Search Results

• • 17 

    Academic Journals

  • Sort by: sorttype.publication.date.desc Newest sorttype.publication.date.asc Oldest sorttype.relevance Relevance

• Impact of antigenic evolution and original antigenic sin on SARS-CoV-2 immunity.

  Authors:Muriel Aguilar-Bretones, Ron A.M. Fouchier, Marion P.G. Koopmans, and Gijsbert P. van NieropFrom:Journal of Clinical Investigation (Vol. 133, Issue 1) Peer-Reviewed

  Jan. 20239,083 words Report 1490LInfections with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and vaccinations targeting the spike protein (S) offer protective immunity against coronavirus disease 2019 (COVID-19). This immunity may...

• Macrophages and microglia in glioblastoma: heterogeneity, plasticity, and therapy.

  Authors:Fatima Khan, Lizhi Pang, Madeline Dunterman, Maciej S. Lesniak, Amy B. Heimberger, and Peiwen ChenFrom:Journal of Clinical Investigation (Vol. 133, Issue 1) Peer-Reviewed

  Jan. 20238,140 words Report 1460LGlioblastoma (GBM) is the most aggressive tumor in the central nervous system and contains a highly immunosuppressive tumor microenvironment (TME). Tumor-associated macrophages and microglia (TAMs) are a dominant...

• Age-related differences in striatal dopamine D1 receptors mediate subjective drug effects.

  Authors:Peter Manza, Ehsan Shokri-Kojori, Sukru Baris Demiral, Rui Zhang, Evan Dennis, Allison Johnson, et al.From:Journal of Clinical Investigation (Vol. 133, Issue 1) Peer-Reviewed

  Jan. 20231,239 words Letter to the editor... 1280LTo the Editor: The brain's dopamine system is critical for cognition, reward, and motivation. It plays a crucial role in the reinforcing effects of drugs with addiction potential as well as in some of their therapeutic...

• Notch1 signaling impairs regulatory T cells during multisystem inflammatory syndrome in children.

  Authors:Magali Noval Rivas and Moshe ArditiFrom:Journal of Clinical Investigation (Vol. 133, Issue 1) Peer-Reviewed

  Jan. 20232,223 words Article 1470LMultisystem inflammatory syndrome in children (MIS-C) is a rare pediatric inflammatory disorder characterized by immune cell hyperactivation, cytokine storm, and the production of autoantibodies. The mechanisms...

• Mitochondrial dysfunction reactivates a-fetoprotein expression that drives copper-dependent immunosuppression in mitochondrial disease models.

  Authors:Kimberly A. Jett, Zakery N. Baker, Amzad Hossain, Aren Boulet, Paul A. Cobine, Sagnika Ghosh, et al.From:Journal of Clinical Investigation (Vol. 133, Issue 1) Peer-Reviewed

  Jan. 202310,071 words Report 1450LSignaling circuits crucial to systemic physiology are widespread, yet uncovering their molecular underpinnings remains a barrier to understanding the etiology of many metabolic disorders. Here, we identified a...

• Type I regulatory T cells in malaria: of mice and men.

  Authors:Jason Nideffer and Prasanna JagannathanFrom:Journal of Clinical Investigation (Vol. 133, Issue 1) Peer-Reviewed

  Jan. 20232,352 words Article 1460LType I regulatory T (Tr1) cells are a population of regulatory [CD4.sup.+] T cells implicated in the suppression of pathological immune responses across multiple diseases, but a unifying transcriptional signature of Tr1...

• Canagliflozin primes antitumor immunity by triggering PD-L1 degradation in endocytic recycling.

  Authors:Ling Ding, Xi Chen, Wenxin Zhang, Xiaoyang Dai, Hongjie Guo, Xiaohui Pan, et al.From:Journal of Clinical Investigation (Vol. 133, Issue 1) Peer-Reviewed

  Jan. 202311,202 words Report 1350LUnderstanding the regulatory mechanisms of PD-L1 expression in tumors provides key clues for improving immune checkpoint blockade efficacy or developing novel oncoimmunotherapy. Here, we showed that the FDA-approved...

• Identification of a neutrophil-specific PIK3R1 mutation facilitates targeted treatment in a patient with Sweet syndrome.

  Authors:Shreya Bhattacharya, Sayon Basu, Emily Sheng, Christina Murphy, Jenny Wei, Anna E. Kersh, et al.From:Journal of Clinical Investigation (Vol. 133, Issue 1) Peer-Reviewed

  Jan. 20235,627 words Clinical report 1330LBACKGROUND. Acute febrile neutrophilic dermatosis (Sweet syndrome) is a potentially fatal multiorgan inflammatory disease characterized by fever, leukocytosis, and a rash with a neutrophilic infiltrate. The disease...

• Integration of ER protein quality control mechanisms defines [beta] cell function and ER architecture.

  Authors:Neha Shrestha, Mauricio Torres, Jason Zhang, You Lu, Leena Haataja, Rachel B. Reinert, et al.From:Journal of Clinical Investigation (Vol. 133, Issue 1) Peer-Reviewed

  Jan. 20236,686 words Report 1470LThree principal ER quality-control mechanisms, namely, the unfolded protein response, ER-associated degradation (ERAD), and ER-phagy are each important for the maintenance of ER homeostasis, yet how they are integrated...

• Molecular identification of bulbospinal ON neurons by GPER, which drives pain and morphine tolerance.

  Authors:Yingfu Jiao, Po Gao, Li Dong, Xiaowei Ding, Youqiang Meng, Jiahong Qian, et al.From:Journal of Clinical Investigation (Vol. 133, Issue 1) Peer-Reviewed

  Jan. 202311,788 words Report 1420LThe rostral ventromedial medulla (RVM) exerts bidirectional descending modulation of pain attributable to the activity of electrophysiologically identified pronociceptive ON and antinociceptive OFF neurons. Here, we...

• Targeting fatty acid metabolism in glioblastoma.

  Authors:Jason Miska and Navdeep S. ChandelFrom:Journal of Clinical Investigation (Vol. 133, Issue 1) Peer-Reviewed

  Jan. 20239,099 words Report 1380LGlioblastoma (GBM) is a primary tumor of the brain defined by its uniform lethality and resistance to conventional therapies. There have been considerable efforts to untangle the metabolic underpinnings of this disease...

• Human IL-10-producing Th1 cells exhibit a molecular signature distinct from Tr1 cells in malaria.

  Authors:Chelsea L. Edwards, Susanna S. Ng, Fabian de Labastida Rivera, Dillon Corvino, Jessica A. Engel, Marcela Montes de Oca, et al.From:Journal of Clinical Investigation (Vol. 133, Issue 1) Peer-Reviewed

  Jan. 202310,446 words Report 1480LControl of intracellular parasites responsible for malaria requires host IFN-[[gamma].sup.+]T-[bet.sup.+][CD4.sup.+] T cells (Th1 cells) with IL-10 produced by Th1 cells to mitigate the pathology induced by this...

• The Notch1/CD22 signaling axis disrupts Treg function in SARS-CoV-2-associated multisystem inflammatory syndrome in children.

  Authors:Mehdi Benamar, Qian Chen, Janet Chou, Amelie M. Jule, Rafik Boudra, Paola Contini, et al.From:Journal of Clinical Investigation (Vol. 133, Issue 1) Peer-Reviewed

  Jan. 202311,676 words Report 1480LMultisystem inflammatory syndrome in children (MIS-C) evolves in some pediatric patients following acute infection with SARS-CoV-2 by hitherto unknown mechanisms. Whereas acute-COVID-19 severity and outcomes were...

• Cargo selection in endoplasmic reticulum-to-Golgi transport and relevant diseases.

  Authors:Vi. T. Tang and David GinsburgFrom:Journal of Clinical Investigation (Vol. 133, Issue 1) Peer-Reviewed

  Jan. 20239,520 words Report 1410LMost proteins destined for the extracellular space or various intracellular compartments must traverse the intracellular secretory pathway. The first step is the recruitment and transport of cargoes from the endoplasmic...

• Liver-resident [CD8.sup.+] T cells in viral hepatitis: not always good guys.

  Authors:Hendrik Luxenburger and Christoph Neumann-HaefelinFrom:Journal of Clinical Investigation (Vol. 133, Issue 1) Peer-Reviewed

  Jan. 20232,333 words Article 1580LMore than twenty years ago, non-HBV-specific [CD8.sup.+] T cells were found to contribute to liver immunopathology in chronic HBV infection, while HBV-specific [CD8.sup.+] T cells were noted to contribute to viral...

• Longitudinal liver sampling in patients with chronic hepatitis B starting antiviral therapy reveals hepatotoxic [CD8.sup.+] T cells.

  Authors:Shirin Nkongolo, Deeqa Mahamed, Adrian Kuipery, Juan D. Sanchez Vasquez, Samuel C. Kim, Aman Mehrotra, et al.From:Journal of Clinical Investigation (Vol. 133, Issue 1) Peer-Reviewed

  Jan. 202311,095 words Report 1360LAccumulation of activated immune cells results in nonspecific hepatocyte killing in chronic hepatitis B (CHB), leading to fibrosis and cirrhosis. This study aims to understand the underlying mechanisms in humans and to...

• Monocyte-neutrophil entanglement in glioblastoma.

  Authors:Dinorah Friedmann-Morvinski and Dolores HambardzumyanFrom:Journal of Clinical Investigation (Vol. 133, Issue 1) Peer-Reviewed

  Jan. 20239,186 words Report 1440LGlioblastoma (GBM) is the most belligerent and frequent brain tumor in adults. Research over the past two decades has provided increased knowledge of the genomic and molecular landscape of GBM and highlighted the...