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    Academic Journals

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• The ubiquitin ligase TRIM21 regulates mutant p53 accumulation and gain of function in cancer.

  Authors:Juan Liu, Cen Zhang, Dandan Xu, Tianliang Zhang, Chun-Yuan Chang, Jianming Wang, et al.From:Journal of Clinical Investigation (Vol. 133, Issue 6) Peer-Reviewed

  Mar. 15, 20239,992 words Report 1460LThe tumor suppressor TP53 is the most frequently mutated gene in human cancers. Mutant p53 (mutp53) proteins often accumulate to very high levels in human cancers to promote cancer progression through the...

• Astroglial toxicity promotes synaptic degeneration in the thalamocortical circuit in frontotemporal dementia with GRN mutations.

  Authors:Elise Marsan, Dmitry Velmeshev, Arren Ramsey, Ravi K. Patel, Jiasheng Zhang, Mark Koontz, et al.From:Journal of Clinical Investigation (Vol. 133, Issue 6) Peer-Reviewed

  Mar. 15, 202311,964 words Report 1490LMutations in the human progranulin (GRN) gene are a leading cause of frontotemporal lobar degeneration (FTLD). While previous studies implicate aberrant microglial activation as a disease-driving factor in...

• Th2-skewed T cells correlate with B cell response to [alpha]-Gal and tick antigens in [alpha]-Gal syndrome.

  Authors:Danijela Apostolovic, Jeanette Grundstrom, Mensiena B. Gea Kiewiet, Marija Perusko, Carl Hamsten, Maria Starkhammar, et al.From:Journal of Clinical Investigation (Vol. 133, Issue 6) Peer-Reviewed

  Mar. 15, 20238,786 words Report 1440LTick bites have been shown to transmit a novel form of severe food allergy, the galactose-[alpha]-1,3-galactose ([alpha]-Gal) syndrome (AGS). Cellular responses to [alpha]-Gal in patients with AGS have, to date, not been...

• Connexin hemichannels as candidate targets for cardioprotective and anti-arrhythmic treatments.

  Authors:Luc Leybaert, Maarten A.J. De Smet, Alessio Lissoni, Rosalie Allewaert, H. Llewelyn Roderick, Geert Bultynck, et al.From:Journal of Clinical Investigation (Vol. 133, Issue 6) Peer-Reviewed

  Mar. 15, 20239,873 words Report 1410LConnexins are crucial cardiac proteins that form hemichannels and gap junctions. Gap junctions are responsible for the propagation of electrical and chemical signals between myocardial cells and cells of the specialized...

• PP2Ac/STRN4 negatively regulates STING-type I IFN signaling in tumor-associated macrophages.

  Authors:Winson S. Ho, Isha Mondal, Beisi Xu, Oishika Das, Raymond Sun, Pochin Chiou, et al.From:Journal of Clinical Investigation (Vol. 133, Issue 6) Peer-Reviewed

  Mar. 15, 202312,303 words Report 1390LStimulator of IFN genes type I (STING-Type I) IFN signaling in myeloid cells plays a critical role in effective antitumor immune responses, but STING agonists as monotherapy have shown limited efficacy in clinical...

• Retraction: UCP2-induced fatty acid synthase promotes NLRP3 inflammasome activation during sepsis.

  Authors:Jong-Seok Moon, Seonmin Lee, Mi-Ae Park, Ilias I. Siempos, Maria Haslip, Patty J. Lee, et al.From:Journal of Clinical Investigation (Vol. 133, Issue 6) Peer-Reviewed

  Mar. 15, 202389 words Brief article 1060LJong-Seok Moon, Seonmin Lee, Mi-Ae Park, Ilias I. Siempos, Maria Haslip, Patty J. Lee, Mijin Yun, Chun K. Kim, Judie Howrylak, Stefan W. Ryter, Kiichi Nakahira, and Augustine M.K. Choi Original citation: J Clin Invest....

• The immunometabolite itaconate stimulates OXGR1 to promote mucociliary clearance during the pulmonary innate immune response.

  Authors:Yi-Rong Zeng, Jun-Bin Song, Dezheng Wang, Zi-Xuan Huang, Cheng Zhang, Yi-Ping Sun, et al.From:Journal of Clinical Investigation (Vol. 133, Issue 6) Peer-Reviewed

  Mar. 15, 20237,620 words Report 1430LPathogens and inflammatory conditions rapidly induce the expression of immune-responsive gene 1 (IRG1) in cells of myeloid lineage. IRG1 encodes an aconitate decarboxylase (ACOD1) that produces the immunomodulatory...

• SARS-CoV-2 variants resistant to monoclonal antibodies in immunocompromised patients is a public health concern.

  Authors:Arturo Casadevall and Daniele FocosiFrom:Journal of Clinical Investigation (Vol. 133, Issue 6) Peer-Reviewed

  Mar. 15, 20231,910 words Guest commentary 1420LCOVID-19 in immunocompromised hosts has emerged as a difficult therapeutic management problem. Immunocompromised hosts mount weak responses to SARS-CoV-2 and manifest infection outcomes ranging from severe disease to...

• Monogenic disease analysis establishes that fetal insulin accounts for half of human fetal growth.

  Authors:Alice E. Hughes, Elisa De Franco, Rachel M. Freathy, Sarah E. Flanagan, and Andrew T. HattersleyFrom:Journal of Clinical Investigation (Vol. 133, Issue 6) Peer-Reviewed

  Mar. 15, 20231,470 words Letter to the editor 1410LTo the Editor: Extremes in birth weight are associated with adverse pregnancy outcomes and long-term risk of cardiometabolic disease. Fetal insulin has long been recognized as an important regulator of fetal growth, but...

• SLAMF7 regulates the inflammatory response in macrophages during polymicrobial sepsis.

  Authors:Yongjian Wu, Qiaohua Wang, Miao Li, Juanfeng Lao, Huishu Tang, Siqi Ming, et al.From:Journal of Clinical Investigation (Vol. 133, Issue 6) Peer-Reviewed

  Mar. 15, 202311,613 words Report 1420LUncontrolled inflammation occurred in sepsis results in multiple organ injuries and shock, which contributes to the death of patients with sepsis. However, the regulatory mechanisms that restrict excessive inflammation...

• Targeting pleckstrin-2/Akt signaling reduces proliferation in myeloproliferative neoplasm models.

  Authors:Xu Han, Yang Mei, Rama K. Mishra, Honghao Bi, Atul D. Jain, Gary E. Schiltz, et al.From:Journal of Clinical Investigation (Vol. 133, Issue 6) Peer-Reviewed

  Mar. 15, 202311,527 words Report 1290LMyeloproliferative neoplasms (MPNs) are characterized by the activated JAK2/STAT pathway. Pleckstrin-2 (Plek2) is a downstream target of the JAK2/STAT5 pathway and is overexpressed in patients with MPNs. We previously...

• The fat is in the lysosome: how Mycobacterium tuberculosis tricks macrophages into storing lipids.

  Authors:Yoann Rombouts and Olivier NeyrollesFrom:Journal of Clinical Investigation (Vol. 133, Issue 6) Peer-Reviewed

  Mar. 15, 20232,225 words Guest commentary 1550LMycobacterium tuberculosis, the causative agent of tuberculosis (TB), infects primarily macrophages, causing them to differentiate into lipid-laden foamy macrophages that are a primary source of tissue destruction in...

• Host immunological responses facilitate development of SARS-CoV-2 mutations in patients receiving monoclonal antibody treatments.

  Authors:Akshita Gupta, Angelina Konnova, Mathias Smet, Matilda Berkell, Alessia Savoldi, Matteo Morra, et al.From:Journal of Clinical Investigation (Vol. 133, Issue 6) Peer-Reviewed

  Mar. 15, 20238,970 words Report 1530LBACKGROUND. The role of host immunity in emergence of evasive SARS-CoV-2 Spike mutations under therapeutic monoclonal antibody (mAb) pressure remains to be explored. METHODS. In a prospective, observational,...

• Clonally expanded HIV-1 proviruses with 5'-leader defects can give rise to nonsuppressible residual viremia.

  Authors:Jennifer A. White, Fengting Wu, Saif Yasin, Milica Moskovljevic, Joseph Varriale, Filippo Dragoni, et al.From:Journal of Clinical Investigation (Vol. 133, Issue 6) Peer-Reviewed

  Mar. 15, 202311,448 words Report 1400LBACKGROUND. Antiretroviral therapy (ART) halts HIV-1 replication, decreasing viremia to below the detection limit of clinical assays. However, some individuals experience persistent nonsuppressible viremia (NSV)...

• Single-cell characterization of anti-LAG-3 and anti-PD-1 combination treatment in patients with melanoma.

  Authors:Jani Huuhtanen, Henna Kasanen, Katriina Peltola, Tapio Lonnberg, Virpi Glumoff, Oscar Bruck, et al.From:Journal of Clinical Investigation (Vol. 133, Issue 6) Peer-Reviewed

  Mar. 15, 202310,776 words Report 1560LBACKGROUND. Relatlimab plus nivolumab (anti-lymphocyte-activation gene 3 plus anti-programmed death 1 [anti- [LAG3.sup.+]anti-PD-1]) has been approved by the FDA as a first-line therapy for stage III/IV melanoma, but its...

• HMGA1 induces FGF19 to drive pancreatic carcinogenesis and stroma formation.

  Authors:Lionel Chia, Bowen Wang, Jung-Hyun Kim, Li Z. Luo, Shuai Shuai, Iliana Herrera, et al.From:Journal of Clinical Investigation (Vol. 133, Issue 6) Peer-Reviewed

  Mar. 15, 202311,218 words Report 1390LHigh mobility group A1 (HMGA1) chromatin regulators are upregulated in diverse tumors where they portend adverse outcomes, although how they function in cancer remains unclear. Pancreatic ductal adenocarcinomas (PDACs)...

• Nonsuppressible viremia during HIV-1 therapy meets molecular virology.

  Authors:Ann Emery, Sarah B. Joseph, and Ronald SwanstromFrom:Journal of Clinical Investigation (Vol. 133, Issue 6) Peer-Reviewed

  Mar. 15, 20232,729 words Guest commentary 1480LHIV-1 replication can be suppressed with antiretroviral therapy (ART), but individuals who stop taking ART soon become viremic again. Some people experience extended times of detectable viremia despite optimal adherence...

• Preclinical and clinical evidence for suppression of alcohol intake by apremilast.

  Authors:Kolter B. Grigsby, Regina A. Mangieri, Amanda J. Roberts, Marcelo F. Lopez, Evan J. Firsick, Kayla G. Townsley, et al.From:Journal of Clinical Investigation (Vol. 133, Issue 6) Peer-Reviewed

  Mar. 15, 20237,152 words Report 1520LTreatment options for alcohol use disorders (AUDs) have minimally advanced since 2004, while the annual deaths and economic toll have increased alarmingly. Phosphodiesterase type 4 (PDE4) is associated with alcohol and...

• Glia in FTLD-CRN: from supporting cast to leading role.

  Authors:Emile S. Pinarbasi and Sami J. BarmadaFrom:Journal of Clinical Investigation (Vol. 133, Issue 6) Peer-Reviewed

  Mar. 15, 20232,543 words Guest commentary 1380LA subset of the neurodegenerative disease frontotemporal lobar degeneration (FTLD) is caused by mutations in the progranulin (GRN) gene. In this issue of the JCI, Marsan and colleagues demonstrate disease-specific...

• A terpene nucleoside from M. tuberculosis induces lysosomal lipid storage in foamy macrophages.

  Authors:Melissa Bedard, Sanne van der Niet, Elliott M. Bernard, Gregory Babunovic, Tan-Yun Cheng, Beren Aylan, et al.From:Journal of Clinical Investigation (Vol. 133, Issue 6) Peer-Reviewed

  Mar. 15, 202311,930 words Report 1450LInduction of lipid-laden foamy macrophages is a cellular hallmark of tuberculosis (TB) disease, which involves the transformation of infected phagolysosomes from a site of killing into a nutrient-rich replicative niche....