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From:Nature Medicine (Vol. 27, Issue 2) Peer-ReviewedA Correction to this paper has been published: https://doi.org/10.1038/s41591-021-01252-6. Author(s): Eva Pérez-Guijarro 1, Howard H. Yang 1, Romina E. Araya 2, Rajaa El Meskini 3, Helen T. Michael 1, Suman Kumar...
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From:Nature Medicine (Vol. 27, Issue 2) Peer-ReviewedIn the past year, there has been more CRISPR news than the awarding of the Nobel Prize in Chemistry to Jennifer Doudna and Emmanuelle Charpentier. Gene editing has continued its forward momentum in major ways, and...
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From:Nature Medicine (Vol. 27, Issue 2) Peer-ReviewedA Correction to this paper has been published: https://doi.org/10.1038/s41591-021-01250-8. Author(s): Joel W. Blanchard 1 2, Michael Bula 1 2, Jose Davila-Velderrain 3 4, Leyla Anne Akay 1 2, Lena Zhu 1 2, Alexander...
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From:Nature Medicine (Vol. 27, Issue 2) Peer-ReviewedAuthor(s): Holly Fernandez Lynch 1 , Steven Joffe 1 , Matthew S. McCoy 1 Author Affiliations: (1) Department of Medical Ethics and Health Policy, Perelman School of Medicine, University of Pennsylvania, Philadelphia,...
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From:Nature Medicine (Vol. 27, Issue 2) Peer-ReviewedMost (if not all) tumors emerge and progress under a strong evolutionary pressure imposed by trophic, metabolic, immunological, and therapeutic factors. The relative impact of these factors on tumor evolution changes...
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From:Nature Medicine (Vol. 27, Issue 2) Peer-ReviewedDiverging from tested vaccination regimens without scientific evidence could undermine public confidence in vaccines against COVID-19 and the success of a global vaccination strategy to curtail the pandemic. Author...
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From:Nature Medicine (Vol. 27, Issue 2) Peer-ReviewedTo address how the microbiome might modify the interaction between diet and cardiometabolic health, we analyzed longitudinal microbiome data from 307 male participants in the Health Professionals Follow-Up Study,...
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From:Nature Medicine (Vol. 27, Issue 2) Peer-ReviewedPeople on low-fat, low-energy-density diets have lower ad libitum energy intake than that of those on high-fat, high-energy-density diets. Author(s): R. James Stubbs 1 Author Affiliations: (1) School of Psychology,...
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From:Nature Medicine (Vol. 27, Issue 2) Peer-ReviewedThe carbohydrate-insulin model of obesity posits that high-carbohydrate diets lead to excess insulin secretion, thereby promoting fat accumulation and increasing energy intake. Thus, low-carbohydrate diets are predicted...
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From:Nature Medicine (Vol. 27, Issue 2) Peer-ReviewedThe role of the androgen receptor (AR) in estrogen receptor (ER)-[alpha]-positive breast cancer is controversial, constraining implementation of AR-directed therapies. Using a diverse, clinically relevant panel of...
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From:Nature Medicine (Vol. 27, Issue 2) Peer-ReviewedThe impact of single-agent antibodies against programmed death-ligand 1 (PD-L1) as maintenance therapy is unknown in patients with metastatic breast cancer. The SAFIR02-BREAST IMMUNO substudy included patients with human...
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From:Nature Medicine (Vol. 27, Issue 2) Peer-ReviewedAs an increasing number of clinical decision-support systems driven by artificial intelligence progress from development to implementation, better guidance on the reporting of human factors and early-stage clinical...
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From:Nature Medicine (Vol. 27, Issue 2) Peer-ReviewedReducing COVID-19 burden for populations will require equitable and effective risk-based allocations of scarce preventive resources, including vaccinations.sup.1. To aid in this effort, we developed a general population...
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From:Nature Medicine (Vol. 27, Issue 2) Peer-ReviewedAfter the recent announcement of COVID-19 vaccine efficacy in clinical trials by several manufacturers for protection against severe disease, a comprehensive post-efficacy strategy for the next steps to ensure...
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From:Nature Medicine (Vol. 27, Issue 2) Peer-ReviewedBreast cancer remains a global challenge, causing over 600,000 deaths in 2018 (ref. .sup.1). To achieve earlier cancer detection, health organizations worldwide recommend screening mammography, which is estimated to...
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From:Nature Medicine (Vol. 27, Issue 2) Peer-ReviewedNeoadjuvant ipilimumab plus nivolumab showed high pathologic response rates (pRRs) in patients with macroscopic stage III melanoma in the phase 1b OpACIN (NCT02437279) and phase 2 OpACIN-neo (NCT02977052)...
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From:Nature Medicine (Vol. 27, Issue 2) Peer-ReviewedSubstantial global effort has been devoted to curtailing the tobacco epidemic over the past two decades, especially after the adoption of the Framework Convention on Tobacco Control.sup.1 by the World Health Organization...
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From:Nature Medicine (Vol. 27, Issue 2) Peer-ReviewedNearly one billion people worldwide suffer from obsessive-compulsive behaviors.sup.1,2, yet our mechanistic understanding of these behaviors is incomplete, and effective therapeutics are unavailable. An emerging...
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From:Nature Medicine (Vol. 27, Issue 2) Peer-ReviewedMore than 190 vaccines are currently in development to prevent infection by the novel severe acute respiratory syndrome coronavirus 2. Animal studies suggest that while neutralizing antibodies against the viral spike...
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From:Nature Medicine (Vol. 27, Issue 2) Peer-ReviewedA Correction to this paper has been published: https://doi.org/10.1038/s41591-020-01185-6. Author(s): Nicola Whiffin 1 2 3, Irina M. Armean 3 4, Aaron Kleinman 5, Jamie L. Marshall 3, Eric V. Minikel 3, Julia K....