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• Learning on knowledge graph dynamics provides an early warning of impactful research.

  Authors:James W. Weis and Joseph M. JacobsonFrom:Nature Biotechnology (Vol. 39, Issue 10) Peer-Reviewed

  Oct. 20216,767 words Report 1650LThe scientific ecosystem relies on citation-based metrics that provide only imperfect, inconsistent and easily manipulated measures of research quality. Here we describe DELPHI (Dynamic Early-warning by Learning to...

• Synthetic biology.

  From:Nature Biotechnology (Vol. 39, Issue 10) Peer-Reviewed

  Oct. 2021576 words Table Recent patents relating to synthetic nucleotides, peptides and genomes. Author Affiliations: US 11,110,195 Synthetic antibacterial peptides that have a sequence at least 80% identical to a sequence shown in SEQ ID...

• Integrative single-cell analysis of allele-specific copy number alterations and chromatin accessibility in cancer.

  Authors:Chi-Yun Wu, Billy T. Lau, Heon Seok Kim, Anuja Sathe, Susan M. Grimes, Hanlee P. Ji, et al.From:Nature Biotechnology (Vol. 39, Issue 10) Peer-Reviewed

  Oct. 202111,478 words Report 1560LCancer progression is driven by both somatic copy number aberrations (CNAs) and chromatin remodeling, yet little is known about the interplay between these two classes of events in shaping the clonal diversity of...

• Profiling the genetic determinants of chromatin accessibility with scalable single-cell CRISPR screens.

  Authors:Noa Liscovitch-Brauer, Antonino Montalbano, Jiale Deng, Alejandro Méndez-Mancilla, Hans-Hermann Wessels, Nicholas G. Moss, et al.From:Nature Biotechnology (Vol. 39, Issue 10) Peer-Reviewed

  Oct. 202111,425 words Report 1520LCRISPR screens have been used to connect genetic perturbations with changes in gene expression and phenotypes. Here we describe a CRISPR-based, single-cell combinatorial indexing assay for transposase-accessible...

• Ready-to-use public infrastructure for global SARS-CoV-2 monitoring.

  Authors:Wolfgang Maier, Simon Bray, Marius van den Beek, Dave Bouvier, Nathan Coraor, Milad Miladi, et al.From:Nature Biotechnology (Vol. 39, Issue 10) Peer-Reviewed

  Oct. 20211,197 words Report 1630LAuthor(s): Wolfgang Maier 1 , Simon Bray 1 , Marius van den Beek 2 , Dave Bouvier 2 , Nathan Coraor 2 , Milad Miladi 1 , Babita Singh 3 , Jordi Rambla De Argila 3 , Dannon Baker 4 , Nathan Roach 5 , Simon Gladman 6 ,...

• Synthetic virology: the experts speak.

  Author:Laura DeFrancescoFrom:Nature Biotechnology (Vol. 39, Issue 10) Peer-Reviewed

  Oct. 20218,250 words Discussion 1280LEven though only a few labs around the world have the means to engineer a purely synthetic virus, debate on the origins of SARS-CoV-2 has resurfaced concerns about the risks and benefits of synthetic virology....

• UK trials first CRISPR-edited wheat in Europe.

  From:Nature Biotechnology (Vol. 39, Issue 10) Peer-Reviewed

  Oct. 2021251 words Brief article 1730LAuthor Affiliations: In a sign of the United Kingdom's intentions to move away from European Union (EU) restrictions following Brexit, its Department for Environment, Food & Rural Affairs (DEFRA) has given scientists...

• Publisher Correction: Send in the senolytics.

  Author:Elie DolginFrom:Nature Biotechnology (Vol. 39, Issue 10) Peer-Reviewed

  Oct. 202191 words Correction notice, B... 2140LAuthor(s): Elie Dolgin 1 Author Affiliations: (1) Somerville, USA Correction to: Nature Biotechnology https://doi.org/10.1038/s41587-020-00750-1, published online 12 November 2020. In this News Feature, a...

• The champions of drug development.

  From:Nature Biotechnology (Vol. 39, Issue 10) Peer-Reviewed

  Oct. 2021965 words Article 1250LOur new podcast series 'Hope Lies in Dreams' highlights the importance of visionaries in shepherding drugs through the setbacks of drug development to commercial success. Author Affiliations: Drug development is a...

• Scalable, multimodal profiling of chromatin accessibility, gene expression and protein levels in single cells.

  Authors:Eleni P. Mimitou, Caleb A. Lareau, Kelvin Y. Chen, Andre L. Zorzetto-Fernandes, Yuhan Hao, Yusuke Takeshima, et al.From:Nature Biotechnology (Vol. 39, Issue 10) Peer-Reviewed

  Oct. 202116,410 words Report 1640LRecent technological advances have enabled massively parallel chromatin profiling with scATAC-seq (single-cell assay for transposase accessible chromatin by sequencing). Here we present ATAC with select antigen profiling...

• Rapid delivery systems for future food security.

  Authors:Rajeev K. Varshney, Abhishek Bohra, Manish Roorkiwal, Rutwik Barmukh, Wallace Cowling, Annapurna Chitikineni, et al.From:Nature Biotechnology (Vol. 39, Issue 10) Peer-Reviewed

  Oct. 20212,147 words Report 1570LAuthor(s): Rajeev K. Varshney 1 2 3 , Abhishek Bohra 4 , Manish Roorkiwal 1 3 , Rutwik Barmukh 1 , Wallace Cowling 3 , Annapurna Chitikineni 1 , Hon-Ming Lam 5 , Lee T. Hickey 6 , Janine Croser 3 7 , David Edwards 3 8 ,...

• Genome-wide specificity of prime editors in plants.

  Authors:Shuai Jin, Qiupeng Lin, Yingfeng Luo, Zixu Zhu, Guanwen Liu, Yunjia Li, et al.From:Nature Biotechnology (Vol. 39, Issue 10) Peer-Reviewed

  Oct. 20217,708 words Report 1490LAlthough prime editors (PEs) have the potential to facilitate precise genome editing in therapeutic, agricultural and research applications, their specificity has not been comprehensively evaluated. To provide a...

• Nanotechnology offers alternative ways to fight COVID-19 pandemic with antivirals.

  Author:Mark PeplowFrom:Nature Biotechnology (Vol. 39, Issue 10) Peer-Reviewed

  Oct. 20212,091 words Article 1380LA new wave of funding focuses on antiviral nanomaterials as pandemic countermeasures. Author(s): Mark Peplow 1 Author Affiliations: (1) Penrith, UK A flurry of recent papers highlights growing interest in...

• Roche deal with RNA-editing spinout.

  From:Nature Biotechnology (Vol. 39, Issue 10) Peer-Reviewed

  Oct. 2021205 words Brief article 1080LAuthor Affiliations: Shape Therapeutics has announced a $3-billion multi-target collaboration with Roche. The two-year-old Seattle-based biotech is developing a platform for designing and delivering base editors of RNA...

• Improving scientific communication with service, education and career development.

  Authors:Amanda Dicks, Himanshi Bhatia, Adam W. Clemens, Marissa C. Locke, Elizabeth A. Mueller, Daniel Murphy, et al.From:Nature Biotechnology (Vol. 39, Issue 10) Peer-Reviewed

  Oct. 20213,684 words Report 1420LA trainee-run group that provides editing and schema design services not only enhances scientific communication for clients, but also trains its members in communication, writing and other transferrable skills....

• Church to de-extinct woolly mammoths.

  Author:Laura DeFrancescoFrom:Nature Biotechnology (Vol. 39, Issue 10) Peer-Reviewed

  Oct. 2021301 words Brief article 1410LAuthor(s): Laura DeFrancesco 1 Author Affiliations: (1) Nature Biotechnology, Harvard Medical School's George Church has launched Colossal, his latest venture, with a mission to bring woolly mammoths back to life....

• Fully implantable and bioresorbable cardiac pacemakers without leads or batteries.

  Authors:Yeon Sik Choi, Rose T. Yin, Anna Pfenniger, Jahyun Koo, Raudel Avila, K. Benjamin Lee, et al.From:Nature Biotechnology (Vol. 39, Issue 10) Peer-Reviewed

  Oct. 202112,623 words Report 1490LTemporary cardiac pacemakers used in periods of need during surgical recovery involve percutaneous leads and externalized hardware that carry risks of infection, constrain patient mobility and may damage the heart during...

• Biotech patenting 2020.

  Authors:Brady Huggett and Kathryn PaisnerFrom:Nature Biotechnology (Vol. 39, Issue 10) Peer-Reviewed

  Oct. 2021694 words Table 1070LAuthor(s): Brady Huggett 1 , Kathryn Paisner 2 Author Affiliations: (1) Senior Editor, Nature Biotechnology, (2) Oakland, USA The biotech patent literature continues to expand (Fig. 1), although growth in 2020...

• Drug hunters uncloak the non-coding 'hidden' genome.

  Author:Michael EisensteinFrom:Nature Biotechnology (Vol. 39, Issue 10) Peer-Reviewed

  Oct. 20211,974 words Article 1490LScientists are using new tools to mine the non-coding part of the genome, known as 'dark matter', to uncover disease-linked changes in promoters, silencers and enhancers for target discovery. Author(s): Michael...

• Quantitative profiling of pseudouridylation dynamics in native RNAs with nanopore sequencing.

  Authors:Oguzhan Begik, Morghan C. Lucas, Leszek P. Pryszcz, Jose Miguel Ramirez, Rebeca Medina, Ivan Milenkovic, et al.From:Nature Biotechnology (Vol. 39, Issue 10) Peer-Reviewed

  Oct. 202115,730 words Report 1660LNanopore RNA sequencing shows promise as a method for discriminating and identifying different RNA modifications in native RNA. Expanding on the ability of nanopore sequencing to detect N.sup.6-methyladenosine, we show...