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From:Nature Medicine (Vol. 27, Issue 8) Peer-ReviewedAuthor(s): Roberto Burioni 1 , Eric J. Topol 2 Author Affiliations: (1) Università Vita-Salute San Raffaele, Milano, Italy (2) The Scripps Research Institute, La Jolla, USA To the Editor --For the first time in...
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From:Nature Medicine (Vol. 27, Issue 8) Peer-ReviewedA randomized, double-blind, placebo-controlled, 52-week study (no. NCT03068468) evaluated gosuranemab, an anti-tau monoclonal antibody, in the treatment of progressive supranuclear palsy (PSP). In total, 486 participants...
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From:Nature Medicine (Vol. 27, Issue 8) Peer-ReviewedGene therapy (GT) has rapidly attracted renewed interest as a treatment for otherwise incurable diseases, with several GT products already on the market and many more entering clinical testing for selected indications....
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From:Nature Medicine (Vol. 27, Issue 8) Peer-ReviewedAuthor(s): Benjamin J. Cowling 1 2 , Wey Wen Lim 1 , Sarah Cobey 3 Author Affiliations: (1) World Health Organization Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, Li...
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From:Nature Medicine (Vol. 27, Issue 8) Peer-ReviewedWe evaluated the safety and efficacy of fully closed-loop insulin therapy compared with standard insulin therapy in adults with type 2 diabetes requiring dialysis. In an open-label, multinational, two-center, randomized...
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From:Nature Medicine (Vol. 27, Issue 8) Peer-ReviewedThe effectiveness of COVID-19 vaccination in preventing new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections in the general community is still unclear. Here, we used the Office for National...
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From:Nature Medicine (Vol. 27, Issue 8) Peer-ReviewedCandida auris is a fungal pathogen of high concern due to its ability to cause healthcare-associated infections and outbreaks, its resistance to antimicrobials and disinfectants and its persistence on human skin and in...
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From:Nature Medicine (Vol. 27, Issue 8) Peer-ReviewedA new trial suggests that pirfenidone, an approved treatment for idiopathic pulmonary fibrosis, may also reduce myocardial fibrosis in patients with heart failure who have a preserved left ventricular ejection fraction....
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From:Nature Medicine (Vol. 27, Issue 8) Peer-ReviewedAuthor(s): Yuanmeng Jin 1 2, Krishna Ratnam 1, Peter Y. Chuang 1, Ying Fan 1, Yifei Zhong 1, Yan Dai 1, Amin R. Mazloom 3 4, Edward Y. Chen 3 4, Vivette D'Agati 5, Huabao Xiong 6, Michael J. Ross 1, Nan Chen 2, Avi...
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From:Nature Medicine (Vol. 27, Issue 8) Peer-ReviewedMore than half of the world's population lives in areas at risk for dengue virus infection. A vaccine will be pivotal to controlling spread, however, the only licensed vaccine, Dengvaxia, has been shown to increase the...
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From:Nature Medicine (Vol. 27, Issue 8) Peer-ReviewedA new study unpacks the complexities of COVID-19 vaccine hesitancy and acceptance across low-, middle- and high-income countries. Author(s): Shingai Machingaidze 1 2 , Charles Shey Wiysonge 2 3 Author Affiliations:...
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From:Nature Medicine (Vol. 27, Issue 8) Peer-ReviewedTreatment with combined immune checkpoint blockade (CICB) targeting CTLA-4 and PD-1 is associated with clinical benefit across tumor types, but also a high rate of immune-related adverse events. Insights into biomarkers...
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From:Nature Medicine (Vol. 27, Issue 8) Peer-ReviewedDespite impressive progress, more than 50% of patients treated with CD19-targeting chimeric antigen receptor T cells (CAR19) experience progressive disease. Ten of 16 patients with large B cell lymphoma (LBCL) with...
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From:Nature Medicine (Vol. 27, Issue 8) Peer-ReviewedAI algorithms used for diagnosis and prognosis must be explainable and must not rely on a black box. Author(s): Shinjini Kundu 1 Author Affiliations: (1) The Johns Hopkins Hospital, Baltimore, USA In the wake of...
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From:Nature Medicine (Vol. 27, Issue 8) Peer-ReviewedA phase 1 trial shows promising anti-tumor activity of tumor-infiltrating-lymphocyte therapy in patients with advanced non-small-cell lung cancer. Author(s): Joshua R. Veatch 1 2 , Sylvain Simon 1 , Stanley R. Riddell...
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From:Nature Medicine (Vol. 27, Issue 8) Peer-ReviewedThe recent failure of a gene therapy for Huntington's disease was devastating for patients, but researchers remain optimistic. Author(s): Carrie Arnold 1 Author Affiliations: (1) Science writer, Richmond, USA For...
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From:Nature Medicine (Vol. 27, Issue 8) Peer-ReviewedAdoptive cell therapy using tumor-infiltrating lymphocytes (TILs) has shown activity in melanoma, but has not been previously evaluated in metastatic non-small cell lung cancer. We conducted a single-arm open-label phase...
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From:Nature Medicine (Vol. 27, Issue 8) Peer-ReviewedAuthor(s): Eseosa T. Ighodaro 1 , Erica L. Littlejohn 2 , Adesuwa I. Akhetuamhen 3 , Richard Benson 2 Author Affiliations: (1) Department of Neurology, Mayo Clinic, Rochester, USA (2) Office of Global Health and...
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From:Nature Medicine (Vol. 27, Issue 8) Peer-ReviewedCOVID-19 has shown that international collaborations and global data sharing are essential for health research, but legal obstacles are preventing data sharing for non-pandemic-related research among public researchers...
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From:Nature Medicine (Vol. 27, Issue 8) Peer-ReviewedMass vaccination has the potential to curb the current COVID-19 pandemic by protecting individuals who have been vaccinated against the disease and possibly lowering the likelihood of transmission to individuals who have...