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    Academic Journals

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• NINDS launches network to develop treatments for ultra-rare neurological diseases.

  Authors:Nina F. Schor, Amir P. Tamiz, Walter J. Koroshetz, Julia L. Bachman, Chris Boshoff, Janice Cordell, et al.From:Nature Biotechnology (Vol. 39, Issue 12) Peer-Reviewed

  Dec. 20211,847 words Article 1560LAuthor(s): Nina F. Schor 1 , Amir P. Tamiz 1 , Walter J. Koroshetz 1 , Julia L. Bachman 1 , Chris Boshoff 1 , Janice Cordell 1 , Neel T. Dhruv 1 , Amelie Gubitz 1 , Adam L. Hartman 1 , Genevieve E. Lind 1 , Codrin I....

• Nanopore sequencing of single-cell transcriptomes with scCOLOR-seq.

  Authors:Martin Philpott, Jonathan Watson, Anjan Thakurta, Tom Brown, Jr., Tom Brown, Sr., Udo Oppermann, et al.From:Nature Biotechnology (Vol. 39, Issue 12) Peer-Reviewed

  Dec. 20215,609 words Report 1630LHere we describe single-cell corrected long-read sequencing (scCOLOR-seq), which enables error correction of barcode and unique molecular identifier oligonucleotide sequences and permits standalone cDNA nanopore...

• MaxDIA enables library-based and library-free data-independent acquisition proteomics.

  Authors:Pavel Sinitcyn, Hamid Hamzeiy, Favio Salinas Soto, Daniel Itzhak, Frank McCarthy, Christoph Wichmann, et al.From:Nature Biotechnology (Vol. 39, Issue 12) Peer-Reviewed

  Dec. 202110,931 words Article 1550LMaxDIA is a software platform for analyzing data-independent acquisition (DIA) proteomics data within the MaxQuant software environment. Using spectral libraries, MaxDIA achieves deep proteome coverage with substantially...

• Author Correction: Stepping to the exit.

  Authors:Christiaan M. de Bloeme, Robin W. Jansen, Mark R. L. Krul, and Ernst-Jan GeutjesFrom:Nature Biotechnology (Vol. 39, Issue 12) Peer-Reviewed

  Dec. 2021139 words Correction notice, B... 1610LAuthor(s): Christiaan M. de Bloeme 1 , Robin W. Jansen 1 , Mark R. L. Krul 1 , Ernst-Jan Geutjes 1 Author Affiliations: (1) Aglaia Oncology Funds, Bilthoven, the Netherlands Correction to: Nature Biotechnology...

• Technologies to advance COVID-19 vaccine equity.

  From:Nature Biotechnology (Vol. 39, Issue 12) Peer-Reviewed

  Dec. 2021968 words Article 1530LPoor countries need vaccine formats with low barriers to manufacture, distribution and administration. Author Affiliations: The COVID-19 pandemic is likely to ricochet around the world for years to come. One year...

• RNA delivery with a human virus-like particle.

  Authors:Anna Gutkin, Daniel Rosenblum, and Dan PeerFrom:Nature Biotechnology (Vol. 39, Issue 12) Peer-Reviewed

  Dec. 20211,387 words Report 1510LRNA cargo is transferred into cultured cells using a fully human delivery system. Author(s): Anna Gutkin 1 2 3 , Daniel Rosenblum 4 , Dan Peer 1 2 3 Author Affiliations: (1) Laboratory of Precision Nanomedicine,...

• Improving CRISPR tools by elucidating DNA repair.

  Authors:Jung Min Lim and Hyongbum Henry KimFrom:Nature Biotechnology (Vol. 39, Issue 12) Peer-Reviewed

  Dec. 20211,698 words Article 1590LGenome-editing tools are optimized by identifying genes that affect DNA repair. Author(s): Jung Min Lim 1 , Hyongbum Henry Kim 1 2 Author Affiliations: (1) Department of Pharmacology, Yonsei University College of...

• 100,000 whole-genome sequences' diagnostic bonus.

  From:Nature Biotechnology (Vol. 39, Issue 12) Peer-Reviewed

  Dec. 2021284 words Brief article 1400LAuthor Affiliations: Early data from the 100,000 Genomes Project reveal to what extent patients with undiagnosed rare diseases can end their diagnostic odysseys by having their whole genomes sequenced. For the pilot...

• The CRISPR children.

  Author:Vivien MarxFrom:Nature Biotechnology (Vol. 39, Issue 12) Peer-Reviewed

  Dec. 20214,034 words Article 1330LIn China, the first children with germline-edited genomes are growing up. How might their edited genomes affect their lives? Author(s): Vivien Marx 1 Author Affiliations: (1) New York, USA Three years after the...

• High-throughput mapping of a whole rhesus monkey brain at micrometer resolution.

  Authors:Fang Xu, Yan Shen, Lufeng Ding, Chao-Yu Yang, Heng Tan, Hao Wang, et al.From:Nature Biotechnology (Vol. 39, Issue 12) Peer-Reviewed

  Dec. 202111,616 words Report 1590LWhole-brain mesoscale mapping in primates has been hindered by large brain sizes and the relatively low throughput of available microscopy methods. Here, we present an approach that combines primate-optimized tissue...

• Wearable devices.

  From:Nature Biotechnology (Vol. 39, Issue 12) Peer-Reviewed

  Dec. 2021619 words Table Recent patents relating to wearable technology and devices for patient monitoring and treatment. Author Affiliations: US 11,160,503 A system for monitoring a vascular access, including a wearable vascular access...

• Cholesterol-functionalized DNA/RNA heteroduplexes cross the blood-brain barrier and knock down genes in the rodent CNS.

  Authors:Tetsuya Nagata, Chrissa A. Dwyer, Kie Yoshida-Tanaka, Kensuke Ihara, Masaki Ohyagi, Hidetoshi Kaburagi, et al.From:Nature Biotechnology (Vol. 39, Issue 12) Peer-Reviewed

  Dec. 20219,924 words Report 1630LAchieving regulation of endogenous gene expression in the central nervous system (CNS) with antisense oligonucleotides (ASOs) administered systemically would facilitate the development of ASO-based therapies for...

• Cellular meat gets first government investment.

  From:Nature Biotechnology (Vol. 39, Issue 12) Peer-Reviewed

  Dec. 2021222 words Brief article 1250LAuthor Affiliations: The US Department of Agriculture (USDA) has created a new center for exploring cultivated meat approaches as part of its $146-million program for sustainable agricultural research. With a...

• No bones, no scales, no eyeballs: appetite grows for cell-based seafood.

  Author:Emily WaltzFrom:Nature Biotechnology (Vol. 39, Issue 12) Peer-Reviewed

  Dec. 20211,911 words Article 1300LLab-grown fish taste the same as their wild and farmed counterparts, offering an alternative to traditional seafood. But will it ever make economic sense to produce this kind of protein? Lab-grown fish taste the same...

• Preparing for the next plague.

  Author:Laura DeFrancescoFrom:Nature Biotechnology (Vol. 39, Issue 12) Peer-Reviewed

  Dec. 20215,016 words Article 1530LWhether pan-vaccines or antibodies, SARS-CoV-2 is adding impetus to the race for broad-spectrum countermeasures against the world's next infectious scourges. Author(s): Laura DeFrancesco 1 Author Affiliations: (1)...

• International standards and guidelines for xenotransplantation.

  Authors:Wayne J. Hawthorne, Peter J. Cowan, Leo Buhler, and Eckhard WolfFrom:Nature Biotechnology (Vol. 39, Issue 12) Peer-Reviewed

  Dec. 20211,035 words Article 1560LAuthor(s): Wayne J. Hawthorne 1 2 , Peter J. Cowan 3 , Leo Buhler 4 , Eckhard Wolf 5 Author Affiliations: (1) Department of Surgery, School of Medical Sciences, Faculty of Medicine and Health, University of Sydney,...

• Combination therapy patents: a new front in evergreening.

  Authors:Garth W. Strohbehn, Alec J. Kacew, Daniel A. Goldstein, Robin C. Feldman, and Mark J. RatainFrom:Nature Biotechnology (Vol. 39, Issue 12) Peer-Reviewed

  Dec. 20216,557 words Report 1580LAs pharmaceutical companies seek patent protection for combinations of cancer therapeutics, it is worthwhile to assess what constitutes an 'unexpected result' for the purpose of an appropriate patent and whether...

• RNA demethylation increases the yield and biomass of rice and potato plants in field trials.

  Authors:Qiong Yu, Shun Liu, Lu Yu, Yu Xiao, Shasha Zhang, Xueping Wang, et al.From:Nature Biotechnology (Vol. 39, Issue 12) Peer-Reviewed

  Dec. 202111,148 words Report 1640LRNA N.sup.6-methyladenosine (m.sup.6A) modifications are essential in plants. Here, we show that transgenic expression of the human RNA demethylase FTO in rice caused a more than threefold increase in grain yield under...

• Publisher Correction: Roche deal with RNA-editing spinout.

  From:Nature Biotechnology (Vol. 39, Issue 12) Peer-Reviewed

  Dec. 202161 words Correction notice, B... 830LAuthor Affiliations: Correction to: Nature Biotechnology https://doi.org/10.1038/s41587-021-01097-x, published online 7 October 2021. In the version of this article initially published, there was an error in the...

• People.

  From:Nature Biotechnology (Vol. 39, Issue 12) Peer-Reviewed

  Dec. 2021844 words Article 1310LRecent moves of note in and around the biotech and pharma industries. Author Affiliations: Lausanne, Switzerland-based Oculis has announced the appointment of Joanne Chang (photo) as chief medical officer and head of...