIV protection....

• An Asia-specific variant of human IgG1 represses colorectal tumorigenesis by shaping the tumor microenvironment.

  Authors:Bing Yang, Zhen Zhang, Xiangjun Chen, Xu-Yan Wang, Shishang Qin, Liaoqi Du, et al.From:Journal of Clinical Investigation (Vol. 132, Issue 6) Peer-Reviewed

  Mar. 15, 202211,216 words Report 1520LEmerging studies have focused on ways to treat cancers by modulating T cell activation. However, whether B cell receptor signaling in the tumor microenvironment (TME) can be harnessed for immunotherapy is unclear. Here,...

• YAP mediates compensatory cardiac hypertrophy through aerobic glycolysis in response to pressure overload.

  Authors:Toshihide Kashihara, Risa Mukai, Shin-Ichi Oka, Peiyong Zhai, Yasuki Nakada, Zhi Yang, et al.From:Journal of Clinical Investigation (Vol. 132, Issue 6) Peer-Reviewed

  Mar. 15, 202210,928 words Report 1460LThe heart utilizes multiple adaptive mechanisms to maintain pump function. Compensatory cardiac hypertrophy reduces wall stress and oxygen consumption, thereby protecting the heart against acute blood pressure elevation....

• Arginine deprivation alters microglial polarity and synergizes with radiation to eradicate non-arginine-auxotrophic glioblastoma tumors.

  Authors:Nabil Hajji, Juan Garcia-Revilla, Manuel Sarmiento Soto, Richard Perryman, Jake Symington, Chad C. Quarles, et al.From:Journal of Clinical Investigation (Vol. 132, Issue 6) Peer-Reviewed

  Mar. 15, 202210,761 words Report 1410LNew approaches for the management of glioblastoma (GBM) are an urgent and unmet clinical need. Here, we illustrate that the efficacy of radiotherapy for GBM is strikingly potentiated by concomitant therapy with the...

• A CGA/EGFR/GATA2 positive feedback circuit confers chemoresistance in gastric cancer.

  Authors:Tianyu Cao, Yuanyuan Lu, Qi Wang, Hongqiang Qin, Hongwei Li, Hao Guo, et al.From:Journal of Clinical Investigation (Vol. 132, Issue 6) Peer-Reviewed

  Mar. 15, 202211,547 words Report 1380LDe novo and acquired resistance are major impediments to the efficacy of conventional and targeted cancer therapy. In unselected gastric cancer (GC) patients with advanced disease, trials combining chemotherapy and an...

• High-dose rifampin improves bactericidal activity without increased intracerebral inflammation in animal models of tuberculous meningitis.

  Authors:Camilo A. Ruiz-Bedoya, Filipa Mota, Elizabeth W. Tucker, Farina J. Mahmud, Maria I. Reyes-Mantilla, Clara Erice, et al.From:Journal of Clinical Investigation (Vol. 132, Issue 6) Peer-Reviewed

  Mar. 15, 20228,652 words Report 1450LTuberculous meningitis (TB meningitis) is the most severe form of tuberculosis (TB), requiring 12 months of multidrug treatment for cure, and is associated with high morbidity and mortality. High-dose rifampin (35...

• ADAR1-mediated RNA editing links ganglioside catabolism to glioblastoma stem cell maintenance.

  Authors:Li Jiang, Yajing Hao, Changwei Shao, Qiulian Wu, Briana C. Prager, Ryan C. Gimple, et al.From:Journal of Clinical Investigation (Vol. 132, Issue 6) Peer-Reviewed

  Mar. 15, 202210,925 words Report 1360LGlioblastoma (GBM) is the most common and lethal primary malignant brain tumor, containing GBM stem cells (GSCs) that contribute to therapeutic resistance and relapse. Exposing potential GSC vulnerabilities may provide...

• Genetically programmed alternative splicing of NEMO mediates an autoinflammatory disease phenotype.

  Authors:Younglang Lee, Alex W. Wessel, Jiazhi Xu, Julia G. Reinke, Eries Lee, Somin M. Kim, et al.From:Journal of Clinical Investigation (Vol. 132, Issue 6) Peer-Reviewed

  Mar. 15, 202211,907 words Report 1530LHost defense and inflammation are regulated by the NF-[kappa]B essential modulator (NEMO), a scaffolding protein with a broad immune cell and tissue expression profile. Hypomorphic mutations in inhibitor of NF-[kappa]B...

• Tumor-specific interendothelial adhesion mediated by FLRT2 facilitates cancer aggressiveness.

  Authors:Tomofumi Ando, Ikue Tai-Nagara, Yuki Sugiura, Dai Kusumoto, Koji Okabayashi, Yasuaki Kido, et al.From:Journal of Clinical Investigation (Vol. 132, Issue 6) Peer-Reviewed

  Mar. 15, 20228,958 words Report 1300LBlood vessel abnormalization alters cancer cell metabolism and promotes cancer dissemination and metastasis. However, the biological features of the abnormalized blood vessels that facilitate cancer progression and...

• Use of host lipids by the Lyme disease spirochete may lead to biomarkers.

  Authors:Gunjan Arora, Thomas Hart, and Erol FikrigFrom:Journal of Clinical Investigation (Vol. 132, Issue 6) Peer-Reviewed

  Mar. 15, 20221,768 words Article 1390LLyme disease is the most common tick-borne disease in North America and Europe, however, current biomarkers inconsistently detect the disease. In this issue of the JC!, Gwynne et al. revealed how the Lyme disease agent...

• Targeting the vasculature in cardiometabolic disease.

  Authors:Nabil E. Boutagy, Abhishek K. Singh, and William C. SessaFrom:Journal of Clinical Investigation (Vol. 132, Issue 6) Peer-Reviewed

  Mar. 15, 202210,923 words Report 1410LObesity has reached epidemic proportions and is a major contributor to insulin resistance (IR) and type 2 diabetes (T2D). Importantly, IR and T2D substantially increase the risk of cardiovascular (CV) disease. Although...

• SARS-CoV-2 infection and vaccination trigger long-lived B and [CD4.sup.+] T lymphocytes with implications for booster strategies.

  Authors:Alessio Mazzoni, Anna Vanni, Michele Spinicci, Giulia Lamacchia, Seble Tekle Kiros, Arianna Rocca, et al.From:Journal of Clinical Investigation (Vol. 132, Issue 6) Peer-Reviewed

  Mar. 15, 20227,377 words Report 1570LBACKGROUND. Immunization against SARS-CoV-2, the causative agent of COVID-19, occurs via natural infection or vaccination. However, it is currently unknown how long infection- or vaccination-induced immunological memory...

• YAP: The nexus between metabolism and cardiac Remodeling.

  Authors:Chen Gao and Yibin WangFrom:Journal of Clinical Investigation (Vol. 132, Issue 6) Peer-Reviewed

  Mar. 15, 20221,902 words Article 1540LCardiomyocyte hypertrophy is an integral part of cardiac remodeling that occurs under physiological or pathological stresses. It can lead to heart failure in a pathological form or oppose functional deterioration in a...

• Sortilin restricts secretion of apolipoprotein B-100 by hepatocytes under stressed but not basal conditions.

  Authors:Donna M. Conlon, Carolin V. Schneider, Yi-An Ko, Amrith Rodrigues, Kathy Guo, Nicholas J. Hand, et al.From:Journal of Clinical Investigation (Vol. 132, Issue 6) Peer-Reviewed

  Mar. 15, 202211,048 words Report 1440LGenetic variants at the SORT1 locus in humans, which cause increased SORT1 expression in the liver, are significantly associated with reduced plasma levels of LDL cholesterol and apolipoprotein B (apoB). However, the...

• Antiphospholipid autoantibodies in Lyme disease arise after scavenging of host phospholipids by Borrelia burgdorferi.

  Authors:Peter J. Gwynne, Luke H. Clendenen, Siu-Ping Turk, Adriana R. Marques, and Linden T. HuFrom:Journal of Clinical Investigation (Vol. 132, Issue 6) Peer-Reviewed

  Mar. 15, 20228,857 words Report 1360LA close association with its vertebrate and tick hosts allows Borrelia burgdorferi, the bacterium responsible for Lyme disease, to eliminate many metabolic pathways and instead scavenge key nutrients from the host. A...

• Lysosomal exocytosis of HSP70 stimulates monocytic BMP6 expression in Sjogren's syndrome.

  Authors:Ying-Qian Mo, Hiroyuki Nakamura, Tsutomu Tanaka, Toshio Odani, Paola Perez, Youngmi Ji, et al.From:Journal of Clinical Investigation (Vol. 132, Issue 6) Peer-Reviewed

  Mar. 15, 20229,283 words Report 1380LBMP6 is a central cytokine in the induction of Sjogren's syndrome-associated (SS-associated) secretory hypofunction. However, the upstream initiation leading to the production of this cytokine in SS is unknown. In this...