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• Aducanumab: look before leaping.

  Author:Joel S. PerlmutterFrom:Nature Medicine (Vol. 27, Issue 9) Peer-Reviewed

  Sept. 2021846 words Article 1510LLack of rigor in approving aducanumab for Alzheimer's disease may lead to serious harm. Author(s): Joel S. Perlmutter 1 Author Affiliations: (1) Departments of Neurology, Radiology and Neuroscience and Programs in...

• A 'mix and match' approach to SARS-CoV-2 vaccination.

  Authors:Meagan E. Deming and Kirsten E. LykeFrom:Nature Medicine (Vol. 27, Issue 9) Peer-Reviewed

  Sept. 20211,558 words Article 1710LHeterologous dosing with the adenovirus-based ChAdOx1 (AstraZeneca) vaccine followed by an mRNA vaccine induced stronger immune responses than did the homologous ChAdOx1 vaccine series, according to recent immunogenicity...

• The expanding universe of checkpoint inhibitors for nasopharyngeal cancer.

  Authors:Brigette B. Y. Ma, Edwin P. Hui, and Anthony T. C. ChanFrom:Nature Medicine (Vol. 27, Issue 9) Peer-Reviewed

  Sept. 20211,391 words Article 1630LThree phase 3 studies show that an immune-checkpoint inhibitor combined with chemotherapy improves progression-free survival in recurrent or metastatic nasopharyngeal cancer. Author(s): Brigette B. Y. Ma 1 , Edwin P....

• Limited evolution of the actionable metastatic cancer genome under therapeutic pressure.

  Authors:Joris van de Haar, Louisa R. Hoes, Paul Roepman, Martijn P. Lolkema, Henk M. W. Verheul, Hans Gelderblom, et al.From:Nature Medicine (Vol. 27, Issue 9) Peer-Reviewed

  Sept. 202111,616 words Report 1550LGenomic profiling is critical for the identification of treatment options for patients with metastatic cancer, but it remains unclear how frequently this procedure should be repeated during the course of the disease. To...

• A first step toward in vivo gene editing in patients.

  Authors:Hildegard Büning and Axel SchambachFrom:Nature Medicine (Vol. 27, Issue 9) Peer-Reviewed

  Sept. 20211,415 words Article 1620LThe first preliminary evidence that in vivo gene editing in a clinical setting is feasible with no early signs of severe adverse events comes from an ongoing clinical trial to treat transthyretin amyloidosis, a fatal...

• Lessons on COVID-19 from Indigenous and remote communities of the Arctic.

  Authors:Andrey N. Petrov, Mark Welford, Nikolay Golosov, John DeGroote, Michele Devlin, Tatiana Degai, et al.From:Nature Medicine (Vol. 27, Issue 9) Peer-Reviewed

  Sept. 20211,329 words Letter to the editor 1650LAuthor(s): Andrey N. Petrov 1 2 , Mark Welford 2 , Nikolay Golosov 1 2 , John DeGroote 2 , Michele Devlin 3 , Tatiana Degai 1 4 5 , Alexander Savelyev 6 Author Affiliations: (1) ARCTICenter, University of Northern...

• Toripalimab or placebo plus chemotherapy as first-line treatment in advanced nasopharyngeal carcinoma: a multicenter randomized phase 3 trial.

  Authors:Hai-Qiang Mai, Qiu-Yan Chen, Dongping Chen, Chaosu Hu, Kunyu Yang, Jiyu Wen, et al.From:Nature Medicine (Vol. 27, Issue 9) Peer-Reviewed

  Sept. 20218,761 words Report 1420LGemcitabine-cisplatin (GP) chemotherapy is the standard first-line systemic treatment for recurrent or metastatic nasopharyngeal carcinoma (RM-NPC). In this international, double-blind, phase 3 trial (ClinicalTrials.gov...

• Malaria: a problem to be solved and a time to be bold.

  Author:Pedro L. AlonsoFrom:Nature Medicine (Vol. 27, Issue 9) Peer-Reviewed

  Sept. 20212,284 words Article 1450LVaccines alones will not be sufficient for the eradication of malaria, which will also require investment in health professionals, better use of data, and universal access to quality health services. Author(s): Pedro...

• Southeast Asia is an emerging hotspot for COVID-19.

  Authors:Thanat Chookajorn, Theerarat Kochakarn, Chaiwat Wilasang, Namfon Kotanan, and Charin ModchangFrom:Nature Medicine (Vol. 27, Issue 9) Peer-Reviewed

  Sept. 20211,109 words Letter to the editor 1370LAuthor(s): Thanat Chookajorn 1 2 3 , Theerarat Kochakarn 1 3 , Chaiwat Wilasang 4 5 , Namfon Kotanan 1 2 , Charin Modchang 4 5 Author Affiliations: (1) COVID-19 Network Investigations Alliance, Bangkok, Thailand...

• Mitochondrial DNA variants modulate N-formylmethionine, proteostasis and risk of late-onset human diseases.

  Authors:Na Cai, Aurora Gomez-Duran, Ekaterina Yonova-Doing, Kousik Kundu, Annette I. Burgess, Zoe J. Golder, et al.From:Nature Medicine (Vol. 27, Issue 9) Peer-Reviewed

  Sept. 202119,089 words Report 1570LMitochondrial DNA (mtDNA) variants influence the risk of late-onset human diseases, but the reasons for this are poorly understood. Undertaking a hypothesis-free analysis of 5,689 blood-derived biomarkers with mtDNA...

• The next phase of SARS-CoV-2 surveillance: real-time molecular epidemiology.

  Authors:Bas B. Oude Munnink, Nathalie Worp, David F. Nieuwenhuijse, Reina S. Sikkema, Bart Haagmans, Ron A. M. Fouchier, et al.From:Nature Medicine (Vol. 27, Issue 9) Peer-Reviewed

  Sept. 20217,480 words Report 1630LThe current coronavirus disease 2019 (COVID-19) pandemic is the first to apply whole-genome sequencing near to real time, with over 2 million severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) whole-genome...

• A human three-dimensional neural-perivascular 'assembloid' promotes astrocytic development and enables modeling of SARS-CoV-2 neuropathology.

  Authors:Lu Wang, David Sievert, Alex E. Clark, Sangmoon Lee, Hannah Federman, Benjamin D. Gastfriend, et al.From:Nature Medicine (Vol. 27, Issue 9) Peer-Reviewed

  Sept. 20218,343 words Report 1420LClinical evidence suggests the central nervous system is frequently impacted by SARS-CoV-2 infection, either directly or indirectly, although the mechanisms are unclear. Pericytes are perivascular cells within the brain...

• Personalizing routine lab tests with machine learning.

  Authors:Alice Tang, Tomiko Oskotsky, and Marina SirotaFrom:Nature Medicine (Vol. 27, Issue 9) Peer-Reviewed

  Sept. 20211,503 words Article 1650LMachine learning applied to electronic medical records can be used to create personalized lab-test reference ranges and to quantify disease risk, which will pave the way for precision medicine in clinical care....

• Long COVID in a prospective cohort of home-isolated patients.

  Authors:Bjørn Blomberg, Kristin Greve-Isdahl Mohn, Karl Albert Brokstad, Fan Zhou, Dagrun Waag Linchausen, Bent-Are Hansen, et al.From:Nature Medicine (Vol. 27, Issue 9) Peer-Reviewed

  Sept. 20215,910 words Report 1480LLong-term complications after coronavirus disease 2019 (COVID-19) are common in hospitalized patients, but the spectrum of symptoms in milder cases needs further investigation. We conducted a long-term follow-up in a...

• Open science in space.

  From:Nature Medicine (Vol. 27, Issue 9) Peer-Reviewed

  Sept. 2021971 words Editorial 1230LScientific and medical research conducted in space can bring benefits for all humankind, but this will require commercial space flight companies to embrace open data principles. Author Affiliations: The recent lift...

• Melding microbiome and nutritional science with early child development.

  Authors:Robert Y. Chen, Ishita Mostafa, Matthew C. Hibberd, Subhasish Das, Hannah M. Lynn, Daniel M. Webber, et al.From:Nature Medicine (Vol. 27, Issue 9) Peer-Reviewed

  Sept. 20212,432 words Article 1750LPrograms for treating malnutrition in children should consider how food formulations affect postnatal gut microbiome development. Author(s): Robert Y. Chen 1 2 , Ishita Mostafa 3 , Matthew C. Hibberd 1 2 , Subhasish...

• Safety, immunogenicity and efficacy of PfSPZ Vaccine against malaria in infants in western Kenya: a double-blind, randomized, placebo-controlled phase 2 trial.

  Authors:Martina Oneko, Laura C. Steinhardt, Reuben Yego, Ryan E. Wiegand, Phillip A. Swanson, Natasha KC, et al.From:Nature Medicine (Vol. 27, Issue 9) Peer-Reviewed

  Sept. 202112,255 words Report 1620LThe radiation-attenuated Plasmodium falciparum sporozoite (PfSPZ) vaccine provides protection against P. falciparum infection in malaria-naïve adults. Preclinical studies show that T cell-mediated immunity is required...

• Effects of a large-scale social media advertising campaign on holiday travel and COVID-19 infections: a cluster randomized controlled trial.

  Authors:Emily Breza, Fatima Cody Stanford, Marcella Alsan, Burak Alsan, Abhijit Banerjee, Arun G. Chandrasekhar, et al.From:Nature Medicine (Vol. 27, Issue 9) Peer-Reviewed

  Sept. 20218,353 words Report 1400LDuring the Coronavirus Disease 2019 (COVID-19) epidemic, many health professionals used social media to promote preventative health behaviors. We conducted a randomized controlled trial of the effect of a Facebook...

• Reduction in life expectancy in Brazil after COVID-19.

  Authors:Marcia C. Castro, Susie Gurzenda, Cassio M. Turra, Sun Kim, Theresa Andrasfay, and Noreen GoldmanFrom:Nature Medicine (Vol. 27, Issue 9) Peer-Reviewed

  Sept. 20217,178 words Report 1420LBrazil has been heavily affected by coronavirus disease 2019 (COVID-19). In this study, we used data on reported total deaths in 2020 and in January-April 2021 to measure and compare the death toll across states. We...

• A government-led effort to identify correlates of protection for COVID-19 vaccines.

  Authors:Richard A. Koup, Ruben O. Donis, Peter B. Gilbert, Andrew W. Li, Najaf A. Shah, and Christopher R. HouchensFrom:Nature Medicine (Vol. 27, Issue 9) Peer-Reviewed

  Sept. 20211,295 words Letter to the editor 1640LAuthor(s): Richard A. Koup 1 , Ruben O. Donis 2 , Peter B. Gilbert 3 , Andrew W. Li 4 , Najaf A. Shah 4 , Christopher R. Houchens 2 Author Affiliations: (1) Vaccine Research Center, National Institutes of Health,...