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    Academic Journals

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• A phosphorylation switch controls androgen biosynthesis in prostate cancer.

  Author:Yun QiuFrom:Journal of Clinical Investigation (Vol. 133, Issue 2) Peer-Reviewed

  Jan. 15, 20231,512 words Article 1360LAndrogen biosynthesis enzyme 3[beta]-hydroxysteroid dehydrogenase type 1(3[beta]HSD1) encoded by HSD3B1 has emerged as a potential driver for therapeutic resistance in prostate cancer. Patients with homozygous...

• Trained immunity is induced in humans after immunization with an adenoviral vector COVID-19 vaccine.

  Authors:Dearbhla M. Murphy, Donal J. Cox, Sarah A. Connolly, Eamon P. Breen, Aenea A.I. Brugman, James J. Phelan, et al.From:Journal of Clinical Investigation (Vol. 133, Issue 2) Peer-Reviewed

  Jan. 15, 20239,600 words Report 1480LBACKGROUND. Heterologous effects of vaccines are mediated by "trained immunity," whereby myeloid cells are metabolically and epigenetically reprogrammed, resulting in heightened responses to subsequent insults....

• Impact of epigenetic reprogramming on antitumor immune responses in glioma.

  Authors:Brandon L. McClellan, Santiago Haase, Felipe J. Nunez, Mahmoud S. Alghamri, Ali A. Dabaja, Pedro R. Lowenstein, et al.From:Journal of Clinical Investigation (Vol. 133, Issue 2) Peer-Reviewed

  Jan. 15, 20238,683 words Report 1340LEpigenetic remodeling is a molecular hallmark of gliomas, and it has been identified as a key mediator of glioma progression. Epigenetic dysregulation contributes to gliomagenesis, tumor progression, and responses to...

• Corrigendum.

  Authors:Pederico Perdomo-Celis, Caroline Passaes, Valerie Monceaux, Stevenn Volant, Faroudy Boufassa, Pierre de Truchis, et al.From:Journal of Clinical Investigation (Vol. 133, Issue 2) Peer-Reviewed

  Jan. 15, 202360 words Correction notice, B... 730LOriginal citation: J Clin Invest. 2022;132(11):e157549. https://doi.org/10.1172/JCI157549. Citation for this corrigendum: J Clin Invest. 2023;133(2):e167843. https://doi.org/10.1172/JCI167843. In Figure 1E, the data...

• Parvalbumin interneuron loss mediates repeated anesthesia-induced memory deficits in mice.

  Authors:Patricia Soriano Roque, Carolina Thorn Perez, Mehdi Hooshmandi, Calvin Wong, Mohammad Javad Eslamizade, Shilan Heshmati, et al.From:Journal of Clinical Investigation (Vol. 133, Issue 2) Peer-Reviewed

  Jan. 15, 20238,233 words Report 1390LRepeated or prolonged, but not short-term, general anesthesia during the early postnatal period causes long- lasting impairments in memory formation in various species. The mechanisms underlying long-lasting impairment...

• Take your mother's ferry: preimplantation embryo development requires maternal karyopherins for nuclear transport.

  Authors:Momal Sharif, Laura Detti, and Ignatia B. Van den VeyverFrom:Journal of Clinical Investigation (Vol. 133, Issue 2) Peer-Reviewed

  Jan. 15, 20231,837 words Article 1510LThe genetic basis of preimplantation embryo arrest is slowly being unraveled. Recent discoveries point to maternally expressed proteins required for cellular functions before the embryonic genome is activated. In this...

• Entry receptors--the gateway to alphavirus infection.

  Authors:Ofer Zimmerman, Autumn C. Holmes, Natasha M. Kafai, Lucas J. Adams, and Michael S. DiamondFrom:Journal of Clinical Investigation (Vol. 133, Issue 2) Peer-Reviewed

  Jan. 15, 202310,309 words Article 1310LAlphaviruses are enveloped, insect-transmitted, positive-sense RNA viruses that infect humans and other animals and cause a range of clinical manifestations, including arthritis, musculoskeletal disease, meningitis,...

• Features of tumor-microenvironment images predict targeted therapy survival benefit in patients with EGFR-mutant lung cancer.

  Authors:Shidan Wang, Ruichen Rong, Donghan M. Yang, Junya Fujimoto, Justin A. Bishop, Shirley Yan, et al.From:Journal of Clinical Investigation (Vol. 133, Issue 2) Peer-Reviewed

  Jan. 15, 20236,612 words Report 1510LTyrosine kinase inhibitors (TKIs) targeting epidermal growth factor receptor (EGFR) are effective for many patients with lung cancer with EGFR mutations. However, not all patients are responsive to EGFR TKIs, including...

• Superenhancer activation of KLHDC8A drives glioma ciliation and hedgehog signaling.

  Authors:Derrick Lee, Ryan C. Gimple, Xujia Wu, Briana C. Prager, Zhixin Qiu, Qiulian Wu, et al.From:Journal of Clinical Investigation (Vol. 133, Issue 2) Peer-Reviewed

  Jan. 15, 202310,983 words Report 1410LGlioblastoma ranks among the most aggressive and lethal of all human cancers. Self-renewing, highly tumorigenic glioblastoma stem cells (GSCs) contribute to therapeutic resistance and maintain cellular heterogeneity....

• The kynurenine pathway implicated in patient delirium: possible indications for indoleamine 2,3 dioxygenase inhibitors.

  Authors:Amy B. Heimberger and Rimas V. LukasFrom:Journal of Clinical Investigation (Vol. 133, Issue 2) Peer-Reviewed

  Jan. 15, 20232,227 words Article 1500LTryptophan (Trp) metabolism plays a central role in sleep, mood, and immune system regulation. The kynurenine pathway (KP), which is regulated by the enzymes tryptophan 2,3-dioxygenase (TDO) and indoleamine 2,3...

• Aflibercept more effectively weans patients with neovascular age-related macular degeneration off therapy compared with bevacizumab.

  Authors:Xuan Cao, Jaron Castillo Sanchez, Tapan P. Patel, Zhiyong Yang, Chuanyu Guo, Danyal Malik, et al.From:Journal of Clinical Investigation (Vol. 133, Issue 2) Peer-Reviewed

  Jan. 15, 20238,447 words Report 1500LBACKGROUND. Studies assessing the efficacy of therapies for neovascular age-related macular degeneration (nvAMD) have demonstrated that aflibercept may have a longer treatment interval than its less-expensive...

• Vaxxing to elimination: smallpox vaccines as tools to fight mpox.

  Authors:Boghuma K. Titanji and Vincent C. MarconiFrom:Journal of Clinical Investigation (Vol. 133, Issue 2) Peer-Reviewed

  Jan. 15, 20233,146 words Viewpoint essay 1440LIntroduction An outbreak of monkeypox (mpox) virus emerged on the global landscape in May 2022 and rapidly spread to several nonendemic countries in every WHO health region. To date, over 80,000 cases have been...

• Immune checkpoint blockade in glioblastoma: from tumor heterogeneity to personalized treatment.

  Authors:Victor A. Arrieta, Crismita Dmello, Daniel J. McGrail, Daniel J. Brat, Catalina Lee-Chang, Amy B. Heimberger, et al.From:Journal of Clinical Investigation (Vol. 133, Issue 2) Peer-Reviewed

  Jan. 15, 20238,077 words Report 1600LImmune checkpoint blockade (ICB) has revolutionized modern cancer therapy, arousing great interest in the neuro- oncology community. While several reports show that subsets of patients with glioma exhibit durable...

• mTOR regulates T cell exhaustion and PD-1-targeted immunotherapy response during chronic viral infection.

  Authors:Satomi Ando, Charles M. Perkins, Yamato Sajiki, Chase Chastain, Rajesh M. Valanparambil, Andreas Wieland, et al.From:Journal of Clinical Investigation (Vol. 133, Issue 2) Peer-Reviewed

  Jan. 15, 202310,410 words Report 1510LT cell exhaustion is a state of T cell dysfunction associated with expression of programmed death 1 (PD-1). Exhausted [CD8.sup.+] T cells are maintained by self-renewing stem-like T cells that provide differentiated...

• Corrigendum.

  Authors:Nan Chiang, Stephania Libreros, Paul C. Norris, Xavier de la Rosa, and Charles N. SerhanFrom:Journal of Clinical Investigation (Vol. 133, Issue 2) Peer-Reviewed

  Jan. 15, 202374 words Correction notice, B... 920LOriginal citation: J Clin Invest. 2019;129(12):5294-5311. https://doi.org/10.1172/JCI129448. Citation for this corrigendum: J Clin Invest. 2023;133(2):e168084. https://doi.org/10.1172/JCI168084. The authors recently...

• BMX controls 3[beta]HSD1 and sex steroid biosynthesis in cancer.

  Authors:Xiuxiu Li, Michael Berk, Christopher Goins, Mohammad Alyamani, Yoon-Mi Chung, Chenyao Wang, et al.From:Journal of Clinical Investigation (Vol. 133, Issue 2) Peer-Reviewed

  Jan. 15, 202310,106 words Report 1380LProstate cancer is highly dependent on androgens and the androgen receptor (AR). Hormonal therapies inhibit gonadal testosterone production, block extragonadal androgen biosynthesis, or directly antagonize AR. Resistance...

• Corrigendum.

  Authors:Krishnaraj S. Rathod, Vikas Kapil, Shanti Velmurugan, Rayomand S. Khambata, Umme Siddique, Saima Khan, et al.From:Journal of Clinical Investigation (Vol. 133, Issue 2) Peer-Reviewed

  Jan. 15, 2023214 words Correction notice, B... 1020LOriginal citation: J Clin Invest. 2017;127(1):169-182. https://doi.org/10.1172/JCI89429. Citation for this corrigendum: J Clin Invest. 2023;133(2):e168068. https://doi.org/10.1172/JCI168068. The authors recently...

• Cerebrospinal fluid quinolinic acid is strongly associated with delirium and mortality in hip-fracture patients.

  Authors:Leiv Otto Watne, Christian Thomas Pollmann, Bjorn Erik Neerland, Else Quist-Paulsen, Nathalie Bodd Halaas, Ane-Victoria Idland, et al.From:Journal of Clinical Investigation (Vol. 133, Issue 2) Peer-Reviewed

  Jan. 15, 20237,018 words Report 1420LBACKGROUND. The kynurenine pathway (KP) has been identified as a potential mediator linking acute illness to cognitive dysfunction by generating neuroactive metabolites in response to inflammation. Delirium (acute...

• Karyopherin [alpha] deficiency contributes to human preimplantation embryo arrest.

  Authors:Wenjing Wang, Yoichi Miyamoto, Biaobang Chen, Juanzi Shi, Feiyang Diao, Wei Zheng, et al.From:Journal of Clinical Investigation (Vol. 133, Issue 2) Peer-Reviewed

  Jan. 15, 20239,678 words Report 1390LPreimplantation embryo arrest (PREMBA) is a common cause of female infertility and recurrent failure of assisted reproductive technology. However, the genetic basis of PREMBA is largely unrevealed. Here, using...

• Lessons learned: from mentored to mentor.

  Author:Joseph HeitmanFrom:Journal of Clinical Investigation (Vol. 133, Issue 2) Peer-Reviewed

  Jan. 15, 20232,587 words Viewpoint essay 1360LThis Viewpoint was written in association with the 25th anniversary of the American Society for Clinical Investigation's (ASCI's) Stanley J. Korsmeyer Award, which honors the highest standards of scientific excellence,...