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    Academic Journals

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• Microbiome transplant-induced response to immunotherapy.

  Author:Hannah StowerFrom:Nature Medicine (Vol. 27, Issue 1) Peer-Reviewed

  Jan. 2021134 words Brief article 1260LAuthor(s): Hannah Stower 1 Author Affiliations: (1) Nature Medicine, Sciencehttps://doi.org/10.1126/science.abb5920 (2020) A fecal microbiome transplant has shown the potential to induce a response to...

• Artificial intelligence for disparities in knee pain assessment

  Author:Said A. IbrahimFrom:Nature Medicine (Vol. 27, Issue 1) Peer-Reviewed

  Jan. 20211,383 words Article 1380LAn algorithm developed through machine learning on existing radiological data from diverse people has the potential to improve the diagnosis and management of knee pain from osteoarthritis and reduce racial disparities...

• Treatment of one eye affects both.

  Author:Hannah StowerFrom:Nature Medicine (Vol. 27, Issue 1) Peer-Reviewed

  Jan. 2021179 words Brief article 1280LAuthor(s): Hannah Stower 1 Author Affiliations: (1) Nature Medicine, Sci. Transl. Med. 12, eaaz7423 (2020) The injection of a gene-therapy treatment for Leber hereditary optic neuropathy (LHON) into only the...

• Cabozantinib for neurofibromatosis type 1-related plexiform neurofibromas: a phase 2 trial

  Authors:Michael J. Fisher, Chie-Schin Shih, Steven D. Rhodes, Amy E. Armstrong, Pamela L. Wolters, Eva Dombi, et al.From:Nature Medicine (Vol. 27, Issue 1) Peer-Reviewed

  Jan. 202114,505 words Report 1540LNeurofibromatosis type 1 (NF1) plexiform neurofibromas (PNs) are progressive, multicellular neoplasms that cause morbidity and may transform to sarcoma. Treatment of Nf1.sup.fl/fl;Postn-Cre mice with cabozantinib, an...

• Toward superhuman SARS-CoV-2 immunity?

  Authors:Dennis R. Burton and Eric J. TopolFrom:Nature Medicine (Vol. 27, Issue 1) Peer-Reviewed

  Jan. 20211,319 words Letter to the editor 1420LAuthor(s): Dennis R. Burton 1 2 , Eric J. Topol 1 3 Author Affiliations: (1) The Scripps Research Institute, La Jolla, USA (2) Ragon Institute of MGH, Harvard and MIT, Cambridge, USA (3) Scripps...

• On the origins of SARS-CoV-2

  Author:Angela L. RasmussenFrom:Nature Medicine (Vol. 27, Issue 1) Peer-Reviewed

  Jan. 2021943 words Article 1630LStakeholders in public health must lobby policy makers to make decisions based on evidence, not political expediency, particularly when the studies that hang in the balance are critical to understanding the origins of...

• Pathophysiology-based subphenotyping of individuals at elevated risk for type 2 diabetes

  Authors:Robert Wagner, Martin Heni, Adam G. Tabak, Jurgen Machann, Fritz Schick, Elko Randrianarisoa, et al.From:Nature Medicine (Vol. 27, Issue 1) Peer-Reviewed

  Jan. 20219,506 words Report 1480LThe state of intermediate hyperglycemia is indicative of elevated risk of developing type 2 diabetes.sup.1. However, the current definition of prediabetes neither reflects subphenotypes of pathophysiology of type 2...

• Air pollution linked to neurodegeneration markers.

  Author:Hannah StowerFrom:Nature Medicine (Vol. 27, Issue 1) Peer-Reviewed

  Jan. 2021139 words Brief article 1350LAuthor(s): Hannah Stower 1 Author Affiliations: (1) Nature Medicine, JAMA Neurol. https://doi.org/10.1001/jamaneurol.2020.3962 (2020) Exposure to air pollution is linked to the presence of amyloid-[beta] plaques...

• Eight ways machine learning is assisting medicine

  Author:Mike MayFrom:Nature Medicine (Vol. 27, Issue 1) Peer-Reviewed

  Jan. 20211,328 words Article 1540LThere has been a lot of hype around the applications of machine learning in medicine. But how is machine learning actually helping bench-to-bedside scientists and clinicians do their jobs? Author(s): Mike May 1...

• A neuroimaging biomarker for sustained experimental and clinical pain

  Authors:Jae-Joong Lee, Hong Ji Kim, Marta Ceko, Bo-yong Park, Soo Ahn Lee, Hyunjin Park, et al.From:Nature Medicine (Vol. 27, Issue 1) Peer-Reviewed

  Jan. 202114,090 words Report 1480LSustained pain is a major characteristic of clinical pain disorders, but it is difficult to assess in isolation from co-occurring cognitive and emotional features in patients. In this study, we developed a functional...

• Modeling human adaptive immune responses with tonsil organoids

  Authors:Lisa E. Wagar, Ameen Salahudeen, Christian M. Constantz, Ben S. Wendel, Michael M. Lyons, Vamsee Mallajosyula, et al.From:Nature Medicine (Vol. 27, Issue 1) Peer-Reviewed

  Jan. 202113,425 words Report 1580LMost of what we know about adaptive immunity has come from inbred mouse studies, using methods that are often difficult or impossible to confirm in humans. In addition, vaccine responses in mice are often poorly...

• Immune determinants of COVID-19 disease presentation and severity

  Author:Petter BrodinFrom:Nature Medicine (Vol. 27, Issue 1) Peer-Reviewed

  Jan. 20215,644 words Report 1590LCOVID-19, caused by SARS-CoV-2 infection, is mild to moderate in the majority of previously healthy individuals, but can cause life-threatening disease or persistent debilitating symptoms in some cases. The most...

• Patients could share virtual medical appointments for better access to telemedicine

  Authors:Kamalini Ramdas and Soumya SwaminathanFrom:Nature Medicine (Vol. 27, Issue 1) Peer-Reviewed

  Jan. 20211,382 words Article 1620LShared medical appointments, whereby patients with similar medical conditions consult their medical practitioner together, alleviate pressure on the health system and provide an instant support network for the patient....

• Wearable sensor data and self-reported symptoms for COVID-19 detection

  Authors:Giorgio Quer, Jennifer M. Radin, Matteo Gadaleta, Katie Baca-Motes, Lauren Ariniello, Edward Ramos, et al.From:Nature Medicine (Vol. 27, Issue 1) Peer-Reviewed

  Jan. 20214,569 words Report 1570LTraditional screening for COVID-19 typically includes survey questions about symptoms and travel history, as well as temperature measurements. Here, we explore whether personal sensor data collected over time may help...

• Indirect benefits are a crucial consideration when evaluating SARS-CoV-2 vaccine candidates

  Authors:Molly E. Gallagher, Andrew J. Sieben, Kristin N. Nelson, Alicia N. M. Kraay, Walter A. Orenstein, Ben Lopman, et al.From:Nature Medicine (Vol. 27, Issue 1) Peer-Reviewed

  Jan. 20211,097 words Letter to the editor 1630LAuthor(s): Molly E. Gallagher 1 , Andrew J. Sieben 2 , Kristin N. Nelson 3 , Alicia N. M. Kraay 3 , Walter A. Orenstein 4 5 , Ben Lopman 3 , Andreas Handel 6 , Katia Koelle 1 5 Author Affiliations: (1) Department...

• Automated screening of COVID-19 preprints: can we help authors to improve transparency and reproducibility?

  Authors:Tracey Weissgerber, Nico Riedel, Halil Kilicoglu, Cyril Labbe, Peter Eckmann, Gerben ter Riet, et al.From:Nature Medicine (Vol. 27, Issue 1) Peer-Reviewed

  Jan. 20211,294 words Letter to the editor 1470LAuthor(s): Tracey Weissgerber 1 2 , Nico Riedel 1 , Halil Kilicoglu 3 , Cyril Labbé 4 , Peter Eckmann 5 6 , Gerben ter Riet 7 8 , Jennifer Byrne 9 10 , Guillaume Cabanac 11 , Amanda Capes-Davis 12 , Bertrand Favier 13 ,...

• Brown adipose tissue is associated with cardiometabolic health

  Authors:Tobias Becher, Srikanth Palanisamy, Daniel J. Kramer, Mahmoud Eljalby, Sarah J. Marx, Andreas G. Wibmer, et al.From:Nature Medicine (Vol. 27, Issue 1) Peer-Reviewed

  Jan. 20217,913 words Report 1570LWhite fat stores excess energy, whereas brown and beige fat are thermogenic and dissipate energy as heat. Thermogenic adipose tissues markedly improve glucose and lipid homeostasis in mouse models, although the extent...

• Single-cell dissection of intratumoral heterogeneity and lineage diversity in metastatic gastric adenocarcinoma

  Authors:Ruiping Wang, Minghao Dang, Kazuto Harada, Guangchun Han, Fang Wang, Melissa Pool Pizzi, et al.From:Nature Medicine (Vol. 27, Issue 1) Peer-Reviewed

  Jan. 202115,356 words Report 1530LIntratumoral heterogeneity (ITH) is a fundamental property of cancer; however, the origins of ITH remain poorly understood. We performed single-cell transcriptome profiling of peritoneal carcinomatosis (PC) from 15...

• Liver metastases inhibit immunotherapy efficacy

  Authors:Katherine E. Lindblad and Amaia LujambioFrom:Nature Medicine (Vol. 27, Issue 1) Peer-Reviewed

  Jan. 20211,684 words Report 1660LLiver metastases lead to resistance to immunotherapy through the 'siphoning' of tumor antigen-specific CD8.sup.+ T cells into the liver, which results in a systemic 'immune desert' incapable of controlling tumor burden....

• A map of lung cell types.

  Author:Hannah StowerFrom:Nature Medicine (Vol. 27, Issue 1) Peer-Reviewed

  Jan. 2021112 words Brief article 1390LAuthor(s): Hannah Stower 1 Author Affiliations: (1) Nature Medicine, Nature 587, 619-625 (2020) Single-cell RNA sequencing of approximately 75,000 human lung cells from all lung compartments has allowed the...