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From:Nature Biotechnology (Vol. 39, Issue 8) Peer-ReviewedSeveral techniques are currently being developed for spatially resolved omics profiling, but each new method requires the setup of specific detection strategies or specialized instrumentation. Here we describe an...
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From:Nature Biotechnology (Vol. 39, Issue 8) Peer-ReviewedAn analysis of sectoral differences in gender pay gap over career lifecycles reveals that academia has a wider gender pay gap relative to industry. Author(s): Waverly W. Ding 1 , Atsushi Ohyama 2 , Rajshree Agarwal 1...
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From:Nature Biotechnology (Vol. 39, Issue 8) Peer-ReviewedEmbryo models built from stem cells promise to shed light on human development. Author(s): Mina Popovic 1 , Felicitas Azpiroz 1 2 , Susana M. Chuva de Sousa Lopes 3 4 Author Affiliations: (1) Clínica Eugin,...
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From:Nature Biotechnology (Vol. 39, Issue 8) Peer-ReviewedThe International Society for Stem Cell Research has called for broad public dialogue on the ethics of human embryo research beyond 14 days post-fertilization. National jurisdictions should seize the moment. Author...
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From:Nature Biotechnology (Vol. 39, Issue 8) Peer-ReviewedWith the risks of drug development prohibitive, repurposed or repositioned medicines appear the best hope against long-COVID, a condition that still raises many unanswered questions. Author(s): Charles Schmidt 1...
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From:Nature Biotechnology (Vol. 39, Issue 8) Peer-ReviewedRecent methods for spatial imaging of tissue samples can identify up to ~100 individual proteins.sup.1-3 or RNAs.sup.4-10 at single-cell resolution. However, the number of proteins or genes that can be studied in these...
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From:Nature Biotechnology (Vol. 39, Issue 8) Peer-ReviewedAuthor(s): Laura DeFrancesco 1 Author Affiliations: (1) Senior Editor, Nature Biotechnology, Financing took a downward turn, with the exception of venture funding, which held steady overall, although the amount...
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From:Nature Biotechnology (Vol. 39, Issue 8) Peer-ReviewedPlasma-derived polyclonal antibody therapeutics, such as intravenous immunoglobulin, have multiple drawbacks, including low potency, impurities, insufficient supply and batch-to-batch variation. Here we describe a...
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From:Nature Biotechnology (Vol. 39, Issue 8) Peer-ReviewedChinese upstart companies and IT goliaths hope to turn country's artificial intelligence prowess into world-leading drug innovation. Do they have an edge over Western players? Author(s): David Cyranoski 1 Author...
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From:Nature Biotechnology (Vol. 39, Issue 8) Peer-ReviewedPrime editing (PE) applications are limited by low editing efficiency. Here we show that designing prime binding sites with a melting temperature of 30 °C leads to optimal performance in rice and that using two prime...
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From:Nature Biotechnology (Vol. 39, Issue 8) Peer-ReviewedAuthor Affiliations: Biotech startup Pairwise Plants has launched field trials in the US Midwest, with backing from Bayer Crop Science, of corn with more kernel rows. The genetically edited corn, obtained with CRISPR...
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From:Nature Biotechnology (Vol. 39, Issue 8) Peer-ReviewedCurrent serology tests for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies mainly take the form of enzyme-linked immunosorbent assays, chemiluminescent microparticle immunoassays or lateral flow...
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From:Nature Biotechnology (Vol. 39, Issue 8) Peer-ReviewedIntegrating large single-cell gene expression, chromatin accessibility and DNA methylation datasets requires general and scalable computational approaches. Here we describe online integrative non-negative matrix...
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From:Nature Biotechnology (Vol. 39, Issue 8) Peer-ReviewedAuthor(s): Cormac Sheridan 1 Author Affiliations: (1) Dublin, Ireland, Correction to: Nature Biotechnology https://doi.org/10.1038/s41587-021-00955-y, published online 10 June 2021. In the version of this article...
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From:Nature Biotechnology (Vol. 39, Issue 8) Peer-ReviewedAuthor(s): Laura DeFrancesco 1 Author Affiliations: (1) Senior Editor, Nature Biotechnology, Accelerated, rather than full, approvals were prominent. As usual, cancer registrations predominated--including Amgen's...
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From:Nature Biotechnology (Vol. 39, Issue 8) Peer-ReviewedMost known pathogenic point mutations in humans are C*G to T*A substitutions, which can be directly repaired by adenine base editors (ABEs). In this study, we investigated the efficacy and safety of ABEs in the livers of...
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From:Nature Biotechnology (Vol. 39, Issue 8) Peer-ReviewedCurrent next-generation RNA-sequencing (RNA-seq) methods do not provide accurate quantification of small RNAs within a sample, due to sequence-dependent biases in capture, ligation and amplification during library...
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From:Nature Biotechnology (Vol. 39, Issue 8) Peer-ReviewedRecent patents relating to the introduction of single-nucleotide variants into DNA or RNA in living cells. Author Affiliations: US 10,975,364 A modified S. aureus Cas9 (SaCas9) protein with a mutation at an N413...
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From:Nature Biotechnology (Vol. 39, Issue 8) Peer-ReviewedDespite substantial progress in single-cell RNA-seq (scRNA-seq) data analysis methods, there is still little agreement on how to best normalize such data. Starting from the basic requirements that inferred expression...
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From:Nature Biotechnology (Vol. 39, Issue 8) Peer-ReviewedAuthor Affiliations: More than two years after the birth of twin girls with edited genomes, an advisory panel for the World Health Organization (WHO) has issued new recommendations that uphold the agency's initial...