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    Academic Journals

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• Author Correction: Multimodel preclinical platform predicts clinical response of melanoma to immunotherapy.

  Authors:Eva Pérez-Guijarro, Howard H. Yang, Romina E. Araya, Rajaa El Meskini, Helen T. Michael, Suman Kumar Vodnala, et al.From:Nature Medicine (Vol. 27, Issue 2) Peer-Reviewed

  Feb. 2021361 words Correction notice, B... 2210LA Correction to this paper has been published: https://doi.org/10.1038/s41591-021-01252-6. Author(s): Eva Pérez-Guijarro 1, Howard H. Yang 1, Romina E. Araya 2, Rajaa El Meskini 3, Helen T. Michael 1, Suman Kumar...

• What's new in clinical CRISPR?

  Author:Carrie ArnoldFrom:Nature Medicine (Vol. 27, Issue 2) Peer-Reviewed

  Feb. 20211,211 words Article 1370LIn the past year, there has been more CRISPR news than the awarding of the Nobel Prize in Chemistry to Jennifer Doudna and Emmanuelle Charpentier. Gene editing has continued its forward momentum in major ways, and...

• Author Correction: Reconstruction of the human blood-brain barrier in vitro reveals a pathogenic mechanism of APOE4 in pericytes.

  Authors:Joel W. Blanchard, Michael Bula, Jose Davila-Velderrain, Leyla Anne Akay, Lena Zhu, Alexander Frank, et al.From:Nature Medicine (Vol. 27, Issue 2) Peer-Reviewed

  Feb. 2021239 words Correction notice, B... 1590LA Correction to this paper has been published: https://doi.org/10.1038/s41591-021-01250-8. Author(s): Joel W. Blanchard 1 2, Michael Bula 1 2, Jose Davila-Velderrain 3 4, Leyla Anne Akay 1 2, Lena Zhu 1 2, Alexander...

• The limits of acceptable political influence over the FDA.

  Authors:Holly Fernandez Lynch, Steven Joffe, and Matthew S. McCoyFrom:Nature Medicine (Vol. 27, Issue 2) Peer-Reviewed

  Feb. 20211,787 words Letter to the editor 1640LAuthor(s): Holly Fernandez Lynch 1 , Steven Joffe 1 , Matthew S. McCoy 1 Author Affiliations: (1) Department of Medical Ethics and Health Policy, Perelman School of Medicine, University of Pennsylvania, Philadelphia,...

• Intratumoral heterogeneity in cancer progression and response to immunotherapy.

  Authors:Ilio Vitale, Efrat Shema, Sherene Loi, and Lorenzo GalluzziFrom:Nature Medicine (Vol. 27, Issue 2) Peer-Reviewed

  Feb. 202113,743 words Report 1740LMost (if not all) tumors emerge and progress under a strong evolutionary pressure imposed by trophic, metabolic, immunological, and therapeutic factors. The relative impact of these factors on tumor evolution changes...

• COVID-19 vaccines: acting on the evidence.

  From:Nature Medicine (Vol. 27, Issue 2) Peer-Reviewed

  Feb. 2021965 words Editorial 1670LDiverging from tested vaccination regimens without scientific evidence could undermine public confidence in vaccines against COVID-19 and the success of a global vaccination strategy to curtail the pandemic. Author...

• The gut microbiome modulates the protective association between a Mediterranean diet and cardiometabolic disease risk.

  Authors:Dong D. Wang, Long H. Nguyen, Yanping Li, Yan Yan, Wenjie Ma, Ehud Rinott, et al.From:Nature Medicine (Vol. 27, Issue 2) Peer-Reviewed

  Feb. 202112,820 words Report 1680LTo address how the microbiome might modify the interaction between diet and cardiometabolic health, we analyzed longitudinal microbiome data from 307 male participants in the Health Professionals Follow-Up Study,...

• Impact of carbohydrates, fat and energy density on energy intake.

  Author:R. James StubbsFrom:Nature Medicine (Vol. 27, Issue 2) Peer-Reviewed

  Feb. 20211,677 words Article 1650LPeople on low-fat, low-energy-density diets have lower ad libitum energy intake than that of those on high-fat, high-energy-density diets. Author(s): R. James Stubbs 1 Author Affiliations: (1) School of Psychology,...

• Effect of a plant-based, low-fat diet versus an animal-based, ketogenic diet on ad libitum energy intake.

  Authors:Kevin D. Hall, Juen Guo, Amber B. Courville, James Boring, Robert Brychta, Kong Y. Chen, et al.From:Nature Medicine (Vol. 27, Issue 2) Peer-Reviewed

  Feb. 202113,046 words Report 1620LThe carbohydrate-insulin model of obesity posits that high-carbohydrate diets lead to excess insulin secretion, thereby promoting fat accumulation and increasing energy intake. Thus, low-carbohydrate diets are predicted...

• The androgen receptor is a tumor suppressor in estrogen receptor-positive breast cancer.

  Authors:Theresa E. Hickey, Luke A. Selth, Kee Ming Chia, Geraldine Laven-Law, Heloisa H. Milioli, Daniel Roden, et al.From:Nature Medicine (Vol. 27, Issue 2) Peer-Reviewed

  Feb. 202118,235 words Report 1490LThe role of the androgen receptor (AR) in estrogen receptor (ER)-[alpha]-positive breast cancer is controversial, constraining implementation of AR-directed therapies. Using a diverse, clinically relevant panel of...

• Durvalumab compared to maintenance chemotherapy in metastatic breast cancer: the randomized phase II SAFIR02-BREAST IMMUNO trial.

  Authors:Thomas Bachelot, Thomas Filleron, Ivan Bieche, Monica Arnedos, Mario Campone, Florence Dalenc, et al.From:Nature Medicine (Vol. 27, Issue 2) Peer-Reviewed

  Feb. 20217,209 words Report 1270LThe impact of single-agent antibodies against programmed death-ligand 1 (PD-L1) as maintenance therapy is unknown in patients with metastatic breast cancer. The SAFIR02-BREAST IMMUNO substudy included patients with human...

• DECIDE-AI: new reporting guidelines to bridge the development-to-implementation gap in clinical artificial intelligence.

  Authors:Baptiste Vasey, David A. Clifton, Gary S. Collins, Alastair K. Denniston, Livia Faes, Bart F. Geerts, et al.From:Nature Medicine (Vol. 27, Issue 2) Peer-Reviewed

  Feb. 20211,131 words Letter to the editor 1680LAs an increasing number of clinical decision-support systems driven by artificial intelligence progress from development to implementation, better guidance on the reporting of human factors and early-stage clinical...

• Individual and community-level risk for COVID-19 mortality in the United States.

  Authors:Jin Jin, Neha Agarwala, Prosenjit Kundu, Benjamin Harvey, Yuqi Zhang, Eliza Wallace, et al.From:Nature Medicine (Vol. 27, Issue 2) Peer-Reviewed

  Feb. 202112,141 words Report 1660LReducing COVID-19 burden for populations will require equitable and effective risk-based allocations of scarce preventive resources, including vaccinations.sup.1. To aid in this effort, we developed a general population...

• Looking beyond COVID-19 vaccine phase 3 trials.

  Authors:Jerome H. Kim, Florian Marks, and John D. ClemensFrom:Nature Medicine (Vol. 27, Issue 2) Peer-Reviewed

  Feb. 20217,137 words Article 1580LAfter the recent announcement of COVID-19 vaccine efficacy in clinical trials by several manufacturers for protection against severe disease, a comprehensive post-efficacy strategy for the next steps to ensure...

• Robust breast cancer detection in mammography and digital breast tomosynthesis using an annotation-efficient deep learning approach.

  Authors:William Lotter, Abdul Rahman Diab, Bryan Haslam, Jiye G. Kim, Giorgia Grisot, Eric Wu, et al.From:Nature Medicine (Vol. 27, Issue 2) Peer-Reviewed

  Feb. 202112,314 words Report 1500LBreast cancer remains a global challenge, causing over 600,000 deaths in 2018 (ref. .sup.1). To achieve earlier cancer detection, health organizations worldwide recommend screening mammography, which is estimated to...

• Survival and biomarker analyses from the OpACIN-neo and OpACIN neoadjuvant immunotherapy trials in stage III melanoma.

  Authors:E. A. Rozeman, E. P. Hoefsmit, I. L. M. Reijers, R. P. M. Saw, J. M. Versluis, O. Krijgsman, et al.From:Nature Medicine (Vol. 27, Issue 2) Peer-Reviewed

  Feb. 20219,531 words Report 1480LNeoadjuvant ipilimumab plus nivolumab showed high pathologic response rates (pRRs) in patients with macroscopic stage III melanoma in the phase 1b OpACIN (NCT02437279) and phase 2 OpACIN-neo (NCT02977052)...

• The effects of tobacco control policies on global smoking prevalence.

  Authors:Luisa S. Flor, Marissa B. Reitsma, Vinay Gupta, Marie Ng, and Emmanuela GakidouFrom:Nature Medicine (Vol. 27, Issue 2) Peer-Reviewed

  Feb. 20217,182 words Report 1580LSubstantial global effort has been devoted to curtailing the tobacco epidemic over the past two decades, especially after the adoption of the Framework Convention on Tobacco Control.sup.1 by the World Health Organization...

• High-frequency neuromodulation improves obsessive-compulsive behavior.

  Authors:Shrey Grover, John A. Nguyen, Vighnesh Viswanathan, and Robert M. G. ReinhartFrom:Nature Medicine (Vol. 27, Issue 2) Peer-Reviewed

  Feb. 202111,067 words Report 1500LNearly one billion people worldwide suffer from obsessive-compulsive behaviors.sup.1,2, yet our mechanistic understanding of these behaviors is incomplete, and effective therapeutics are unavailable. An emerging...

• Phase 1/2 trial of SARS-CoV-2 vaccine ChAdOx1 nCoV-19 with a booster dose induces multifunctional antibody responses.

  Authors:Jordan R. Barrett, Sandra Belij-Rammerstorfer, Christina Dold, Katie J. Ewer, Pedro M. Folegatti, Ciaran Gilbride, et al.From:Nature Medicine (Vol. 27, Issue 2) Peer-Reviewed

  Feb. 202113,806 words Report 1470LMore than 190 vaccines are currently in development to prevent infection by the novel severe acute respiratory syndrome coronavirus 2. Animal studies suggest that while neutralizing antibodies against the viral spike...

• Author Correction: The effect of LRRK2 loss-of-function variants in humans.

  Authors:Nicola Whiffin, Irina M. Armean, Aaron Kleinman, Jamie L. Marshall, Eric V. Minikel, Julia K. Goodrich, et al.From:Nature Medicine (Vol. 27, Issue 2) Peer-Reviewed

  Feb. 2021436 words Correction notice, B... 1850LA Correction to this paper has been published: https://doi.org/10.1038/s41591-020-01185-6. Author(s): Nicola Whiffin 1 2 3, Irina M. Armean 3 4, Aaron Kleinman 5, Jamie L. Marshall 3, Eric V. Minikel 3, Julia K....