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    Academic Journals

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• Striving toward hyperthermia-free analgesia: lessons from loss-of-function mutations of human TRPV1.

  Authors:Tingting Li and Man-Kyo ChungFrom:Journal of Clinical Investigation (Vol. 133, Issue 3) Peer-Reviewed

  Feb. 1, 20232,311 words Article 1410LTransient receptor potential vanilloid 1 (TRPV1), a receptor for capsaicin and noxious heat, has been one of the most compelling targets for analgesics. However, systemic inhibition of TRPV1 is an impractical approach as...

• Mini-dCas13X-mediated RNA editing restores dystrophin expression in a humanized mouse model of Duchenne muscular dystrophy.

  Authors:Guoling Li, Ming Jin, Zhifang Li, Qingquan Xiao, Jiajia Lin, Dong Yang, et al.From:Journal of Clinical Investigation (Vol. 133, Issue 3) Peer-Reviewed

  Feb. 1, 20238,899 words Report 1570LApproximately 10% of monogenic diseases are caused by nonsense point mutations that generate premature termination codons (PTCs), resulting in a truncated protein and nonsense-mediated decay of the mutant mRNAs. Here, we...

• Avoid being trapped by your liver: ischemia-reperfusion injury in liver transplant triggers SIP-mediated NETosis.

  Authors:Davide Scozzi and Andrew E. GelmanFrom:Journal of Clinical Investigation (Vol. 133, Issue 3) Peer-Reviewed

  Feb. 1, 20232,113 words Article 1420LLiver transplantation can be a life-saving treatment for end-stage hepatic disease. Unfortunately, some recipients develop ischemia-reperfusion injury (IRI) that leads to poor short- and long-term outcomes. Recent work...

• NLRP12 is an innate immune checkpoint for repressing IFN signatures and attenuating lupus nephritis progression.

  Authors:Yen-Po Tsao, Fang-Yu Tseng, Chih-Wei Chao, Ming-Han Chen, Yi-Chen Yeh, Babamale Olarewaju Abdulkareem, et al.From:Journal of Clinical Investigation (Vol. 133, Issue 3) Peer-Reviewed

  Feb. 1, 202311,753 words Report 1490LSignaling driven by nucleic acid sensors participates in interferonopathy-mediated autoimmune diseases. NLRP12, a pyrin-containing NLR protein, is a negative regulator of innate immune activation and type I interferon...

• Recombinant vesicular stomatitis virus-vectored vaccine induces long-lasting immunity against Nipah virus disease.

  Authors:Courtney Woolsey, Viktoriya Borisevich, Alyssa C. Fears, Krystle N. Agans, Daniel J. Deer, Abhishek N. Prasad, et al.From:Journal of Clinical Investigation (Vol. 133, Issue 3) Peer-Reviewed

  Feb. 1, 20239,908 words Report 1390LThe emergence of the novel henipavirus, Langya virus, received global attention after the virus sickened over three dozen people in China. There is heightened concern that henipaviruses, as respiratory pathogens, could...

• Long noncoding RNA LEENE promotes angiogenesis and ischemic recovery in diabetes models.

  Authors:Xiaofang Tang, Yingjun Luo, Dongqiang Yuan, Riccardo Calandrelli, Naseeb Kaur Malhi, Kiran Sriram, et al.From:Journal of Clinical Investigation (Vol. 133, Issue 3) Peer-Reviewed

  Feb. 1, 20239,925 words Report 1420LImpaired angiogenesis in diabetes is a key process contributing to ischemic diseases such as peripheral arterial disease. Epigenetic mechanisms, including those mediated by long noncoding RNAs (lncRNAs), are crucial...

• Cotargeting of BTK and MALT overcomes resistance to BTK inhibitors in mantle cell lymphoma.

  Authors:Vivian Changying Jiang, Yang Liu, Junwei Lian, Shengjian Huang, Alexa Jordan, Qingsong Cai, et al.From:Journal of Clinical Investigation (Vol. 133, Issue 3) Peer-Reviewed

  Feb. 1, 20239,795 words Report 1390LBruton's tyrosine kinase (BTK) is a proven target in mantle cell lymphoma (MCL), an aggressive subtype of non-Hodgkin lymphoma. However, resistance to BTK inhibitors is a major clinical challenge. We here report that...

• Corrigendum.

  Authors:Ming Qi, Shuran Fan, Maohua Huang, Jinghua Pan, Yong Li, Qun Miao, et al.From:Journal of Clinical Investigation (Vol. 133, Issue 3) Peer-Reviewed

  Feb. 1, 202340 words Correction notice, B... 720LOriginal citation: J Clin Invest. 2022;132(19):1-18. https://doi.org/10.n72/JCI157399. https://doi.org/10.1172/JCI168771 After the publication of this article, the authors became aware that the [beta]-actin blot...

• IFN-[gamma]R/STAT1 signaling in recipient hematopoietic antigen-presenting cells suppresses graft-versus-host disease.

  Authors:Caisheng Lu, Huihui Ma, Liangsong Song, Hui Wang, Lily Wang, Shirong Li, et al.From:Journal of Clinical Investigation (Vol. 133, Issue 3) Peer-Reviewed

  Feb. 1, 202310,922 words Report 1510LThe absence of IFN-[gamma] receptor (IFN-[gamma]R) or STAT1 signaling in donor cells has been shown to result in reduced induction of acute graft-versus-host disease (GVHD). In this study, we unexpectedly observed...

• Chronic viral coinfections differentially affect the likelihood of developing long COVID.

  Authors:Michael J. Peluso, Tyler-Marie Deveau, Sadie E. Munter, Dylan Ryder, Amanda Buck, Gabriele Beck-Engeser, et al.From:Journal of Clinical Investigation (Vol. 133, Issue 3) Peer-Reviewed

  Feb. 1, 20237,888 words Report 1560LBACKGROUND. The presence and reactivation of chronic viral infections, such as EBV, CMV, and HIV, have been proposed as potential contributors to long COVID (LC), but studies in well-characterized postacute cohorts of...

• Dual gut hormone receptor agonists for diabetes and obesity.

  Authors:Joseph Bass, Matthias H. Tschop, and Lisa R. BeutlerFrom:Journal of Clinical Investigation (Vol. 133, Issue 3) Peer-Reviewed

  Feb. 1, 20232,457 words Viewpoint essay 1400LIntroduction The epidemics of obesity and type 2 diabetes mellitus (T2DM) pose enormous threats to human health. Weight loss of at least 5%-10% attenuates the severity of these disorders and their complications. Diet...

• Neutrophil CEACAM1 determines susceptibility to NETosis by regulating the S1PR2/S1PR3 axis in liver transplantation.

  Authors:Hirofumi Hirao, Hidenobu Kojima, Kenneth J. Dery, Kojiro Nakamura, Kentaro Kadono, Yuan Zhai, et al.From:Journal of Clinical Investigation (Vol. 133, Issue 3) Peer-Reviewed

  Feb. 1, 202310,766 words Report 1400LNeutrophils, the largest innate immune cell population in humans, are the primary proinflammatory sentinel in the ischemia-reperfusion injury (IRI) mechanism in orthotopic liver transplantation (OLT). Carcinoembryonic...

• Nociception and pain in humans lacking a functional TRPV1 channel.

  Authors:Ben Katz, Rachel Zaguri, Simon Edvardson, Channa Maayan, Orly Elpeleg, Shaya Lev, et al.From:Journal of Clinical Investigation (Vol. 133, Issue 3) Peer-Reviewed

  Feb. 1, 202311,906 words Report 1470LBACKGROUND. Chronic pain is a debilitating illness with currently limited therapy, in part due to difficulties in translating treatments derived from animal models to patients. The transient receptor potential vanilloid...

• A human TRPV1 genetic variant within the channel gating domain regulates pain sensitivity in rodents.

  Authors:Shufang He, Vanessa O. Zambelli, Pritam Sinharoy, Laura Brabenec, Yang Bian, Freeborn Rwere, et al.From:Journal of Clinical Investigation (Vol. 133, Issue 3) Peer-Reviewed

  Feb. 1, 202311,589 words Report 1410LPain signals are relayed to the brain via a nociceptive system, and in rare cases, this nociceptive system contains genetic variants that can limit the pain response. Here, we questioned whether a human transient...

• Thioredoxin 1 promotes autophagy through transnitrosylation of Atg7 during myocardial ischemia.

  Authors:Narayani Nagarajan, Shin-ichi Oka, Jihoon Nah, Changgong Wu, Peiyong Zhai, Risa Mukai, et al.From:Journal of Clinical Investigation (Vol. 133, Issue 3) Peer-Reviewed

  Feb. 1, 202311,225 words Report 1290LModification of cysteine residues by oxidative and nitrosative stress affects structure and function of proteins, thereby contributing to the pathogenesis of cardiovascular disease. Although the major function of...

• Unwind to the beat: chromatin and cardiac conduction.

  Authors:Douglas J. Chapski and Thomas M. VondriskaFrom:Journal of Clinical Investigation (Vol. 133, Issue 3) Peer-Reviewed

  Feb. 1, 20232,470 words Article 1570LHow chromatin accessibility and structure endow highly specialized cells with their unique phenotypes is an area of intense investigation. In the mammalian heart, an exclusive subset of cardiac cells comprise the...

• PD-L1 translocation to the plasma membrane enables tumor immune evasion through MIB2 ubiquitination.

  Authors:Xinfang Yu, Wei Li, Haidan Liu, Xu Wang, Cristian Coarfa, Chao Cheng, et al.From:Journal of Clinical Investigation (Vol. 133, Issue 3) Peer-Reviewed

  Feb. 1, 20238,917 words Report 1390LProgrammed death-ligand 1 (PD-L1), a critical immune checkpoint ligand, is a transmembrane protein synthesized in the endoplasmic reticulum of tumor cells and transported to the plasma membrane to interact with...

• Unlocking life-threatening COVID-19 through two types of inborn errors of type I IFNs.

  Authors:Jean-Laurent Casanova and Mark S. AndersonFrom:Journal of Clinical Investigation (Vol. 133, Issue 3) Peer-Reviewed

  Feb. 1, 202310,327 words Report 1350LSince 2003, rare inborn errors of human type I IFN immunity have been discovered, each underlying a few severe viral illnesses. Autoantibodies neutralizing type I IFNs due to rare inborn errors of autoimmune regulator...

• A non-neutralizing glycoprotein B monoclonal antibody protects against herpes simplex virus disease in mice.

  Authors:Masayuki Kuraoka, Clare Burn Aschner, Ian W. Windsor, Aakash Mahant Mahant, Scott J. Garforth, Susan Luozheng Kong, et al.From:Journal of Clinical Investigation (Vol. 133, Issue 3) Peer-Reviewed

  Feb. 1, 202310,218 words Report 1470LThere is an unmet need for monoclonal antibodies (mAbs) for prevention or as adjunctive treatment of herpes simplex virus (HSV) disease. Most vaccine and mAb efforts focus on neutralizing antibodies, but for HSV this...

• SLC26A1 is a major determinant of sulfate homeostasis in humans.

  Authors:Anja Pfau, Karen I. Lopez-Cayuqueo, Nora Scherer, Matthias Wuttke, Annekatrin Wernstedt, Daniela Gonzalez Fassrainer, et al.From:Journal of Clinical Investigation (Vol. 133, Issue 3) Peer-Reviewed

  Feb. 1, 20237,870 words Report 1450LSulfate plays a pivotal role in numerous physiological processes in the human body, including bone and cartilage health. A role of the anion transporter SLC26A1 (Sat1) for sulfate reabsorption in the kidney is supported...