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From:Nature Biotechnology (Vol. 39, Issue 7) Peer-ReviewedVascular complications following solid organ transplantation may lead to graft ischemia, dysfunction or loss. Imaging approaches can provide intermittent assessments of graft perfusion, but require highly skilled...
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From:Nature Biotechnology (Vol. 39, Issue 7) Peer-ReviewedAuthor Affiliations: In June, stalwart German biotech MorphoSys cemented its future as a commercial-stage company through the $1.7 billion acquisition of US epigenetics company Constellation Pharmaceuticals and an...
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From:Nature Biotechnology (Vol. 39, Issue 7) Peer-ReviewedAuthor(s): Elie Dolgin 1 Author Affiliations: (1) Somerville, USA Correction to: Nature Biotechnology https://doi.org/10.1038/s41587-021-00980-x, published online 22 June 2021. In the version of this article...
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From:Nature Biotechnology (Vol. 39, Issue 7) Peer-ReviewedAlmost all haplotype-based variant callers were designed specifically for detecting common germline variation in diploid populations, and give suboptimal results in other scenarios. Here we present Octopus, a variant...
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From:Nature Biotechnology (Vol. 39, Issue 7) Peer-ReviewedIn contrast to single-cell approaches for measuring gene expression and DNA accessibility, single-cell methods for analyzing histone modifications are limited by low sensitivity and throughput. Here, we combine the...
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From:Nature Biotechnology (Vol. 39, Issue 7) Peer-ReviewedAuthor Affiliations: Novavax has unveiled results from a large clinical trial showing that its vaccine is 90.4% effective in preventing symptomatic COVID-19 and 100% protective against moderate and severe disease....
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From:Nature Biotechnology (Vol. 39, Issue 7) Peer-ReviewedA new dimension for analyzing mass spectrometry data allows rapid quantification of up to 70% more peptides. Author(s): Nikolai Slavov 1 2 Author Affiliations: (1) Department of Bioengineering, Northeastern...
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From:Nature Biotechnology (Vol. 39, Issue 7) Peer-ReviewedRecent moves of note in and around the biotech and pharma industries. Author Affiliations: Monte Rosa Therapeutics has announced the appointment of Filip Janku (photo) as the company's first chief medical officer....
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From:Nature Biotechnology (Vol. 39, Issue 7) Peer-ReviewedA malaria vaccine not only has achieved record-setting protection in a large trial, but also spurred the UK's COVID-19 vaccine effort. Author(s): Heidi Ledford 1 Author Affiliations: (1) London, UK A large...
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From:Nature Biotechnology (Vol. 39, Issue 7) Peer-ReviewedCompanies are designing next-generation antibodies modeled on those taken from unique individuals whose immune systems can neutralize any COVID-19 variant--and related coronaviruses, too. Author(s): Elie Dolgin 1...
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From:Nature Biotechnology (Vol. 39, Issue 7) Peer-ReviewedFull-length circular RNAs are sequenced at high throughput using nanopores. Author(s): Zhao Zhang 1 2 , Leng Han 2 3 Author Affiliations: (1) MOE Key Laboratory of Metabolism and Molecular Medicine, Department of...
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From:Nature Biotechnology (Vol. 39, Issue 7) Peer-ReviewedA survey of patenting activity can facilitate coordination of R&D activities to fight emerging infectious diseases. Author(s): Nasir Mohajel 1, Arash Arashkia 1 Author Affiliations: (1) Department of Molecular...
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From:Nature Biotechnology (Vol. 39, Issue 7) Peer-ReviewedReconstructing the sequence of circular RNAs (circRNAs) from short RNA sequencing reads has proved challenging given the similarity of circRNAs and their corresponding linear messenger RNAs. Previous sequencing methods...
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From:Nature Biotechnology (Vol. 39, Issue 7) Peer-ReviewedChina's growing influence in biotech was underscored in 2020 during a record-breaking year for sector financing. Author(s): Melanie Senior 1 Author Affiliations: (1) London, UK 2020 will be remembered in...
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From:Nature Biotechnology (Vol. 39, Issue 7) Peer-ReviewedRecent patents relating to microbiome modulation and analysis, and the formulation of live biotherapeutics. Author Affiliations: Patent number Description Assignee Inventor Date US 10,980,845 Probiotic...
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From:Nature Biotechnology (Vol. 39, Issue 7) Peer-ReviewedAuthor(s): Koko Kwisda 1 2 , Tobias Cantz 2 3 , Nils Hoppe 1 2 Author Affiliations: (1) CELLS - Centre for Ethics and Law in the Life Sciences, Leibniz University Hannover, Hannover, Germany (2) REBIRTH-AG...
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From:Nature Biotechnology (Vol. 39, Issue 7) Peer-ReviewedAn Alzheimer's drug approval is being touted as a triumph for patients. But US healthcare is ill prepared for Aduhelm's questionable efficacy, unfettered market access and high price. Author Affiliations: Aduhelm...
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From:Nature Biotechnology (Vol. 39, Issue 7) Peer-ReviewedAccurate quantification of the proteome remains challenging for large sample series and longitudinal experiments. We report a data-independent acquisition method, Scanning SWATH, that accelerates mass spectrometric (MS)...
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From:Nature Biotechnology (Vol. 39, Issue 7) Peer-ReviewedMethods for quantifying gene expression.sup.1 and chromatin accessibility.sup.2 in single cells are well established, but single-cell analysis of chromatin regions with specific histone modifications has been technically...
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From:Nature Biotechnology (Vol. 39, Issue 7) Peer-ReviewedMolecular differences between individual cells can lead to dramatic differences in cell fate, such as death versus survival of cancer cells upon drug treatment. These originating differences remain largely hidden due to...