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• People.

  From:Nature Biotechnology (Vol. 39, Issue 3) Peer-Reviewed

  Mar. 2021838 words Article 1320LRecent moves of note in and around the biotech and pharma industries. Author Affiliations: Genome editing company Caribou Biosciences has announced the appointment of Jason O'Byrne (photo) as chief financial officer....

• RNA timestamps identify the age of single molecules in RNA sequencing.

  Authors:Samuel G. Rodriques, Linlin M. Chen, Sophia Liu, Ellen D. Zhong, Joseph R. Scherrer, Edward S. Boyden, et al.From:Nature Biotechnology (Vol. 39, Issue 3) Peer-Reviewed

  Mar. 20219,184 words Report 1630LCurrent approaches to single-cell RNA sequencing (RNA-seq) provide only limited information about the dynamics of gene expression. Here we present RNA timestamps, a method for inferring the age of individual RNAs in...

• Club-goers take first bites of lab-made chicken.

  Author:Emily WaltzFrom:Nature Biotechnology (Vol. 39, Issue 3) Peer-Reviewed

  Mar. 20211,536 words Article 1260LSlaughter-free meat grown in bioreactors reaches select diners in Singapore in the form of chicken nuggets. Author(s): Emily Waltz 1 Author Affiliations: (1) Nashville, USA Singapore regulators in December...

• First Rounders: Neil Kumar.

  From:Nature Biotechnology (Vol. 39, Issue 3) Peer-Reviewed

  Mar. 202133 words Brief article 1060LAuthor Affiliations: Neil Kumar is cofounder and CEO of BridgeBio Pharma. He discussed with Nature Biotechnology his youth in the Midwest, the founding principles behind BridgeBio, and understanding where your...

• Balancing clinical evidence in the context of a pandemic.

  Authors:Jacob J. Adashek and Razelle KurzrockFrom:Nature Biotechnology (Vol. 39, Issue 3) Peer-Reviewed

  Mar. 20214,652 words Report 1660LAuthor(s): Jacob J. Adashek 1 , Razelle Kurzrock 2 Author Affiliations: (1) Department of Internal Medicine, University of South Florida, H. Lee Moffitt Cancer Center & Research Institute, Tampa, USA (2) Center for...

• Fully phased human genome assembly without parental data using single-cell strand sequencing and long reads.

  Authors:David Porubsky, Peter Ebert, Peter A. Audano, Mitchell R. Vollger, William T. Harvey, Pierre Marijon, et al.From:Nature Biotechnology (Vol. 39, Issue 3) Peer-Reviewed

  Mar. 20219,111 words Report 1490LHuman genomes are typically assembled as consensus sequences that lack information on parental haplotypes. Here we describe a reference-free workflow for diploid de novo genome assembly that combines the chromosome-wide...

• Bispecific antibodies poised to deliver wave of cancer therapies.

  Author:Cormac SheridanFrom:Nature Biotechnology (Vol. 39, Issue 3) Peer-Reviewed

  Mar. 20212,531 words Article 1250LAn explosion of new formats for bispecific antibodies promises to propel the field to better clinical outcomes in oncology. Author(s): Cormac Sheridan 1 Author Affiliations: (1) Dublin, Ireland The new year...

• Metagenomics.

  From:Nature Biotechnology (Vol. 39, Issue 3) Peer-Reviewed

  Mar. 2021479 words Table Recent patents relating to methods of preparing DNA sequencing libraries for metagenomic analysis and systems for processing metagenomic data. Author Affiliations: US 10,894,979 Sequencing adapters and methods for...

• Plug-and-play control of a brain-computer interface through neural map stabilization.

  Authors:Daniel B. Silversmith, Reza Abiri, Nicholas F. Hardy, Nikhilesh Natraj, Adelyn Tu-Chan, Edward F. Chang, et al.From:Nature Biotechnology (Vol. 39, Issue 3) Peer-Reviewed

  Mar. 202111,795 words Report 1350LBrain-computer interfaces (BCIs) enable control of assistive devices in individuals with severe motor impairments. A limitation of BCIs that has hindered real-world adoption is poor long-term reliability and lengthy...

• Publisher Correction: Light-activated genetic therapy to treat blindness enters clinic.

  Author:Mark RatnerFrom:Nature Biotechnology (Vol. 39, Issue 3) Peer-Reviewed

  Mar. 202179 words Correction notice, B... A Correction to this paper has been published: https://doi.org/10.1038/s41587-021-00871-1. Author(s): Mark Ratner 1 Author Affiliations: (1) Tequesta, USA Correction to: Nature Biotechnology...

• Chromosome-scale, haplotype-resolved assembly of human genomes.

  Authors:Shilpa Garg, Arkarachai Fungtammasan, Andrew Carroll, Mike Chou, Anthony Schmitt, Xiang Zhou, et al.From:Nature Biotechnology (Vol. 39, Issue 3) Peer-Reviewed

  Mar. 20214,038 words Report 1420LHaplotype-resolved or phased genome assembly provides a complete picture of genomes and their complex genetic variations. However, current algorithms for phased assembly either do not generate chromosome-scale phasing or...

• Medical students need artificial intelligence and machine learning training.

  Authors:Aidan Pucchio, Elizabeth A. Eisenhauer, and Fabio Ynoe MoraesFrom:Nature Biotechnology (Vol. 39, Issue 3) Peer-Reviewed

  Mar. 20212,163 words Report 1660LAs the implementation of artificial intelligence and machine learning technologies progresses toward the clinic, the traditional roles of physicians will change. Author(s): Aidan Pucchio 1 , Elizabeth A. Eisenhauer 2 3...

• How large pharma impacts biotechnology startup success.

  Authors:Gina Melchner von Dydiowa, Sander van Deventer, and Daniela S. CoutoFrom:Nature Biotechnology (Vol. 39, Issue 3) Peer-Reviewed

  Mar. 20213,110 words Report 1470LImplications for bioentrepreneurs. Author(s): Gina Melchner von Dydiowa 1 , Sander van Deventer 2 , Daniela S. Couto 1 Author Affiliations: (1) BioGeneration Ventures (BGV), Naarden, the Netherlands (2) Forbion...

• Author Correction: Determination of isoform-specific RNA structure with nanopore long reads.

  Authors:Jong Ghut Ashley Aw, Shaun W. Lim, Jia Xu Wang, Finnlay R. P. Lambert, Wen Ting Tan, Yang Shen, et al.From:Nature Biotechnology (Vol. 39, Issue 3) Peer-Reviewed

  Mar. 2021266 words Correction notice, B... 1940LAn amendment to this paper has been published and can be accessed via a link at the top of the paper. Author(s): Jong Ghut Ashley Aw 1 , Shaun W. Lim 1 , Jia Xu Wang 1 , Finnlay R. P. Lambert 1 2 , Wen Ting Tan 1 ,...

• Green funds for lab-made breast milk.

  From:Nature Biotechnology (Vol. 39, Issue 3) Peer-Reviewed

  Mar. 2021310 words Brief article Author Affiliations: A startup making human breast milk from cultured cells has raised $6.2 million from environmentally focused backers including KBW Ventures, Green Monday Ventures and Eat Beyond Global. The...

• Life sciences intellectual property licensing at the Massachusetts Institute of Technology.

  Authors:Samuel Huang, Kien Wei Siah, Detelina Vasileva, Shirley Chen, Lita Nelsen, and Andrew W. LoFrom:Nature Biotechnology (Vol. 39, Issue 3) Peer-Reviewed

  Mar. 20217,666 words Report 1530LAcademic institutions play a central role in the biotech industry through technology licensing and the creation of startups, but few data are available on their performance and the magnitude of their impact. Here we...

• Mitochondrial copper depletion suppresses triple-negative breast cancer in mice.

  Authors:Liyang Cui, Arvin M. Gouw, Edward L. LaGory, Shenghao Guo, Nabeel Attarwala, Yao Tang, et al.From:Nature Biotechnology (Vol. 39, Issue 3) Peer-Reviewed

  Mar. 202116,130 words Report 1530LDepletion of mitochondrial copper, which shifts metabolism from respiration to glycolysis and reduces energy production, is known to be effective against cancer types that depend on oxidative phosphorylation. However,...

• Determination of isoform-specific RNA structure with nanopore long reads.

  Authors:Jong Ghut Ashley Aw, Shaun W. Lim, Jia Xu Wang, Finnlay R. P. Lambert, Wen Ting Tan, Yang Shen, et al.From:Nature Biotechnology (Vol. 39, Issue 3) Peer-Reviewed

  Mar. 202112,718 words Report 1580LCurrent methods for determining RNA structure with short-read sequencing cannot capture most differences between distinct transcript isoforms. Here we present RNA structure analysis using nanopore sequencing...

• Voices of biotech research.

  Authors:Nasim Annabi, Matthew Baker, Alistair Boettiger, Debojyoti Chakraborty, Yvonne Chen, Kizzmekia S. Corbett, et al.From:Nature Biotechnology (Vol. 39, Issue 3) Peer-Reviewed

  Mar. 20214,300 words Article 1400LNature Biotechnology asks a selection of faculty about the most exciting frontier in their field and the most needed technologies for advancing knowledge and applications. Author(s): Nasim Annabi 1 , Matthew Baker 2 ,...

• Soccer rivals ally over biotech.

  From:Nature Biotechnology (Vol. 39, Issue 3) Peer-Reviewed

  Mar. 2021219 words Brief article 1190LAuthor Affiliations: Argentina, Brazil and Uruguay have set aside their sports rivalry and joined forces to ramp up biotech expertise across Latin America. In December 2020, the three neighboring nations formed the...