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From:Nature Biotechnology (Vol. 39, Issue 4) Peer-ReviewedMetabolomics using nontargeted tandem mass spectrometry can detect thousands of molecules in a biological sample. However, structural molecule annotation is limited to structures present in libraries or databases,...
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From:Nature Biotechnology (Vol. 39, Issue 4) Peer-ReviewedModified versions of existing drugs can substantially increase costs for patients and the health care system if the new version does not offer meaningful clinical improvement. Author(s): Vrushab Gowda 1 2 , Reed F....
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From:Nature Biotechnology (Vol. 39, Issue 4) Peer-ReviewedAuthor Affiliations: Just three weeks after bluebird bio suspended trials of its bb1111 and a related gene therapy due to concerns that its candidates might increase the risk of cancer, the company has reported that...
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From:Nature Biotechnology (Vol. 39, Issue 4) Peer-ReviewedAddressing the needs of women in the life science workforce can improve work-life integration and contribute to a more diverse and inclusive world economy. Author(s): Philip Hockberger 1 2 , Kayla M. Valdes 3 , Jessica...
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From:Nature Biotechnology (Vol. 39, Issue 4) Peer-ReviewedExisting technologies for site-specific integration of kilobase-sized DNA sequences in bacteria are limited by low efficiency, a reliance on recombination, the need for multiple vectors, and challenges in multiplexing....
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From:Nature Biotechnology (Vol. 39, Issue 4) Peer-ReviewedAuthor Affiliations: A Massachusetts-based biotech with a first-in-class bifunctional/trap antibody candidate discovered in India has spun out of Biocon, the Bengaluru-based pharma giant best known for its biosimilars...
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From:Nature Biotechnology (Vol. 39, Issue 4) Peer-ReviewedPrivate biotech firms are awash with funding, raising record-breaking sums in 2020. Melanie Senior reports. Author(s): Melanie Senior 1 Author Affiliations: (1) London, UK Biggest. Best. Worst. Deepest. Almost...
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From:Nature Biotechnology (Vol. 39, Issue 4) Peer-ReviewedAuthor(s): Lisa Melton 1 Author Affiliations: (1) Nature Biotechnology, The first genetically modified chestnut tree now has a thumbs up from Sierra Club, an environmental organization that normally opposes genetic...
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From:Nature Biotechnology (Vol. 39, Issue 4) Peer-ReviewedGenetic linkage causes the fate of new mutations in a population to be contingent on the genetic background on which they appear. This makes it challenging to identify how individual mutations affect fitness. To overcome...
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From:Nature Biotechnology (Vol. 39, Issue 4) Peer-ReviewedAuthor(s): Shawn S. Jackson 1 , Louise E. Sumner 1 , Rocco J. Casagrande 1 Author Affiliations: (1) Gryphon Scientific, LLC, Takoma Park, USA S. S. Jackson et al. reply -- Our Correspondence was written with a...
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From:Nature Biotechnology (Vol. 39, Issue 4) Peer-ReviewedConventional targeted sequencing methods eliminate many of the benefits of nanopore sequencing, such as the ability to accurately detect structural variants or epigenetic modifications. The ReadUntil method allows...
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From:Nature Biotechnology (Vol. 39, Issue 4) Peer-ReviewedNatural mitochondrial DNA (mtDNA) mutations enable the inference of clonal relationships among cells. mtDNA can be profiled along with measures of cell state, but has not yet been combined with the massively parallel...
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From:Nature Biotechnology (Vol. 39, Issue 4) Peer-ReviewedAuthor(s): Koen Beumer 1 Author Affiliations: (1) Copernicus Institute of Sustainable Development-Innovation Studies, Utrecht University, Utrecht, the Netherlands To the Editor -- In their Correspondence "The...
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From:Nature Biotechnology (Vol. 39, Issue 4) Peer-ReviewedThe reconstruction of bacterial and archaeal genomes from shotgun metagenomes has enabled insights into the ecology and evolution of environmental and host-associated microbiomes. Here we applied this approach to >10,000...
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From:Nature Biotechnology (Vol. 39, Issue 4) Peer-ReviewedAn amendment to this paper has been published and can be accessed via a link at the top of the paper. Author(s): Stephen Nayfach 1 , Simon Roux 1 , Rekha Seshadri 1 , Daniel Udwary 1 , Neha Varghese 1 , Frederik Schulz...
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From:Nature Biotechnology (Vol. 39, Issue 4) Peer-ReviewedRecent moves of note in and around the biotech and pharma industries. Author Affiliations: Paris-based clinical-stage company Abivax has announced the appointment of Sophie Biguenet (photo) as chief medical officer,...
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From:Nature Biotechnology (Vol. 39, Issue 4) Peer-ReviewedRecent patents relating to the production of cells, tissues and animals for use in the field of xenotransplantation. Author Affiliations: US 10,912,863 Tissues derived from animals, which lack any expression of...
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From:Nature Biotechnology (Vol. 39, Issue 4) Peer-ReviewedNanopore sequencers can be used to selectively sequence certain DNA molecules in a pool by reversing the voltage across individual nanopores to reject specific sequences, enabling enrichment and depletion to address...
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From:Nature Biotechnology (Vol. 39, Issue 4) Peer-ReviewedThe US RADx program has spawned a phalanx of diagnostic products to market in just 12 months. Its long-term impact on point-of-care, at-home and population testing may be even more profound. Author Affiliations: Over...
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From:Nature Biotechnology (Vol. 39, Issue 4) Peer-ReviewedAuthor(s): Joseph R. Brady 1 2 , J. Christopher Love 1 2 Author Affiliations: (1) Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, USA (2) Department of Chemical...