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    Academic Journals

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• Guanylyl cyclase C ameliorates visceral pain: an unsuspected link.

  Author:Rodger A. LiddleFrom:Journal of Clinical Investigation (Vol. 133, Issue 4) Peer-Reviewed

  Feb. 15, 20231,963 words Article 1340LVisceral pain associated with irritable bowel syndrome afflicts 15% of the US population. Although treatments are limited, guanylyl cyclase C (GUCY2C) agonists alleviate pain and constipation. Until now, it was assumed...

• A systems biology approach identifies the role of dysregulated PRDM6 in the development of hypertension.

  Authors:Kushan L. Gunawardhana, Lingjuan Hong, Trojan Rugira, Severin Uebbing, Joanna Kucharczak, Sameet Mehta, et al.From:Journal of Clinical Investigation (Vol. 133, Issue 4) Peer-Reviewed

  Feb. 15, 20238,963 words Report 1380LGenetic variants in the third intron of the PRDM6 gene have been associated with BP traits in multiple GWAS. By combining fine mapping, massively parallel reporter assays, and gene editing, we identified super enhancers...

• Reduced methylation correlates with diabetic nephropathy risk in type 1 diabetes.

  Authors:Ishant Khurana, Harikrishnan Kaipananickal, Scott Maxwell, Serine Birkelund, and Anna SyreeniFrom:Journal of Clinical Investigation (Vol. 133, Issue 4) Peer-Reviewed

  Feb. 15, 202310,116 words Report 1370LDiabetic nephropathy (DN) is a polygenic disorder with few risk variants showing robust replication in large-scale genome-wide association studies. To understand the role of DNA methylation, it is important to have the...

• Corrigendum: Aberrant miR-339-5p/neuronatin signaling causes prodromal neuronal calcium dyshomeostasis in mutant presenilin mice.

  From:Journal of Clinical Investigation (Vol. 133, Issue 4) Peer-Reviewed

  Feb. 15, 202393 words Correction notice, B... 1100LHao-Yu Zou, Lin Guo, Bei Zhang, Si Chen, Xin-Rong Wu, Xian-Dong Liu, Xin-Yu Xu, Bin-Yin Li, Shengdi Chen, Nan-Jie Xu, and Suya Sun Original citation: J Clin Invest. 2022;132(8):e149160. https://doi.org/10.1172/JCI149160....

• SHP2 deneddylation mediates tumor immunosuppression in colon cancer via the CD47/SIRP[alpha] axis.

  Authors:Yiqing Li, Hui Zhou, Pan Liu, Dandan Lv, Yichun Shi, Bufu Tang, et al.From:Journal of Clinical Investigation (Vol. 133, Issue 4) Peer-Reviewed

  Feb. 15, 202310,764 words Report 1310LSIPR[alpha] on macrophages binds with CD47 to resist proengulfment signals, but how the downstream signal of SIPR[alpha] controls tumor-infiltrating macrophages (TIMs) is still poorly clarified. Here, we report that the...

• Waking immune-resistant tumors with neddylation.

  Authors:Kristin Huntoon, Wen Jiang, and Betty Y.S. KimFrom:Journal of Clinical Investigation (Vol. 133, Issue 4) Peer-Reviewed

  Feb. 15, 20231,906 words Article 1480LThe CD47/signal regulatory protein [alpha] (SIRP[alpha]) axis, which functions as an inhibitory phagocytosis checkpoint, also serves as a key mediator in cancer immune evasion. Many cancers, including colorectal cancer...

• Loss of LGR4/GPR48 causes severe neonatal salt wasting due to disrupted WNT signaling altering adrenal zonation.

  Authors:Cecily Lucas, Kay-Sara Sauter, Michael Steigert, Delphine Mallet, James Wilmouth, Julie Olabe, et al.From:Journal of Clinical Investigation (Vol. 133, Issue 4) Peer-Reviewed

  Feb. 15, 20235,759 words Report 1410LDisorders of isolated mineralocorticoid deficiency, which cause potentially life-threatening salt-wasting crisis early in life, have been associated with gene variants of aldosterone biosynthesis or resistance; however,...

• UBC9 deficiency enhances immunostimulatory macrophage activation and subsequent antitumor T cell response in prostate cancer.

  Authors:Jun Xiao, Fei Sun, Ya-Nan Wang, Bo Liu, Peng Zhou, Fa-Xi Wang, et al.From:Journal of Clinical Investigation (Vol. 133, Issue 4) Peer-Reviewed

  Feb. 15, 20239,583 words Report 1410LThe role of tumor-associated macrophages (TAMs), along with the regulatory mechanisms underlying distinct macrophage activation states, remains poorly understood in prostate cancer (PCa). Herein, we report that PCa...

• Corrigendum: RANKL inhibition improves muscle strength and insulin sensitivity and restores bone mass.

  Authors:Nicolas Bonnet, Lucie Bourgoin, Emmanuel Biver, Eleni Douni, and Serge FerrariFrom:Journal of Clinical Investigation (Vol. 133, Issue 4) Peer-Reviewed

  Feb. 15, 2023212 words Correction notice, B... 910LOriginal citation: J Clin Invest. 2019;129(8):3214-3223. https://doi.org/10.1172/JCI125915. https://doi.org/10.1172/JCI169317 The authors recently became aware that an incorrect image was shown in Figure 6F for the...

• Early-life peripheral infections reprogram retinal microglia and aggravate neovascular age-related macular degeneration in later life.

  Authors:Masayuki Hata, Maki Hata, Elisabeth M.M.A. Andriessen, Rachel Juneau, Frederique Pilon, Sergio Crespo-Garcia, et al.From:Journal of Clinical Investigation (Vol. 133, Issue 4) Peer-Reviewed

  Feb. 15, 20239,468 words Report 1450LPathological neovascularization in age-related macular degeneration (nvAMD) drives the principal cause of blindness in the elderly. While there is a robust genetic association between genes of innate immunity and AMD,...

• Molecular pathways that drive diabetic kidney disease.

  Authors:Samer Mohandes, Tomohito Doke, Hailong Hu, Dhanunjay Mukhi, Poonam Dhillon, and Katalin SusztakFrom:Journal of Clinical Investigation (Vol. 133, Issue 4) Peer-Reviewed

  Feb. 15, 20239,818 words Report 1240LKidney disease is a major driver of mortality among patients with diabetes and diabetic kidney disease (DKD) is responsible for close to half of all chronic kidney disease cases. DKD usually develops in a genetically...

• Type 2 diabetes candidate genes, including PAX5, cause impaired insulin secretion in human pancreatic islets.

  Authors:Karl Bacos, Alexander Perfilyev, Alexandros Karagiannopoulos, Elaine Cowan, Jones K. Ofori, Ludivine Bertonnier-Brouty, et al.From:Journal of Clinical Investigation (Vol. 133, Issue 4) Peer-Reviewed

  Feb. 15, 202311,404 words Report 1540LType 2 diabetes (T2D) is caused by insufficient insulin secretion from pancreatic [beta] cells. To identify candidate genes contributing to T2D pathophysiology, we studied human pancreatic islets from approximately 300...

• Corrigendum: NLRP3 tyrosine phosphorylation is controlled by protein tyrosine phosphatase PTPN22.

  Authors:Marianne R. Spalinger, Stephanie Kasper, Claudia Gottier, Silvia Lang, Kirstin Atrott, Stephan R. Vavricka, et al.From:Journal of Clinical Investigation (Vol. 133, Issue 4) Peer-Reviewed

  Feb. 15, 202356 words Correction notice, B... 790LOriginal citation: J Clin Invest. 2016;126(5):1783-1800. https://doi.org/10.1172/JCI83669. https://doi.org/10.1172/JCI169304 The authors recently became aware of errors in Figure 8, A and B. In Figure 8A, the...

• TIGIT inhibition and lenalidomide synergistically promote antimyeloma immune responses after stem cell transplantation in mice.

  Authors:Simone A. Minnie, Olivia G. Waltner, Kathleen S. Ensbey, Stuart D. Olver, Alika D. Collinge, David P. Sester, et al.From:Journal of Clinical Investigation (Vol. 133, Issue 4) Peer-Reviewed

  Feb. 15, 20238,386 words Report 1460LAutologous stem cell transplantation (ASCT) with subsequent lenalidomide maintenance is standard consolidation therapy for multiple myeloma, and a subset of patients achieve durable progression-free survival that is...

• Mandibulofacial dysostosis with alopecia results from [ET.sub.A]R gain-of- function mutations via allosteric effects on ligand binding.

  Authors:Yukiko Kurihara, Toru Ekimoto, Christopher T. Gordon, Yasunobu Uchijima, Ryo Sugiyama, Taro Kitazawa, et al.From:Journal of Clinical Investigation (Vol. 133, Issue 4) Peer-Reviewed

  Feb. 15, 20239,774 words Report 1460LMutations of G protein-coupled receptors (GPCRs) cause various human diseases, but the mechanistic details are limited. Here, we establish p.E303K in the gene encoding the endothelin receptor type A ([ET.sub.A]R/EDNRA)...

• The UBE2C/CDH1/DEPTOR axis is an oncogene and tumor suppressor cascade in lung cancer cells.

  Authors:Shizhen Zhang, Xiahong You, Yawen Zheng, Yanwen Shen, Xiufang Xiong, and Yi SunFrom:Journal of Clinical Investigation (Vol. 133, Issue 4) Peer-Reviewed

  Feb. 15, 20239,003 words Report 1510LUbiquitin-conjugating enzyme E2C (UBE2C) mediates ubiquitylation chain formation via the K11 linkage. While previous in vitro studies showed that UBE2C plays a growth-promoting role in cancer cell lines, the underlying...

• A conversation with Jeffrey Whitsett.

  Author:Ushma S. NeillFrom:Journal of Clinical Investigation (Vol. 133, Issue 4) Peer-Reviewed

  Feb. 15, 20232,239 words Interview 1010LNeonatologist and pulmonary biologist Jeffrey Whitsett (Figure 1) of the Cincinnati Children's Hospital provided understanding of pulmonary surfactant biochemistry and structural biology that underpins the widespread...

• Leucine-973 is a crucial residue differentiating insulin and IGF-1 receptor signaling.

  Authors:Hirofumi Nagao, Weikang Cai, Bruna B. Brandao, Nicolai J. Wewer Albrechtsen, Martin Steger, Arijeet K. Gattu, et al.From:Journal of Clinical Investigation (Vol. 133, Issue 4) Peer-Reviewed

  Feb. 15, 202311,674 words Report 1540LInsulin and IGF-1 receptors (IR and IGF1R) are highly homologous and share similar signaling systems, but each has a unique physiological role, with IR primarily regulating metabolic homeostasis and IGF1R regulating...

• Butyrate ameliorates quinolinic acid-induced cognitive decline in obesity models.

  Authors:Xing Ge, Mingxuan Zheng, Minmin Hu, Xiaoli Fang, Deqin Geng, Sha Liu, et al.From:Journal of Clinical Investigation (Vol. 133, Issue 4) Peer-Reviewed

  Feb. 15, 202310,421 words Report 1320LObesity is a risk factor for neurodegenerative disease associated with cognitive dysfunction, including Alzheimer's disease. Low-grade inflammation is common in obesity, but the mechanism between inflammation and...

• Daytime-restricted parenteral feeding is associated with earlier oral intake in children following stem cell transplant.

  Authors:YunZu Michele Wang, Cynthia B. Taggart, John F. Huber, Stella M. Davies, David F. Smith, John B. Hogenesch, et al.From:Journal of Clinical Investigation (Vol. 133, Issue 4) Peer-Reviewed

  Feb. 15, 20231,280 words Letter to the editor 1400LTo the editor: In inpatients unable to sustain themselves enterally, standard i.v. total parenteral nutrition (TPN) is often administered over a 20- to 24-hour feeding period. However, feeding time is a dominant...