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    Academic Journals

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• Chronic pain and premature mortality in men and women, using data from UK Biobank.

  Authors:Gary J. Macfarlane, Marcus Beasley, and Gareth T. JonesFrom:Journal of Clinical Investigation (Vol. 133, Issue 5) Peer-Reviewed

  Mar. 1, 20231,642 words Letter to the editor 1420LTo the Editor: Muralidharan et al. (1) demonstrated that 4 months after nerve injury, male (but not female) mice demonstrated telomere length reduction and p53-mediated cellular senescence in the spinal cord, which was...

• A seed sequence variant in miR-145-5p causes multisystem smooth muscle dysfunction syndrome.

  Authors:Christian Lacks Lino Cardenas, Lauren C. Briere, David A. Sweetser, Mark E. Lindsay, and Patricia L. MusolinoFrom:Journal of Clinical Investigation (Vol. 133, Issue 5) Peer-Reviewed

  Mar. 1, 20231,204 words Clinical report, Let... 1440LTo the Editor: Multisystemic smooth muscle dysfunction syndrome (MSMDS, OMIM #613834) is an ultrarare smooth muscle myopathy (1). Cases are monogenic from missense variation at arginine 179 of the ACTA2 gene (1, 2)....

• Single-cell RNA sequencing and spatial transcriptomics reveal cancer-associated fibroblasts in glioblastoma with protumoral effects.

  Authors:Saket Jain, Jonathan W. Rick, Rushikesh S. Joshi, Angad Beniwal, Jordan Spatz, Sabraj Gill, et al.From:Journal of Clinical Investigation (Vol. 133, Issue 5) Peer-Reviewed

  Mar. 1, 202312,544 words Report 1450LCancer-associated fibroblasts (CAFs) were presumed absent in glioblastoma given the lack of brain fibroblasts. Serial trypsinization of glioblastoma specimens yielded cells with CAF morphology and single-cell...

• Cryptic lncRNA-encoded ORFs: A hidden source of regulatory proteins.

  Authors:Anindya Dutta, Hui Li, and Roger AbounaderFrom:Journal of Clinical Investigation (Vol. 133, Issue 5) Peer-Reviewed

  Mar. 1, 20231,583 words Article 1380LA majority of the human genome is transcribed into noncoding RNAs, of which long noncoding RNAs (lncRNAs) form a large and heterogeneous fraction. While lncRNAs are mostly noncoding, recent evidence suggests that cryptic...

• CRISPR/Cas9 screen uncovers functional translation of cryptic lncRNA-encoded open reading frames in human cancer.

  Authors:Caishang Zheng, Yanjun Wei, Peng Zhang, Longyong Xu, Zhenzhen Zhang, Kangyu Lin, et al.From:Journal of Clinical Investigation (Vol. 133, Issue 5) Peer-Reviewed

  Mar. 1, 202311,435 words Report 1530LEmerging evidence suggests that cryptic translation within long noncoding RNAs (lncRNAs) may produce novel proteins with important developmental/physiological functions. However, the role of this cryptic translation in...

• Conversion of [CD73.sup.hi][FR4.sup.hi] anergic T cells to IFN-[gamma]- producing effector cells disrupts established immune tolerance.

  Authors:Anil Dangi, Irma Husain, Collin Z. Jordan, Shuangjin Yu, and Xunrong LuoFrom:Journal of Clinical Investigation (Vol. 133, Issue 5) Peer-Reviewed

  Mar. 1, 20231,285 words Letter to the editor... 1430LTo the editor: Anergic T ([T.sub.AN]) cells marked by [CD73.sup.hi][FR4.sup.hi] have been shown to differentiate to immunosuppressive populations, such as [FoxP3.sup.+] Tregs or IL-10-producing Tr1 cells (1, 2), and are...

• A TRPV4-dependent neuroimmune axis in the spinal cord promotes neuropathic pain. (RESEARCH ARTICLE).

  Authors:Xueming Hu, Lixia Du, Shenbin Liu, Zhou Lan, Kaikai Zang, Jing Feng, et al.From:Journal of Clinical Investigation (Vol. 133, Issue 5) Peer-Reviewed

  Mar. 1, 202311,002 words Report 1550LMicroglia, resident macrophages of the CNS, are essential to brain development, homeostasis, and disease. Microglial activation and proliferation are hallmarks of many CNS diseases, including neuropathic pain. However,...

• Corrigendum.

  Authors:Shiqin Xiong, Zhigang Hong, Long Shuang Huang, Yoshikazu Tsukasaki, Saroj Nepal, Anke Di, et al.From:Journal of Clinical Investigation (Vol. 133, Issue 5) Peer-Reviewed

  Mar. 1, 202367 words Correction notice, B... 1170LOriginal citation: J Clin Invest. 2020;130(7):3684-3698. https://doi.org/10.1172/JCI136908. In the original version of Figure 4D, the representative lung histology sections of control and LPS-exposed animals,...

• Distinct early cellular kinetics in participants protected against colonization upon Bordetella pertussis challenge.

  Authors:Annieck M. Diks, Hans de Graaf, Cristina Teodosio, Rick J. Groenland, Bas de Mooij, Muktar Ibrahim, et al.From:Journal of Clinical Investigation (Vol. 133, Issue 5) Peer-Reviewed

  Mar. 1, 202310,726 words Report 1430LBACKGROUND. To date, only limited data are available on the mechanisms of protection against colonization with Bordetella pertussis in humans. METHODS. In this study, the cellular responses to B. pertussis challenge...

• TP63 gain-of-function mutations cause premature ovarian insufficiency by inducing oocyte apoptosis.

  Authors:Chengzi Huang, Simin Zhao, Yajuan Yang, Ting Guo, Hanni Ke, Xin Mi, et al.From:Journal of Clinical Investigation (Vol. 133, Issue 5) Peer-Reviewed

  Mar. 1, 20239,319 words Report 1410LThe transcription factor p63 guards genome integrity in the female germline, and its mutations have been reported in patients with premature ovarian insufficiency (POI). However, the precise contribution of the TP63 gene...

• Highly synchronized cortical circuit dynamics mediate spontaneous pain in mice.

  Authors:Weihua Ding, Lukas Fischer, Qian Chen, Ziyi Li, Liuyue Yang, Zerong You, et al.From:Journal of Clinical Investigation (Vol. 133, Issue 5) Peer-Reviewed

  Mar. 1, 202311,739 words Report 1370LCortical neural dynamics mediate information processing for the cerebral cortex, which is implicated in fundamental biological processes such as vision and olfaction, in addition to neurological and psychiatric diseases....

• BosR and PlzA reciprocally regulate RpoS function to sustain Borrelia burgdorferi in ticks and mammals.

  Authors:Andre A. Grassmann, Rafal Tokarz, Caroline Golino, Melissa A. McLain, Ashley M. Groshong, Justin D. Radolf, et al.From:Journal of Clinical Investigation (Vol. 133, Issue 5) Peer-Reviewed

  Mar. 1, 202310,424 words Report 1410LThe RNA polymerase alternative o factor RpoS in Borrelia burgdorferi (Bb), the Lyme disease pathogen, is responsible for programmatic-positive and -negative gene regulation essential for the spirochete's dual-host...

• Discovering chronic pain treatments: better animal models might help us get there.

  Authors:Norman E. Taylor and Luiz FerrariFrom:Journal of Clinical Investigation (Vol. 133, Issue 5) Peer-Reviewed

  Mar. 1, 20232,404 words Article 1580LOnly three classes of pain medications have made It Into clinical use In the past 60 years despite intensive efforts and the need for nonaddictive pain treatments. One reason for the failure involves the use of animal...

• Antigen specificity and cross-reactivity drive functionally diverse anti-Aspergillus fumigatus T cell responses in cystic fibrosis.

  Authors:Carsten Schwarz, Patience Eschenhagen, Henrijette Schmid, Thordis Hohnstein, Claudia Grehn, Christina Iwert, et al.From:Journal of Clinical Investigation (Vol. 133, Issue 5) Peer-Reviewed

  Mar. 1, 202311,809 words Report 1430LBACKGROUND. The fungus Aspergillus fumigatus causes a variety of clinical phenotypes in patients with cystic fibrosis (pwCF). Th cells orchestrate immune responses against fungi, but the types of A. fumigatus-specific Th...

• Digging deep into cells to find mechanisms of kidney protection by SGLT2 inhibitors.

  Author:Katherine R. TuttleFrom:Journal of Clinical Investigation (Vol. 133, Issue 5) Peer-Reviewed

  Mar. 1, 20232,603 words Article 1480LThe sodium-glucose cotransporter-2 (SGLT2) is expressed on the luminal side of proximal tubule epithelial cells in the kidney. While pharmacological inhibition of SGLT2 provides kidney protection in diabetic kidney...

• YAP1 and WWTR1 expression inversely correlates with neuroendocrine markers in Merkel cell carcinoma.

  Authors:Thomas C. Fros, Ashley K. Gartin, Mofei Liu, Jingwei Cheng, Harita Dharaneeswaran, Derin B. Keskin, et al.From:Journal of Clinical Investigation (Vol. 133, Issue 5) Peer-Reviewed

  Mar. 1, 202311,196 words Report 1470LBACKGROUND. Merkel cell carcinoma (MCC) is an aggressive neuroendocrine (NE) skin cancer caused by severe UV-induced mutations or expression of Merkel cell polyomavirus (MCPyV) large and small T antigens (LT and ST)....

• SGLT2 inhibitors mitigate kidney tubular metabolic and mTORC1 perturbations in youth-onset type 2 diabetes.

  Authors:Jennifer A. Schaub, Fadhl M. AlAkwaa, Phillip J. McCown, Abhijit S. Naik, Viji Nair, Sean Eddy, et al.From:Journal of Clinical Investigation (Vol. 133, Issue 5) Peer-Reviewed

  Mar. 1, 20239,541 words Report 1480LThe molecular mechanisms of sodium-glucose cotransporter-2 (SGLT2) inhibitors (SGLT2i) remain incompletely understood. Single-cell RNA sequencing and morphometric data were collected from research kidney biopsies donated...