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    Academic Journals

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• A targeted antisense therapeutic approach for Hutchinson-Gilford progeria syndrome.

  Authors:Michael R. Erdos, Wayne A. Cabral, Urraca L. Tavarez, Kan Cao, Jelena Gvozdenovic-Jeremic, Narisu Narisu, et al.From:Nature Medicine (Vol. 27, Issue 3) Peer-Reviewed

  Mar. 20219,877 words Report 1570LHutchinson-Gilford progeria syndrome (HGPS) is a rare accelerated aging disorder characterized by premature death from myocardial infarction or stroke. It is caused by de novo single-nucleotide mutations in the LMNA gene...

• Sixteen novel lineages of SARS-CoV-2 in South Africa.

  Authors:Houriiyah Tegally, Eduan Wilkinson, Richard J. Lessells, Jennifer Giandhari, Sureshnee Pillay, Nokukhanya Msomi, et al.From:Nature Medicine (Vol. 27, Issue 3) Peer-Reviewed

  Mar. 20218,113 words Report 1570LThe first severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in South Africa was identified on 5 March 2020, and by 26 March the country was in full lockdown (Oxford stringency index of 90).sup.1....

• A dangerous measles future looms beyond the COVID-19 pandemic.

  Authors:David N. Durrheim, Jon K. Andrus, Shahina Tabassum, Hyam Bashour, David Githanga, and Günter PfaffFrom:Nature Medicine (Vol. 27, Issue 3) Peer-Reviewed

  Mar. 20211,166 words Letter to the editor 1500LAuthor(s): David N. Durrheim 1 , Jon K. Andrus 2 , Shahina Tabassum 3 , Hyam Bashour 4 , David Githanga 5 , Günter Pfaff 6 Author Affiliations: (1) University of Newcastle, Newcastle, Australia (2) University of...

• Beyond recruitment: good participatory practice enhances the impact of research in a pandemic.

  Authors:Barthalomew Wilson, Katharine Wright, Robert Taylor, and Elizabeth HiggsFrom:Nature Medicine (Vol. 27, Issue 3) Peer-Reviewed

  Mar. 20212,562 words Report 1420LIn a health emergency, clear, two-way communication between researchers and a broad spectrum of stakeholders is essential to establishing trust--a prerequisite for meaningful uptake of new treatments and vaccines....

• Author Correction: Implications of TP53 allelic state for genome stability, clinical presentation and outcomes in myelodysplastic syndromes.

  Authors:Elsa Bernard, Yasuhito Nannya, Robert P. Hasserjian, Sean M. Devlin, Heinz Tuechler, Juan S. Medina-Martinez, et al.From:Nature Medicine (Vol. 27, Issue 3) Peer-Reviewed

  Mar. 20211,114 words Correction notice 2570LA Correction to this paper has been published: https://doi.org/10.1038/s41591-021-01253-5. Author(s): Elsa Bernard 1 2 , Yasuhito Nannya 3 , Robert P. Hasserjian 4 , Sean M. Devlin 5 , Heinz Tuechler 6 , Juan S....

• Understanding life and death in Latin America.

  Authors:Fernando Lanas and Pamela SeronFrom:Nature Medicine (Vol. 27, Issue 3) Peer-Reviewed

  Mar. 20211,246 words Report 1510LAn analysis of life expectancy and cause of death in 363 Latin American cities unveils wide differences between cities in the same country, and sheds light on the socioeconomic factors that determine how long people live...

• Single-cell RNA sequencing: one step closer to the clinic.

  Authors:Romanos Sklavenitis-Pistofidis, Gad Getz, and Irene GhobrialFrom:Nature Medicine (Vol. 27, Issue 3) Peer-Reviewed

  Mar. 20211,302 words Article 1690LSingle-cell RNA-sequencing can help in the prediction of drug resistance in patients with multiple myeloma. Author(s): Romanos Sklavenitis-Pistofidis 1 2 , Gad Getz 2 3 , Irene Ghobrial 1 2 4 Author Affiliations:...

• Transcriptional mediators of treatment resistance in lethal prostate cancer.

  Authors:Meng Xiao He, Michael S. Cuoco, Jett Crowdis, Alice Bosma-Moody, Zhenwei Zhang, Kevin Bi, et al.From:Nature Medicine (Vol. 27, Issue 3) Peer-Reviewed

  Mar. 202111,228 words Report 1620LMetastatic castration-resistant prostate cancer is typically lethal, exhibiting intrinsic or acquired resistance to second-generation androgen-targeting therapies and minimal response to immune checkpoint...

• Overcoming complacency in the face of infectious disease.

  Author:Margaret Fu-chun Chan FungFrom:Nature Medicine (Vol. 27, Issue 3) Peer-Reviewed

  Mar. 2021898 words Report 1410LFormer WHO Director-General Margaret Chan has learned some tenets at the heart of resolving every global health crisis. However, in the COVID-19 pandemic, pervasive complacency in the face of this learning kills....

• A perfusable, multifunctional epicardial device improves cardiac function and tissue repair.

  Authors:Shixing Huang, Dong Lei, Qi Yang, Yang Yang, Chenyu Jiang, Hongpeng Shi, et al.From:Nature Medicine (Vol. 27, Issue 3) Peer-Reviewed

  Mar. 202115,722 words Report 1410LDespite advances in technologies for cardiac repair after myocardial infarction (MI), new integrated therapeutic approaches still need to be developed. In this study, we designed a perfusable, multifunctional epicardial...

• Personal neoantigen vaccines induce persistent memory T cell responses and epitope spreading in patients with melanoma.

  Authors:Zhuting Hu, Donna E. Leet, Rosa L. Allesøe, Giacomo Oliveira, Shuqiang Li, Adrienne M. Luoma, et al.From:Nature Medicine (Vol. 27, Issue 3) Peer-Reviewed

  Mar. 202115,634 words Report 1650LPersonal neoantigen vaccines have been envisioned as an effective approach to induce, amplify and diversify antitumor T cell responses. To define the long-term effects of such a vaccine, we evaluated the clinical outcome...

• Systematic screening identifies therapeutic antisense oligonucleotides for Hutchinson-Gilford progeria syndrome.

  Authors:Madaiah Puttaraju, Michaela Jackson, Stephanie Klein, Asaf Shilo, C. Frank Bennett, Leslie Gordon, et al.From:Nature Medicine (Vol. 27, Issue 3) Peer-Reviewed

  Mar. 20218,498 words Report 1590LHutchinson-Gilford progeria syndrome (HGPS) is a rare, invariably fatal childhood premature aging disorder caused by a pre-messenger RNA (mRNA) splicing defect in the LMNA gene. We used combined in vitro screening and in...

• Life expectancy and mortality in 363 cities of Latin America.

  Authors:Usama Bilal, Philipp Hessel, Carolina Perez-Ferrer, Yvonne L. Michael, Tania Alfaro, Janeth Tenorio-Mucha, et al.From:Nature Medicine (Vol. 27, Issue 3) Peer-Reviewed

  Mar. 202110,905 words Report 1610LThe concept of a so-called urban advantage in health ignores the possibility of heterogeneity in health outcomes across cities. Using a harmonized dataset from the SALURBAL project, we describe variability and predictors...

• Humoral signatures of protective and pathological SARS-CoV-2 infection in children.

  Authors:Yannic C. Bartsch, Chuangqi Wang, Tomer Zohar, Stephanie Fischinger, Caroline Atyeo, John S. Burke, et al.From:Nature Medicine (Vol. 27, Issue 3) Peer-Reviewed

  Mar. 20218,695 words Report 1650LThe severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic continues to spread relentlessly, associated with a high frequency of respiratory failure and mortality. Children experience largely asymptomatic...

• Preparing for the next pandemic.

  From:Nature Medicine (Vol. 27, Issue 3) Peer-Reviewed

  Mar. 20211,043 words Editorial 1540LThe COVID-19 pandemic has opened a window of opportunity for rethinking the way countries prepare for public-health crises. This window must not be wasted. Author Affiliations: A year has gone by since the World...

• Neoadjuvant nivolumab or nivolumab plus ipilimumab in operable non-small cell lung cancer: the phase 2 randomized NEOSTAR trial.

  Authors:Tina Cascone, William N. William, Jr., Annikka Weissferdt, Cheuk H. Leung, Heather Y. Lin, Apar Pataer, et al.From:Nature Medicine (Vol. 27, Issue 3) Peer-Reviewed

  Mar. 202115,858 words Report 1500LIpilimumab improves clinical outcomes when combined with nivolumab in metastatic non-small cell lung cancer (NSCLC), but its efficacy and impact on the immune microenvironment in operable NSCLC remain unclear. We report...

• Tracking the emergence of new SARS-CoV-2 variants in South Africa.

  Authors:Anise N. Happi, Chinedu A. Ugwu, and Christian T. HappiFrom:Nature Medicine (Vol. 27, Issue 3) Peer-Reviewed

  Mar. 20211,228 words Report 1590LA large genomic surveillance effort in South Africa produced 1,365 high-quality whole genomes of SARS-CoV-2; this has identified 16 new lineages of the virus that had not been identified in other countries. Author(s):...

• Tomorrow's biggest microbial threats.

  Author:Mike MayFrom:Nature Medicine (Vol. 27, Issue 3) Peer-Reviewed

  Mar. 20211,547 words Report 1490LAlthough many health experts around the world must stay focused on the ongoing viral pandemic caused by SARS-CoV-2, similar viruses and microbial organisms such as bacteria could create the next global killer. Experts...

• Developing therapeutic approaches for twenty-first-century emerging infectious viral diseases.

  Authors:Rita M. Meganck and Ralph S. BaricFrom:Nature Medicine (Vol. 27, Issue 3) Peer-Reviewed

  Mar. 20219,858 words Report 1510LThe twenty-first century has already recorded more than ten major epidemic or pandemic virus emergence events, including the ongoing and devastating coronavirus disease 2019 (COVID-19) pandemic. As viral disease...

• Author Correction: Sampling the host response to SARS-CoV-2 in hospitals under siege.

  Authors:Alexander W. Charney, Nicole W. Simons, Konstantinos Mouskas, Lauren Lepow, Esther Cheng, Jessica Le Berichel, et al.From:Nature Medicine (Vol. 27, Issue 3) Peer-Reviewed

  Mar. 2021793 words Correction notice 2510LA Correction to this paper has been published: https://doi.org/10.1038/s41591-021-01247-3. Author(s): Alexander W. Charney 1 , Nicole W. Simons 1 , Konstantinos Mouskas 1 , Lauren Lepow 1 , Esther Cheng 1 , Jessica Le...