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From:Nature Medicine (Vol. 27, Issue 6) Peer-ReviewedAuthor(s): Rafael Dal-Ré 1 , Walter Orenstein 2 3 , Arthur L. Caplan 4 Author Affiliations: (1) Epidemiology Unit, Health Research Institute-Fundación Jiménez Díaz University Hospital, Universidad Autónoma de Madrid,...
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From:Nature Medicine (Vol. 27, Issue 6) Peer-ReviewedAuthor(s): Aline Uwimana 1, Eric Legrand 2, Barbara H. Stokes 3, Jean-Louis Mangala Ndikumana 1, Marian Warsame 4, Noella Umulisa 5 6, Daniel Ngamije 7, Tharcisse Munyaneza 8, Jean-Baptiste Mazarati 8, Kaendi Munguti 9,...
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From:Nature Medicine (Vol. 27, Issue 6) Peer-ReviewedmRNA vaccines are now in the limelight as a key tool for tackling COVID-19, but the technology was originally developed for other diseases, such as cancer, that researchers are now hoping to treat. Author(s): Mike May...
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From:Nature Medicine (Vol. 27, Issue 6) Peer-ReviewedClonal hematopoiesis can exist as both a driver and a consequence of inflammatory dysregulation. Author(s): Nili Furer 1 , Nathali Kaushansky 1 , Liran I. Shlush 1 Author Affiliations: (1) Department of Immunology,...
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From:Nature Medicine (Vol. 27, Issue 6) Peer-ReviewedNon-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are prevalent liver conditions that underlie the development of life-threatening cirrhosis, liver failure and liver cancer. Chronic...
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From:Nature Medicine (Vol. 27, Issue 6) Peer-ReviewedAuthor(s): Guowei Li 1 2 , Wanmin Lian 3 , Hongying Qu 1 , Ziyi Li 1 , Qiru Zhou 4 , Junzhang Tian 5 Author Affiliations: (1) Center for Clinical Epidemiology and Methodology, Guangdong Second Provincial General...
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From:Nature Medicine (Vol. 27, Issue 6) Peer-Reviewed
MDMA-assisted therapy for severe PTSD: a randomized, double-blind, placebo-controlled phase 3 study.
Post-traumatic stress disorder (PTSD) presents a major public health problem for which currently available treatments are modestly effective. We report the findings of a randomized, double-blind, placebo-controlled,... -
From:Nature Medicine (Vol. 27, Issue 6) Peer-ReviewedAuthor(s): Katie J. Ewer 1 , Jordan R. Barrett 1 , Sandra Belij-Rammerstorfer 1 , Hannah Sharpe 1 , Rebecca Makinson 1 , Richard Morter 1 , Amy Flaxman 1 , Daniel Wright 1 , Duncan Bellamy 1 , Mustapha Bittaye 1 ,...
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From:Nature Medicine (Vol. 27, Issue 6) Peer-ReviewedAgonism of the glucagon-like peptide-1 receptor (GLP-1R) results in glycemic lowering and body weight loss and is a therapeutic strategy to treat type 2 diabetes (T2D) and obesity. We developed danuglipron (PF-06882961),...
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From:Nature Medicine (Vol. 27, Issue 6) Peer-ReviewedMachine learning (ML) holds great promise for impacting healthcare delivery; however, to date most methods are tested in 'simulated' environments that cannot recapitulate factors influencing real-world clinical practice....
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From:Nature Medicine (Vol. 27, Issue 6) Peer-ReviewedAuthor(s): Carole H. Sudre 1 2 3, Benjamin Murray 1, Thomas Varsavsky 1, Mark S. Graham 1, Rose S. Penfold 4, Ruth C. Bowyer 5, Joan Capdevila Pujol 5, Kerstin Klaser 1, Michela Antonelli 1, Liane S. Canas 1, Erika...
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From:Nature Medicine (Vol. 27, Issue 6) Peer-ReviewedBiomarkers for neurodegenerative diseases are needed to improve the diagnostic workup in the clinic but also to facilitate the development and monitoring of effective disease-modifying therapies. Positron emission...
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From:Nature Medicine (Vol. 27, Issue 6) Peer-ReviewedHealth systems resilience is key to learning lessons from country responses to crises such as coronavirus disease 2019 (COVID-19). In this perspective, we review COVID-19 responses in 28 countries using a new health...
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From:Nature Medicine (Vol. 27, Issue 6) Peer-ReviewedAround 5% of the population is affected by a rare genetic disease, yet most endure years of uncertainty before receiving a genetic test. A common feature of genetic diseases is the presence of multiple rare phenotypes...
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From:Nature Medicine (Vol. 27, Issue 6) Peer-ReviewedIn a cohort of BNT162b2 (Pfizer-BioNTech) mRNA vaccine recipients (n = 1,090), we observed that spike-specific IgG antibody levels and ACE2 antibody binding inhibition responses elicited by a single vaccine dose in...
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From:Nature Medicine (Vol. 27, Issue 6) Peer-ReviewedPeople with human immunodeficiency virus (HIV) have higher rates of certain comorbidities, particularly cardiovascular disease and cancer, than people without HIV.sup.1-5. In view of observations that somatic mutations...
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From:Nature Medicine (Vol. 27, Issue 6) Peer-ReviewedAn effective vaccine is needed to end the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. Here, we assess the preliminary safety, tolerability and immunogenicity data from an ongoing single-center...
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From:Nature Medicine (Vol. 27, Issue 6) Peer-ReviewedAuthor(s): Ben Oppenheim 1 2 , Kaysie Brown 3 , Ron Waldman 4 5 Author Affiliations: (1) Metabiota, San Francisco, USA (2) Center on International Cooperation, New York University, New York, USA (3) United...
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From:Nature Medicine (Vol. 27, Issue 6) Peer-ReviewedOne Health approaches recognize the links between the environment, animals, and human disease, but these approaches are successful only with bottom-up community engagement, education, and international collaborations....
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From:Nature Medicine (Vol. 27, Issue 6) Peer-ReviewedAge is the dominant risk factor for infectious diseases, but the mechanisms linking age to infectious disease risk are incompletely understood. Age-related mosaic chromosomal alterations (mCAs) detected from genotyping...