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From:Nature Medicine (Vol. 27, Issue 4) Peer-ReviewedA Correction to this paper has been published: https://doi.org/10.1038/s41591-021-01306-9. Author(s): Kamalini Ramdas 1, Soumya Swaminathan 2 Author Affiliations: (1) Management Science and Operations, London...
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From:Nature Medicine (Vol. 27, Issue 4) Peer-ReviewedGene-therapy trials are on the rise, but more needs to be done to understand the long-term risks associated with this type of treatment. Author Affiliations: On 16 February 2021, Bluebird Bio suspended phase 1/2 and...
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From:Nature Medicine (Vol. 27, Issue 4) Peer-ReviewedSARS-CoV-2 501Y.V2 (B.1.351), a novel lineage of coronavirus causing COVID-19, contains substitutions in two immunodominant domains of the spike protein. Here, we show that pseudovirus expressing 501Y.V2 spike protein...
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From:Nature Medicine (Vol. 27, Issue 4) Peer-ReviewedIncreased activity in perivascular fibroblasts could precede motor-neuron degeneration and be a predictor of shorter survival in amyotrophic lateral sclerosis. Author(s): Collin J. Kreple 1 , Kathleen M. Schoch 1 ,...
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From:Nature Medicine (Vol. 27, Issue 4) Peer-ReviewedMany observational studies and some randomized trials demonstrate how fetal growth can be influenced by environmental insults (for example, maternal infections).sup.1 and preventive interventions (for example,...
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From:Nature Medicine (Vol. 27, Issue 4) Peer-ReviewedB cell maturation antigen (BCMA) is a target for various immunotherapies and a biomarker for tumor load in multiple myeloma (MM). We report a case of irreversible BCMA loss in a patient with MM who was enrolled in the...
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From:Nature Medicine (Vol. 27, Issue 4) Peer-ReviewedAuthor(s): Samantha Cruz Rivera 1 2 , Rebecca Mercieca-Bebber 3 , Olalekan Lee Aiyegbusi 1 2 4 , Jane Scott 5 , Amanda Hunn 6 , Conrad Fernandez 7 , Jonathan Ives 8 , Carolyn Ells 9 , Gary Price 1 , Heather Draper 10 ,...
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From:Nature Medicine (Vol. 27, Issue 4) Peer-Reviewed[beta]-Thalassemia pathology is due not only to loss of [beta]-globin (HBB), but also to erythrotoxic accumulation and aggregation of the [beta]-globin-binding partner, [alpha]-globin (HBA1/2). Here we describe a...
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From:Nature Medicine (Vol. 27, Issue 4) Peer-ReviewedAuthor(s): Astrid A. M. van der Veldt 1 , Sjoukje F. Oosting 2 , Anne-Marie C. Dingemans 3 , Rudolf S. N. Fehrmann 2 , Corine GeurtsvanKessel 4 , Mathilde Jalving 2 , Guus F. Rimmelzwaan 5 , Pia Kvistborg 6 , Christian...
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From:Nature Medicine (Vol. 27, Issue 4) Peer-ReviewedBronchiectasis, a progressive chronic airway disease, is characterized by microbial colonization and infection. We present an approach to the multi-biome that integrates bacterial, viral and fungal communities in...
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From:Nature Medicine (Vol. 27, Issue 4) Peer-ReviewedSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the pathogen responsible for the coronavirus disease 2019 (COVID-19) pandemic, which has resulted in global healthcare crises and strained health resources....
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From:Nature Medicine (Vol. 27, Issue 4) Peer-ReviewedResults from the latest phase 3 clinical trial testing combinations of immunotherapy and tyrosine-kinase inhibitors for advanced kidney cancer improve standard first-line treatment options for patients. Author(s): Tian...
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From:Nature Medicine (Vol. 27, Issue 4) Peer-ReviewedSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the global COVID-19 pandemic. Rapidly spreading SARS-CoV-2 variants may jeopardize newly introduced antibody and vaccine countermeasures. Here,...
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From:Nature Medicine (Vol. 27, Issue 4) Peer-ReviewedClimate change can both facilitate zoonotic spillovers and have an effect on transmission chains. These effects, alongside human behavior and awareness, need to be integrated in pandemic forecasting models. Author(s):...
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From:Nature Medicine (Vol. 27, Issue 4) Peer-ReviewedPublic-health researchers are more visible than ever before. But for some, this has led to abuse and attacks that threaten to silence them. Author(s): Anita Makri 1 Author Affiliations: (1) Science journalist,...
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From:Nature Medicine (Vol. 27, Issue 4) Peer-ReviewedA comprehensive overview of medical AI devices approved by the US Food and Drug Administration sheds new light on limitations of the evaluation process that can mask vulnerabilities of devices when they are deployed on...
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From:Nature Medicine (Vol. 27, Issue 4) Peer-ReviewedMalaria and iron deficiency (ID) are common and interrelated public health problems in African children. Observational data suggest that interrupting malaria transmission reduces the prevalence of ID.sup.1. To test the...
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From:Nature Medicine (Vol. 27, Issue 4) Peer-ReviewedOn 1 August 2018, the Democratic Republic of the Congo (DRC) declared its tenth Ebola virus disease (EVD) outbreak. To aid the epidemiologic response, the Institut National de Recherche Biomédicale (INRB) implemented an...
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From:Nature Medicine (Vol. 27, Issue 4) Peer-ReviewedA new trial shows that adding the glucagon-like peptide 1 analog semaglutide to diet and exercise leads to weight loss. Author(s): Amanda I. Adler 1 Author Affiliations: (1) Oxford Centre for Diabetes Endocrinology...
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From:Nature Medicine (Vol. 27, Issue 4) Peer-ReviewedRevisiting the challenges of the beginning of the COVID-19 pandemic, when doctors and patients had to make treatment decisions without the support of scientific evidence, can provide valuable clues on how to prepare for...