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• Author Correction: Patients could share virtual medical appointments for better access to telemedicine.

  Authors:Kamalini Ramdas and Soumya SwaminathanFrom:Nature Medicine (Vol. 27, Issue 4) Peer-Reviewed

  Apr. 2021171 words Correction notice, B... A Correction to this paper has been published: https://doi.org/10.1038/s41591-021-01306-9. Author(s): Kamalini Ramdas 1, Soumya Swaminathan 2 Author Affiliations: (1) Management Science and Operations, London...

• Gene therapy needs a long-term approach.

  From:Nature Medicine (Vol. 27, Issue 4) Peer-Reviewed

  Apr. 20211,041 words Editorial 1480LGene-therapy trials are on the rise, but more needs to be done to understand the long-term risks associated with this type of treatment. Author Affiliations: On 16 February 2021, Bluebird Bio suspended phase 1/2 and...

• SARS-CoV-2 501Y.V2 escapes neutralization by South African COVID-19 donor plasma.

  Authors:Constantinos Kurt Wibmer, Frances Ayres, Tandile Hermanus, Mashudu Madzivhandila, Prudence Kgagudi, Brent Oosthuysen, et al.From:Nature Medicine (Vol. 27, Issue 4) Peer-Reviewed

  Apr. 20215,013 words Report 1650LSARS-CoV-2 501Y.V2 (B.1.351), a novel lineage of coronavirus causing COVID-19, contains substitutions in two immunodominant domains of the spike protein. Here, we show that pseudovirus expressing 501Y.V2 spike protein...

• Is presymptomatic ALS perivascular?

  Authors:Collin J. Kreple, Kathleen M. Schoch, and Timothy M. MillerFrom:Nature Medicine (Vol. 27, Issue 4) Peer-Reviewed

  Apr. 20211,231 words Article 1490LIncreased activity in perivascular fibroblasts could precede motor-neuron degeneration and be a predictor of shorter survival in amyotrophic lateral sclerosis. Author(s): Collin J. Kreple 1 , Kathleen M. Schoch 1 ,...

• Fetal cranial growth trajectories are associated with growth and neurodevelopment at 2 years of age: INTERBIO-21st Fetal Study.

  Authors:José Villar, Robert B. Gunier, Chrystelle O. O. Tshivuila-Matala, Stephen A. Rauch, Francois Nosten, Roseline Ochieng, et al.From:Nature Medicine (Vol. 27, Issue 4) Peer-Reviewed

  Apr. 202110,080 words Report 1540LMany observational studies and some randomized trials demonstrate how fetal growth can be influenced by environmental insults (for example, maternal infections).sup.1 and preventive interventions (for example,...

• Homozygous BCMA gene deletion in response to anti-BCMA CAR T cells in a patient with multiple myeloma.

  Authors:Matteo C. Da Vià, Oliver Dietrich, Marietta Truger, Panagiota Arampatzi, Johannes Duell, Anke Heidemeier, et al.From:Nature Medicine (Vol. 27, Issue 4) Peer-Reviewed

  Apr. 20215,545 words Clinical report 1550LB cell maturation antigen (BCMA) is a target for various immunotherapies and a biomarker for tumor load in multiple myeloma (MM). We report a case of irreversible BCMA loss in a patient with MM who was enrolled in the...

• The need for ethical guidance for the use of patient-reported outcomes in research and clinical practice.

  Authors:Samantha Cruz Rivera, Rebecca Mercieca-Bebber, Olalekan Lee Aiyegbusi, Jane Scott, Amanda Hunn, Conrad Fernandez, et al.From:Nature Medicine (Vol. 27, Issue 4) Peer-Reviewed

  Apr. 20211,153 words Letter to the editor 1710LAuthor(s): Samantha Cruz Rivera 1 2 , Rebecca Mercieca-Bebber 3 , Olalekan Lee Aiyegbusi 1 2 4 , Jane Scott 5 , Amanda Hunn 6 , Conrad Fernandez 7 , Jonathan Ives 8 , Carolyn Ells 9 , Gary Price 1 , Heather Draper 10 ,...

• Gene replacement of [alpha]-globin with [beta]-globin restores hemoglobin balance in [beta]-thalassemia-derived hematopoietic stem and progenitor cells.

  Authors:M. Kyle Cromer, Joab Camarena, Renata M. Martin, Benjamin J. Lesch, Christopher A. Vakulskas, Nicole M. Bode, et al.From:Nature Medicine (Vol. 27, Issue 4) Peer-Reviewed

  Apr. 202112,310 words Report 1550L[beta]-Thalassemia pathology is due not only to loss of [beta]-globin (HBB), but also to erythrotoxic accumulation and aggregation of the [beta]-globin-binding partner, [alpha]-globin (HBA1/2). Here we describe a...

• COVID-19 vaccination: the VOICE for patients with cancer.

  Authors:Astrid A. M. van der Veldt, Sjoukje F. Oosting, Anne-Marie C. Dingemans, Rudolf S. N. Fehrmann, Corine GeurtsvanKessel, Mathilde Jalving, et al.From:Nature Medicine (Vol. 27, Issue 4) Peer-Reviewed

  Apr. 20211,439 words Letter to the editor 1620LAuthor(s): Astrid A. M. van der Veldt 1 , Sjoukje F. Oosting 2 , Anne-Marie C. Dingemans 3 , Rudolf S. N. Fehrmann 2 , Corine GeurtsvanKessel 4 , Mathilde Jalving 2 , Guus F. Rimmelzwaan 5 , Pia Kvistborg 6 , Christian...

• Integrative microbiomics in bronchiectasis exacerbations.

  Authors:Micheál Mac Aogáin, Jayanth Kumar Narayana, Pei Yee Tiew, Nur A'tikah Binte Mohamed Ali, Valerie Fei Lee Yong, Tavleen Kaur Jaggi, et al.From:Nature Medicine (Vol. 27, Issue 4) Peer-Reviewed

  Apr. 202115,595 words Report 1650LBronchiectasis, a progressive chronic airway disease, is characterized by microbial colonization and infection. We present an approach to the multi-biome that integrates bacterial, viral and fungal communities in...

• Post-acute COVID-19 syndrome.

  Authors:Ani Nalbandian, Kartik Sehgal, Aakriti Gupta, Mahesh V. Madhavan, Claire McGroder, Jacob S. Stevens, et al.From:Nature Medicine (Vol. 27, Issue 4) Peer-Reviewed

  Apr. 202114,911 words Report 1630LSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the pathogen responsible for the coronavirus disease 2019 (COVID-19) pandemic, which has resulted in global healthcare crises and strained health resources....

• Immunotherapy and targeted-therapy combinations mark a new era of kidney cancer treatment.

  Authors:Tian Zhang and Daniel J. GeorgeFrom:Nature Medicine (Vol. 27, Issue 4) Peer-Reviewed

  Apr. 20211,777 words Article 1450LResults from the latest phase 3 clinical trial testing combinations of immunotherapy and tyrosine-kinase inhibitors for advanced kidney cancer improve standard first-line treatment options for patients. Author(s): Tian...

• Resistance of SARS-CoV-2 variants to neutralization by monoclonal and serum-derived polyclonal antibodies.

  Authors:Rita E. Chen, Xianwen Zhang, James Brett Case, Emma S. Winkler, Yang Liu, Laura A. VanBlargan, et al.From:Nature Medicine (Vol. 27, Issue 4) Peer-Reviewed

  Apr. 202110,568 words Report 1590LSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the global COVID-19 pandemic. Rapidly spreading SARS-CoV-2 variants may jeopardize newly introduced antibody and vaccine countermeasures. Here,...

• Changing climate and the COVID-19 pandemic: more than just heads or tails.

  Authors:Xavier Rodó, Adrià San-José, Karin Kirchgatter, and Leonardo LópezFrom:Nature Medicine (Vol. 27, Issue 4) Peer-Reviewed

  Apr. 20213,149 words Article 1610LClimate change can both facilitate zoonotic spillovers and have an effect on transmission chains. These effects, alongside human behavior and awareness, need to be integrated in pandemic forecasting models. Author(s):...

• "I had to be with bodyguards with guns"--attacks on scientists during the pandemic.

  Author:Anita MakriFrom:Nature Medicine (Vol. 27, Issue 4) Peer-Reviewed

  Apr. 20213,054 words Article 1060LPublic-health researchers are more visible than ever before. But for some, this has led to abuse and attacks that threaten to silence them. Author(s): Anita Makri 1 Author Affiliations: (1) Science journalist,...

• How medical AI devices are evaluated: limitations and recommendations from an analysis of FDA approvals.

  Authors:Eric Wu, Kevin Wu, Roxana Daneshjou, David Ouyang, Daniel E. Ho, and James ZouFrom:Nature Medicine (Vol. 27, Issue 4) Peer-Reviewed

  Apr. 20212,052 words Article 1490LA comprehensive overview of medical AI devices approved by the US Food and Drug Administration sheds new light on limitations of the evaluation process that can mask vulnerabilities of devices when they are deployed on...

• Malaria is a cause of iron deficiency in African children.

  Authors:John Muthii Muriuki, Alexander J. Mentzer, Ruth Mitchell, Emily L. Webb, Anthony O. Etyang, Catherine Kyobutungi, et al.From:Nature Medicine (Vol. 27, Issue 4) Peer-Reviewed

  Apr. 202110,715 words Report 1490LMalaria and iron deficiency (ID) are common and interrelated public health problems in African children. Observational data suggest that interrupting malaria transmission reduces the prevalence of ID.sup.1. To test the...

• Integration of genomic sequencing into the response to the Ebola virus outbreak in Nord Kivu, Democratic Republic of the Congo.

  Authors:Eddy Kinganda-Lusamaki, Allison Black, Daniel B. Mukadi, James Hadfield, Placide Mbala-Kingebeni, Catherine B. Pratt, et al.From:Nature Medicine (Vol. 27, Issue 4) Peer-Reviewed

  Apr. 20216,713 words Report 1540LOn 1 August 2018, the Democratic Republic of the Congo (DRC) declared its tenth Ebola virus disease (EVD) outbreak. To aid the epidemiologic response, the Institut National de Recherche Biomédicale (INRB) implemented an...

• The STEP 1 trial for weight loss: a step change in treating obesity?

  Author:Amanda I. AdlerFrom:Nature Medicine (Vol. 27, Issue 4) Peer-Reviewed

  Apr. 20211,557 words Article 1460LA new trial shows that adding the glucagon-like peptide 1 analog semaglutide to diet and exercise leads to weight loss. Author(s): Amanda I. Adler 1 Author Affiliations: (1) Oxford Centre for Diabetes Endocrinology...

• Making treatment decisions in a void of information.

  Author:Jesús Rodríguez-BañoFrom:Nature Medicine (Vol. 27, Issue 4) Peer-Reviewed

  Apr. 2021930 words Article 1250LRevisiting the challenges of the beginning of the COVID-19 pandemic, when doctors and patients had to make treatment decisions without the support of scientific evidence, can provide valuable clues on how to prepare for...