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    Academic Journals

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• An acid trip activates protumoral macrophages to promote hepatocellular carcinoma malignancy.

  Authors:Nicola Graham and Jeffrey W. PollardFrom:Journal of Clinical Investigation (Vol. 132, Issue 7) Peer-Reviewed

  Apr. 1, 20222,324 words Article 1390LTumor-associated macrophages (TAMs) promote metastasis and tumor cell extravasation, survival, and growth. In hepatocellular carcinoma (HCC), the presence of TAM subpopulations correlates with poor outcome. In this issue...

• Single-cell RNA sequencing reveals induction of distinct trained-immunity programs in human monocytes.

  Authors:Bowen Zhang, Simone J.C.F.M Moorlag, Jorge Dominguez-Andres, Ozlem Bulut, Gizem Kilic, Zhaoli Liu, et al.From:Journal of Clinical Investigation (Vol. 132, Issue 7) Peer-Reviewed

  Apr. 1, 202211,314 words Report 1500LTrained immunity refers to the long-lasting memory traits of innate immunity. Recent studies have shown that trained immunity is orchestrated by sustained changes in epigenetic marks and metabolic pathways, leading to an...

• Anti-CD45RC antibody immunotherapy prevents and treats experimental autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy syndrome.

  Authors:Marine Besnard, Celine Serazin, Jason Ossart, Anne Moreau, Nadege Vimond, Lea Flippe, et al.From:Journal of Clinical Investigation (Vol. 132, Issue 7) Peer-Reviewed

  Apr. 1, 202210,952 words Report 1520LTargeted monoclonal antibody (mAb) therapies show great promise for the treatment of transplant rejection and autoimmune diseases by inducing more specific immunomodulatory effects than broadly immunosuppressive drugs...

• Sec13 promotes oligodendrocyte differentiation and myelin repair through autocrine pleiotrophin signaling.

  Authors:Zhixiong Liu, Minbiao Yan, Wanying Lei, Rencai Jiang, Wenxiu Dai, Jialin Chen, et al.From:Journal of Clinical Investigation (Vol. 132, Issue 7) Peer-Reviewed

  Apr. 1, 202210,770 words Report 1290LDysfunction of protein trafficking has been intensively associated with neurological diseases, including neurodegeneration, but whether and how protein transport contributes to oligodendrocyte (OL) maturation and myelin...

• Tankyrase represses autoinflammation through the attenuation of TLR2 signaling.

  Authors:Yoshinori Matsumoto, Ioannis D. Dimitriou, Jose La Rose, Melissa Lim, Susan Camilleri, Napoleon Law, et al.From:Journal of Clinical Investigation (Vol. 132, Issue 7) Peer-Reviewed

  Apr. 1, 20229,787 words Report 1470LDysregulation of Toll-like receptor (TLR) signaling contributes to the pathogenesis of autoimmune diseases. Here, we provide genetic evidence that tankyrase, a member of the poly(ADP-ribose) polymerase (PARP) family,...

• Next-generation sequencing: insights to advance clinical investigations of the microbiome.

  Authors:Caroline R. Wensel, Jennifer L. Pluznick, Steven L. Salzberg, and Cynthia L. SearsFrom:Journal of Clinical Investigation (Vol. 132, Issue 7) Peer-Reviewed

  Apr. 1, 20229,038 words Report 1370LNext-generation sequencing (NGS) technology has advanced our understanding of the human microbiome by allowing for the discovery and characterization of unculturable microbes with prediction of their function. Key NGS...

• IL-9/STAT3/fatty acid oxidation-mediated lipid peroxidation contributes to Tc9 cell longevity and enhanced antitumor activity.

  Authors:Liuling Xiao, Xingzhe Ma, Lingqun Ye, Pan Su, Wei Xiong, Enguang Bi, et al.From:Journal of Clinical Investigation (Vol. 132, Issue 7) Peer-Reviewed

  Apr. 1, 202211,534 words Report 1490L[CD8.sup.+] T cell longevity regulated by metabolic activity plays important roles in cancer immunotherapy. Although in vitropolarized, transferred IL-9-secreting [CD8.sup.+] Tc9 (cytotoxic T lymphocyte subset 9) cells...

• Ataxia-linked SLC1A3 mutations alter EAAT1 chloride channel activity and glial regulation of CNS function.

  Authors:Qianyi Wu, Azman Akhter, Shashank Pant, Eunjoo Cho, Jin Xin Zhu, Alastair Garner, et al.From:Journal of Clinical Investigation (Vol. 132, Issue 7) Peer-Reviewed

  Apr. 1, 202211,430 words Report 1510LGlutamate is the predominant excitatory neurotransmitter in the mammalian central nervous system (CNS). Excitatory amino acid transporters (EAATs) regulate extracellular glutamate by transporting it into cells, mostly...

• Peter Tontonoz honored with the 2022 ASCI/Stanley J. Korsmeyer Award.

  Author:Elyse DankoskiFrom:Journal of Clinical Investigation (Vol. 132, Issue 7) Peer-Reviewed

  Apr. 1, 20222,017 words Interview 1150LThe American Society for Clinical Investigation (ASCI) has selected Peter Tontonoz to receive 2022's Stanley J. Korsmeyer Award, recognizing his foundational discoveries in lipid metabolism and his dedication to...

• The HIV-1 proviral landscape reveals that Nef contributes to HIV-1 persistence in effector memory [CD4.sup.+] T cells.

  Authors:Gabriel Duette, Bonnie Hiener, Hannah Morgan, Fernando G. Mazur, Vennila Mathivanan, Bethany A. Horsburgh, et al.From:Journal of Clinical Investigation (Vol. 132, Issue 7) Peer-Reviewed

  Apr. 1, 202211,899 words Report 1400LDespite long-term antiretroviral therapy (ART), HIV-1 persists within a reservoir of [CD4.sup.+] T cells that contribute to viral rebound if treatment is interrupted. Identifying the cellular populations that contribute...

• Lessons learned: next-generation sequencing applied to undiagnosed genetic diseases.

  Authors:Bryce A. Schuler, Erica T. Nelson, Mary Koziura, Joy D. Cogan, Rizwan Hamid, and John A. Phillips, IIIFrom:Journal of Clinical Investigation (Vol. 132, Issue 7) Peer-Reviewed

  Apr. 1, 20227,655 words Report 1370LRare genetic disorders, when considered together, are relatively common. Despite advancements in genetics and genomics technologies as well as increased understanding of genomic function and dysfunction, many genetic...

• Training can't always lead to Olympic macrophages.

  Authors:Erwan Pernet, Renaud Prevel, and Maziar DivangahiFrom:Journal of Clinical Investigation (Vol. 132, Issue 7) Peer-Reviewed

  Apr. 1, 20222,177 words Article 1470LAlthough the memory capacity of innate immune cells, termed trained immunity (TI), is a conserved evolutionary trait, the cellular and molecular mechanisms involved are incompletely understood. One fundamental question...

• Direct cellular reprogramming enables development of viral T antigen-driven Merkel cell carcinoma in mice.

  Authors:Monique E. Verhaegen, Paul W. Harms, Julia J. Van Goor, Jacob Arche, Matthew T. Patrick, Dawn Wilbert, et al.From:Journal of Clinical Investigation (Vol. 132, Issue 7) Peer-Reviewed

  Apr. 1, 20224,150 words Report 1570LMerkel cell carcinoma (MCC) is an aggressive neuroendocrine skin cancer that frequently carries an integrated Merkel cell polyomavirus (MCPyV) genome and expresses viral transforming antigens (TAgs). MCC tumor cells also...

• Targeting TGF-[beta] for treatment of osteogenesis imperfecta.

  Authors:I-Wen Song, Sandesh C.S. Nagamani, Dianne Nguyen, Ingo Grafe, Vernon Reid Sutton, Francis H. Gannon, et al.From:Journal of Clinical Investigation (Vol. 132, Issue 7) Peer-Reviewed

  Apr. 1, 20227,381 words Report 1410LBACKGROUND. Currently, there is no disease-specific therapy for osteogenesis imperfecta (OI). Preclinical studies demonstrate that excessive TGF-[beta] signaling is a pathogenic mechanism in OI. Here, we evaluated...

• The FoxOs are in the ApoM house.

  Authors:MacRae F. Linton, Patricia G. Yancey, Zoe M. Leuthner, and Jonathan D. BrownFrom:Journal of Clinical Investigation (Vol. 132, Issue 7) Peer-Reviewed

  Apr. 1, 20222,889 words Article 1430LThe prevalence of metabolic syndrome continues to increase globally and heightens the risk for cardiovascular disease (CVD). Insulin resistance is a core pathophysiologic mechanism that causes abnormal carbohydrate...

• Hide and seek: for HIV-infected [CD4.sup.+] T cells, playing well comes with maturity.

  Authors:Louise Leyre and R. Brad JonesFrom:Journal of Clinical Investigation (Vol. 132, Issue 7) Peer-Reviewed

  Apr. 1, 20222,879 words Article 1570LAntiretroviral therapy suppresses HIV replication but leaves a population of infected [CD4.sup.+] T cells with integrated proviruses. While most of these proviruses contain defects, such as deletions, some intact...

• Carbonic anhydrase XII mediates the survival and prometastatic functions of macrophages in human hepatocellular carcinoma.

  Authors:Wan-Ru Ning, Da Jiang, Xing-Chen Liu, Yu-Fan Huang, Zhi-Peng Peng, Ze-Zhou Jiang, et al.From:Journal of Clinical Investigation (Vol. 132, Issue 7) Peer-Reviewed

  Apr. 1, 202210,605 words Report 1550LMacrophages constitute a major immune component in tumor tissues, but how these cells adapt to and survive in the nutrient-depleted and lactic acid-induced acidic tumor microenvironments is not yet fully understood....

• Hepatic FoxOs link insulin signaling with plasma lipoprotein metabolism through an apolipoprotein M/sphingosine-1-phosphate pathway.

  Authors:Maria Concepcion Izquierdo, Niroshan Shanmugarajah, Samuel X. Lee, Michael J. Kraakman, Marit Westerterp, Takumi Kitamoto, et al.From:Journal of Clinical Investigation (Vol. 132, Issue 7) Peer-Reviewed

  Apr. 1, 202211,172 words Report 1340LMultiple beneficial cardiovascular effects of HDL depend on sphingosine-1-phosphate (S1P). S1P associates with HDL by binding to apolipoprotein M (ApoM). Insulin resistance is a major driver of dyslipidemia and...

• SENP7 senses oxidative stress to sustain metabolic fitness and antitumor functions of [CD8.sup.+] T cells.

  Authors:Zhongqiu Wu, Haiyan Huang, Qiaoqiao Han, Zhilin Hu, Xiao-Lu Teng, Rui Ding, et al.From:Journal of Clinical Investigation (Vol. 132, Issue 7) Peer-Reviewed

  Apr. 1, 20228,126 words Report 1430LThe functional integrity of [CD8.sup.+] T cells is tightly coupled to metabolic reprogramming, but how oxidative stress directs [CD8.sup.+] T cell metabolic fitness in the tumor microenvironment (TME) remains elusive....

• Stromal oncostatin M cytokine promotes breast cancer progression by reprogramming the tumor microenvironment.

  Authors:Angela M. Araujo, Andrea Abaurrea, Peio Azcoaga, Joanna I. Lopez-Velazco, Sara Manzano, Javier Rodriguez, et al.From:Journal of Clinical Investigation (Vol. 132, Issue 7) Peer-Reviewed

  Apr. 1, 202211,476 words Report 1470LThe tumor microenvironment (TME) is reprogrammed by cancer cells and participates in all stages of tumor progression. The contribution of stromal cells to the reprogramming of the TME is not well understood. Here, we...