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    Academic Journals

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• Being fair to participants in placebo-controlled COVID-19 vaccine trials.

  Authors:Rafael Dal-Ré, Walter Orenstein, and Arthur L. CaplanFrom:Nature Medicine (Vol. 27, Issue 6) Peer-Reviewed

  June 2021960 words Letter to the editor 1830LAuthor(s): Rafael Dal-Ré 1 , Walter Orenstein 2 3 , Arthur L. Caplan 4 Author Affiliations: (1) Epidemiology Unit, Health Research Institute-Fundación Jiménez Díaz University Hospital, Universidad Autónoma de Madrid,...

• Author Correction: Emergence and clonal expansion of in vitro artemisinin-resistant Plasmodium falciparum kelch13 R561H mutant parasites in Rwanda.

  Authors:Aline Uwimana, Eric Legrand, Barbara H. Stokes, Jean-Louis Mangala Ndikumana, Marian Warsame, Noella Umulisa, et al.From:Nature Medicine (Vol. 27, Issue 6) Peer-Reviewed

  June 2021395 words Correction notice, B... 1690LAuthor(s): Aline Uwimana 1, Eric Legrand 2, Barbara H. Stokes 3, Jean-Louis Mangala Ndikumana 1, Marian Warsame 4, Noella Umulisa 5 6, Daniel Ngamije 7, Tharcisse Munyaneza 8, Jean-Baptiste Mazarati 8, Kaendi Munguti 9,...

• After COVID-19 successes, researchers push to develop mRNA vaccines for other diseases.

  Author:Mike MayFrom:Nature Medicine (Vol. 27, Issue 6) Peer-Reviewed

  June 20212,647 words Article 1290LmRNA vaccines are now in the limelight as a key tool for tackling COVID-19, but the technology was originally developed for other diseases, such as cancer, that researchers are now hoping to treat. Author(s): Mike May...

• The vicious and virtuous circles of clonal hematopoiesis.

  Authors:Nili Furer, Nathali Kaushansky, and Liran I. ShlushFrom:Nature Medicine (Vol. 27, Issue 6) Peer-Reviewed

  June 20211,242 words Article 1590LClonal hematopoiesis can exist as both a driver and a consequence of inflammatory dysregulation. Author(s): Nili Furer 1 , Nathali Kaushansky 1 , Liran I. Shlush 1 Author Affiliations: (1) Department of Immunology,...

• XCR1.sup.+ type 1 conventional dendritic cells drive liver pathology in non-alcoholic steatohepatitis.

  Authors:Aleksandra Deczkowska, Eyal David, Pierluigi Ramadori, Dominik Pfister, Michael Safran, Baoguo At the, et al.From:Nature Medicine (Vol. 27, Issue 6) Peer-Reviewed

  June 202114,841 words Report 1760LNon-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are prevalent liver conditions that underlie the development of life-threatening cirrhosis, liver failure and liver cancer. Chronic...

• Improving patient care through the development of a 5G-powered smart hospital.

  Authors:Guowei Li, Wanmin Lian, Hongying Qu, Ziyi Li, Qiru Zhou, and Junzhang TianFrom:Nature Medicine (Vol. 27, Issue 6) Peer-Reviewed

  June 20211,109 words Letter to the editor 1580LAuthor(s): Guowei Li 1 2 , Wanmin Lian 3 , Hongying Qu 1 , Ziyi Li 1 , Qiru Zhou 4 , Junzhang Tian 5 Author Affiliations: (1) Center for Clinical Epidemiology and Methodology, Guangdong Second Provincial General...

• MDMA-assisted therapy for severe PTSD: a randomized, double-blind, placebo-controlled phase 3 study.

  Authors:Jennifer M. Mitchell, Michael Bogenschutz, Alia Lilienstein, Charlotte Harrison, Sarah Kleiman, Kelly Parker-Guilbert, et al.From:Nature Medicine (Vol. 27, Issue 6) Peer-Reviewed

  June 202110,046 words Report 1620LPost-traumatic stress disorder (PTSD) presents a major public health problem for which currently available treatments are modestly effective. We report the findings of a randomized, double-blind, placebo-controlled,...

• Author Correction: T cell and antibody responses induced by a single dose of ChAdOx1 nCoV-19 (AZD1222) vaccine in a phase 1/2 clinical trial.

  Authors:Katie J. Ewer, Jordan R. Barrett, Sandra Belij-Rammerstorfer, Hannah Sharpe, Rebecca Makinson, Richard Morter, et al.From:Nature Medicine (Vol. 27, Issue 6) Peer-Reviewed

  June 20211,349 words Correction notice 3330LAuthor(s): Katie J. Ewer 1 , Jordan R. Barrett 1 , Sandra Belij-Rammerstorfer 1 , Hannah Sharpe 1 , Rebecca Makinson 1 , Richard Morter 1 , Amy Flaxman 1 , Daniel Wright 1 , Duncan Bellamy 1 , Mustapha Bittaye 1 ,...

• Danuglipron (PF-06882961) in type 2 diabetes: a randomized, placebo-controlled, multiple ascending-dose phase 1 trial.

  Authors:Aditi R. Saxena, Donal N. Gorman, Ryan M. Esquejo, Arthur Bergman, Kristin Chidsey, Clare Buckeridge, et al.From:Nature Medicine (Vol. 27, Issue 6) Peer-Reviewed

  June 202113,449 words Report 1450LAgonism of the glucagon-like peptide-1 receptor (GLP-1R) results in glycemic lowering and body weight loss and is a therapeutic strategy to treat type 2 diabetes (T2D) and obesity. We developed danuglipron (PF-06882961),...

• Clinical integration of machine learning for curative-intent radiation treatment of patients with prostate cancer.

  Authors:Chris McIntosh, Leigh Conroy, Michael C. Tjong, Tim Craig, Andrew Bayley, Charles Catton, et al.From:Nature Medicine (Vol. 27, Issue 6) Peer-Reviewed

  June 202110,427 words Report 1680LMachine learning (ML) holds great promise for impacting healthcare delivery; however, to date most methods are tested in 'simulated' environments that cannot recapitulate factors influencing real-world clinical practice....

• Author Correction: Attributes and predictors of long COVID.

  Authors:Carole H. Sudre, Benjamin Murray, Thomas Varsavsky, Mark S. Graham, Rose S. Penfold, Ruth C. Bowyer, et al.From:Nature Medicine (Vol. 27, Issue 6) Peer-Reviewed

  June 2021410 words Correction notice, B... 2150LAuthor(s): Carole H. Sudre 1 2 3, Benjamin Murray 1, Thomas Varsavsky 1, Mark S. Graham 1, Rose S. Penfold 4, Ruth C. Bowyer 5, Joan Capdevila Pujol 5, Kerstin Klaser 1, Michela Antonelli 1, Liane S. Canas 1, Erika...

• Biomarkers for neurodegenerative diseases.

  Author:Oskar HanssonFrom:Nature Medicine (Vol. 27, Issue 6) Peer-Reviewed

  June 202110,638 words Report 1570LBiomarkers for neurodegenerative diseases are needed to improve the diagnostic workup in the clinic but also to facilitate the development and monitoring of effective disease-modifying therapies. Positron emission...

• Health systems resilience in managing the COVID-19 pandemic: lessons from 28 countries.

  Authors:Victoria Haldane, Chuan De Foo, Salma M. Abdalla, Anne-Sophie Jung, Melisa Tan, Shishi Wu, et al.From:Nature Medicine (Vol. 27, Issue 6) Peer-Reviewed

  June 202116,679 words Report 1560LHealth systems resilience is key to learning lessons from country responses to crises such as coronavirus disease 2019 (COVID-19). In this perspective, we review COVID-19 responses in 28 countries using a new health...

• Phenotypic signatures in clinical data enable systematic identification of patients for genetic testing.

  Authors:Theodore J. Morley, Lide Han, Victor M. Castro, Jonathan Morra, Roy H. Perlis, Nancy J. Cox, et al.From:Nature Medicine (Vol. 27, Issue 6) Peer-Reviewed

  June 20218,736 words Report 1560LAround 5% of the population is affected by a rare genetic disease, yet most endure years of uncertainty before receiving a genetic test. A common feature of genetic diseases is the presence of multiple rare phenotypes...

• Antibody responses to the BNT162b2 mRNA vaccine in individuals previously infected with SARS-CoV-2.

  Authors:Joseph E. Ebinger, Justyna Fert-Bober, Ignat Printsev, Min Wu, Nancy Sun, John C. Prostko, et al.From:Nature Medicine (Vol. 27, Issue 6) Peer-Reviewed

  June 20214,580 words Report 1640LIn a cohort of BNT162b2 (Pfizer-BioNTech) mRNA vaccine recipients (n = 1,090), we observed that spike-specific IgG antibody levels and ACE2 antibody binding inhibition responses elicited by a single vaccine dose in...

• HIV is associated with an increased risk of age-related clonal hematopoiesis among older adults.

  Authors:Nila J. Dharan, Paul Yeh, Mark Bloch, Miriam M. Yeung, David Baker, Jerick Guinto, et al.From:Nature Medicine (Vol. 27, Issue 6) Peer-Reviewed

  June 20216,613 words Report 1550LPeople with human immunodeficiency virus (HIV) have higher rates of certain comorbidities, particularly cardiovascular disease and cancer, than people without HIV.sup.1-5. In view of observations that somatic mutations...

• Safety and immunogenicity of the SARS-CoV-2 BNT162b1 mRNA vaccine in younger and older Chinese adults: a randomized, placebo-controlled, double-blind phase 1 study.

  Authors:Jingxin Li, Aimin Hui, Xiang Zhang, Yumei Yang, Rong Tang, Huayue Ye, et al.From:Nature Medicine (Vol. 27, Issue 6) Peer-Reviewed

  June 202110,135 words Report 1650LAn effective vaccine is needed to end the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. Here, we assess the preliminary safety, tolerability and immunogenicity data from an ongoing single-center...

• The world needs an intergovernmental panel on pandemic risk.

  Authors:Ben Oppenheim, Kaysie Brown, and Ron WaldmanFrom:Nature Medicine (Vol. 27, Issue 6) Peer-Reviewed

  June 2021890 words Letter to the editor 1240LAuthor(s): Ben Oppenheim 1 2 , Kaysie Brown 3 , Ron Waldman 4 5 Author Affiliations: (1) Metabiota, San Francisco, USA (2) Center on International Cooperation, New York University, New York, USA (3) United...

• One Health approaches require community engagement, education, and international collaborations--a lesson from Rwanda.

  Authors:Phaedra Henley, Gloria Igihozo, and Laura WottonFrom:Nature Medicine (Vol. 27, Issue 6) Peer-Reviewed

  June 20211,135 words Report 1630LOne Health approaches recognize the links between the environment, animals, and human disease, but these approaches are successful only with bottom-up community engagement, education, and international collaborations....

• Hematopoietic mosaic chromosomal alterations increase the risk for diverse types of infection.

  Authors:Seyedeh M. Zekavat, Shu-Hong Lin, Alexander G. Bick, Aoxing Liu, Kaavya Paruchuri, Chen Wang, et al.From:Nature Medicine (Vol. 27, Issue 6) Peer-Reviewed

  June 202111,719 words Report 1550LAge is the dominant risk factor for infectious diseases, but the mechanisms linking age to infectious disease risk are incompletely understood. Age-related mosaic chromosomal alterations (mCAs) detected from genotyping...