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From:Nature Medicine (Vol. 27, Issue 5) Peer-ReviewedBlack scientists have been historically underrepresented in academia and science. A 2018 study of the National Center for Education Statistics found that only 6% of faculty in the USA were Black. Systemic racism and...
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From:Nature Medicine (Vol. 27, Issue 5) Peer-ReviewedHuman microbiome science has advanced rapidly and reached a scale at which basic biology, clinical translation and population health are increasingly integrated. It is thus now possible for public health researchers,...
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From:Nature Medicine (Vol. 27, Issue 5) Peer-ReviewedCongenital heart disease (CHD) is the most common birth defect. Fetal screening ultrasound provides five views of the heart that together can detect 90% of complex CHD, but in practice, sensitivity is as low as 30%....
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From:Nature Medicine (Vol. 27, Issue 5) Peer-ReviewedWhile CD19-directed chimeric antigen receptor (CAR) T cells can induce remission in patients with B cell acute lymphoblastic leukemia (ALL), a large subset relapse with CD19.sup.- disease. Like CD19, CD22 is broadly...
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From:Nature Medicine (Vol. 27, Issue 5) Peer-ReviewedLeber congenital amaurosis due to CEP290 ciliopathy is being explored by treatment with the antisense oligonucleotide (AON) sepofarsen. One patient who was part of a larger cohort (ClinicalTrials.gov NCT03140969) was...
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From:Nature Medicine (Vol. 27, Issue 5) Peer-ReviewedNew advances in machine learning could facilitate and reduce disparities in the prenatal diagnosis of congenital health disease, the most common and lethal birth defect. Author(s): Shaine A. Morris 1 , Keila N. Lopez 1...
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From:Nature Medicine (Vol. 27, Issue 5) Peer-ReviewedAlzheimer's disease (AD) is characterized by the spread of tau pathology throughout the cerebral cortex. This spreading pattern was thought to be fairly consistent across individuals, although recent work has...
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From:Nature Medicine (Vol. 27, Issue 5) Peer-ReviewedSARS-CoV-2 can escape natural immune responses, but can the virus evade monoclonal antibodies and vaccine-mediated immunity? Author(s): Emanuele Andreano 1 , Rino Rappuoli 1 2 Author Affiliations: (1) Monoclonal...
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From:Nature Medicine (Vol. 27, Issue 5) Peer-ReviewedAuthor(s): Ngozi A. Erondu 1 2 , Ifeyinwa Aniebo 1 3 4 , Catherine Kyobutungi 5 , Janet Midega 1 6 , Emelda Okiro 7 , Fredros Okumu 1 8 Author Affiliations: (1) Aspen Institute, Washington, USA (2) O'Neill...
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From:Nature Medicine (Vol. 27, Issue 5) Peer-ReviewedImmune-checkpoint blockade (ICB) combined with neoadjuvant chemotherapy improves pathological complete response in breast cancer. To understand why only a subset of tumors respond to ICB, patients with hormone...
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From:Nature Medicine (Vol. 27, Issue 5) Peer-ReviewedUnexpected clinical results unearth a new facet in CAR design that could facilitate the development of more-effective CAR T cell therapies. Author(s): Kristen Hege 1 2 Author Affiliations: (1) Early Clinical...
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From:Nature Medicine (Vol. 27, Issue 5) Peer-ReviewedAuthor(s): Anna Mia Ekström 1 , Camilla Berggren 2 , Göran Tomson 2 3 , Lawrence O. Gostin 4 , Peter Friberg 2 5 , Ole Petter Ottersen 3 Author Affiliations: (1) Department of Global Public Health, Karolinska...
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From:Nature Medicine (Vol. 27, Issue 5) Peer-ReviewedInvestment in research and programs to discover and apply the principles that underpin sustained behavior change is needed to address the continuing threat from COVID-19 and future pandemics and will require...
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From:Nature Medicine (Vol. 27, Issue 5) Peer-ReviewedEnsuring access to vaccines against COVID-19 for refugee and displaced populations and addressing health inequities are vital for an effective pandemic response. Author(s): Monette Zard 1 , Ling San Lau 1 , Diana M....
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From:Nature Medicine (Vol. 27, Issue 5) Peer-ReviewedAuthor(s): Elsa Bernard 1 2 , Yasuhito Nannya 3 , Robert P. Hasserjian 4 , Sean M. Devlin 5 , Heinz Tuechler 6 , Juan S. Medina-Martinez 1 2 , Tetsuichi Yoshizato 3 , Yusuke Shiozawa 3 , Ryunosuke Saiki 3 , Luca...
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From:Nature Medicine (Vol. 27, Issue 5) Peer-ReviewedCystic fibrosis (CF) is a lethal autosomal recessive disorder that afflicts more than 70,000 people. People with CF experience multi-organ dysfunction resulting from aberrant electrolyte transport across polarized...
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From:Nature Medicine (Vol. 27, Issue 5) Peer-ReviewedSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) B.1.1.7 and B.1.351 variants were first identified in the United Kingdom and South Africa, respectively, and have since spread to many countries. These...
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From:Nature Medicine (Vol. 27, Issue 5) Peer-ReviewedDeep learning methods have been shown to achieve excellent performance on diagnostic tasks, but how to optimally combine them with expert knowledge and existing clinical decision pathways is still an open challenge. This...
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From:Nature Medicine (Vol. 27, Issue 5) Peer-ReviewedEnhancing population diversity in genetic databases and evaluating genetic scores in conjunction with other disease factors will be needed to ensure a more equitable impact of precision medicine. Author Affiliations:...
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From:Nature Medicine (Vol. 27, Issue 5) Peer-ReviewedWe have conducted a pragmatic clinical trial aimed to assess whether an electrocardiogram (ECG)-based, artificial intelligence (AI)-powered clinical decision support tool enables early diagnosis of low ejection fraction...