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    Academic Journals

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• Publisher Correction: Clinical evolution, genetic landscape and trajectories of clonal hematopoiesis in SAMD9/SAMD9L syndromes.

  Authors:Sushree S. Sahoo, Victor B. Pastor, Charnise Goodings, Rebecca K. Voss, Emilia J. Kozyra, Amina Szvetnik, et al.From:Nature Medicine (Vol. 27, Issue 12) Peer-Reviewed

  Dec. 2021398 words Correction notice, B... 2250LAuthor(s): Sushree S. Sahoo 1 2, Victor B. Pastor 2, Charnise Goodings 1, Rebecca K. Voss 2, Emilia J. Kozyra 2 3, Amina Szvetnik 2, Peter Noellke 2, Michael Dworzak 4, Jan Starý 5, Franco Locatelli 6, Riccardo Masetti...

• Avelumab maintenance in advanced urothelial carcinoma: biomarker analysis of the phase 3 JAVELIN Bladder 100 trial.

  Authors:Thomas Powles, Srikala S. Sridhar, Yohann Loriot, Joaquim Bellmunt, Xinmeng Jasmine Mu, Keith A. Ching, et al.From:Nature Medicine (Vol. 27, Issue 12) Peer-Reviewed

  Dec. 202111,349 words Report 1530LIn a recent phase 3 randomized trial of 700 patients with advanced urothelial cancer (JAVELIN Bladder 100; NCT02603432), avelumab/best supportive care (BSC) significantly prolonged overall survival relative to BSC alone...

• The Yearbook.

  Author:Karen O'LearyFrom:Nature Medicine (Vol. 27, Issue 12) Peer-Reviewed

  Dec. 20211,127 words Article We take stock of who made headlines this year for enlightening or disappointing us in 2021. Author(s): Karen O'Leary 1 Author Affiliations: (1) Nature Medicine, The Nobel Prize awarders Most likely not to award...

• A new era in obesity treatment.

  Author:Karen O'LearyFrom:Nature Medicine (Vol. 27, Issue 12) Peer-Reviewed

  Dec. 2021130 words Brief article 1600LAuthor(s): Karen O'Leary 1 Author Affiliations: (1) Nature Medicine, N. Engl. J. Med. 384, 989-1002 (2021) Lancet 397, 971-984 (2021) Pharmacological interventions are recommended for certain people with...

• Viral loads of Delta-variant SARS-CoV-2 breakthrough infections after vaccination and booster with BNT162b2.

  Authors:Matan Levine-Tiefenbrun, Idan Yelin, Hillel Alapi, Rachel Katz, Esma Herzel, Jacob Kuint, et al.From:Nature Medicine (Vol. 27, Issue 12) Peer-Reviewed

  Dec. 20213,802 words Report 1570LThe effectiveness of the coronavirus disease 2019 (COVID-19) BNT162b2 vaccine in preventing disease and reducing viral loads of breakthrough infections (BTIs) has been decreasing, concomitantly with the rise of the Delta...

• A phase 1/2 trial of an immune-modulatory vaccine against IDO/PD-L1 in combination with nivolumab in metastatic melanoma.

  Authors:Julie Westerlin Kjeldsen, Cathrine Lund Lorentzen, Evelina Martinenaite, Eva Ellebaek, Marco Donia, Rikke Boedker Holmstroem, et al.From:Nature Medicine (Vol. 27, Issue 12) Peer-Reviewed

  Dec. 202115,448 words Report 1610LAnti-programmed death (PD)-1 (aPD1) therapy is an effective treatment for metastatic melanoma (MM); however, over 50% of patients progress due to resistance. We tested a first-in-class immune-modulatory vaccine...

• Rethinking aspirin for heart health.

  Author:Karen O'LearyFrom:Nature Medicine (Vol. 27, Issue 12) Peer-Reviewed

  Dec. 2021106 words Brief article 1620LAuthor(s): Karen O'Leary 1 Author Affiliations: (1) Nature Medicine, U.S. Preventive Services Task...

• Evidence-based COVID-19 policy-making in schools.

  Authors:Elizabeth A. Stuart and David W. DowdyFrom:Nature Medicine (Vol. 27, Issue 12) Peer-Reviewed

  Dec. 20211,368 words Report 1490LNew research can help policymakers make evidence-based decisions about the risks and benefits of in-person schooling; strategic use of the available data will be key to getting this right. Author(s): Elizabeth A....

• Publisher Correction: Neurological complications after first dose of COVID-19 vaccines and SARS-CoV-2 infection.

  Authors:Martina Patone, Lahiru Handunnetthi, Defne Saatci, Jiafeng Pan, Srinivasa Vittal Katikireddi, Saif Razvi, et al.From:Nature Medicine (Vol. 27, Issue 12) Peer-Reviewed

  Dec. 2021333 words Correction notice, B... 2020LAuthor(s): Martina Patone 1, Lahiru Handunnetthi 2 3, Defne Saatci 1, Jiafeng Pan 4, Srinivasa Vittal Katikireddi 5, Saif Razvi 6, David Hunt 7, Xue W. Mei 1, Sharon Dixon 1, Francesco Zaccardi 8, Kamlesh Khunti 8, Peter...

• mRNA vaccines offer hope for HIV.

  Author:Lynn MorrisFrom:Nature Medicine (Vol. 27, Issue 12) Peer-Reviewed

  Dec. 20211,501 words Report 1560LmRNA technology may be uniquely positioned to tackle a major hurdle for HIV vaccines: the elicitation of broadly cross-reactive neutralizing antibodies. A preclinical study takes the first step toward this goal....

• COVID-19 timeline of events.

  Author:Paul WebsterFrom:Nature Medicine (Vol. 27, Issue 12) Peer-Reviewed

  Dec. 20211,487 words Chronology 1410LThe COVID-19 pandemic continued to rage in 2021, but this was increasingly an unequal pandemic, with rich countries receiving millions of doses of vaccine and ending lockdowns and travel bans. It was also a year when...

• Decoding the building blocks of life.

  Author:Karen O'LearyFrom:Nature Medicine (Vol. 27, Issue 12) Peer-Reviewed

  Dec. 2021164 words Brief article 1410LAuthor(s): Karen O'Leary 1 Author Affiliations: (1) Nature Medicine, National Human Genome Research...

• Long-term ecological assessment of intracranial electrophysiology synchronized to behavioral markers in obsessive-compulsive disorder.

  Authors:Nicole R. Provenza, Sameer A. Sheth, Evan M. Dastin-van Rijn, Raissa K. Mathura, Yaohan Ding, Gregory S. Vogt, et al.From:Nature Medicine (Vol. 27, Issue 12) Peer-Reviewed

  Dec. 202113,165 words Report 1550LDetection of neural signatures related to pathological behavioral states could enable adaptive deep brain stimulation (DBS), a potential strategy for improving efficacy of DBS for neurological and psychiatric disorders....

• Eight unanswered questions about the COVID-19 pandemic.

  Author:Mike MayFrom:Nature Medicine (Vol. 27, Issue 12) Peer-Reviewed

  Dec. 20212,677 words Discussion 1360LWe asked experts around the world what surprised them about SARS-CoV-2 and COVID-19, and what questions remain unanswered. Author(s): Mike May 1 Author Affiliations: (1) Freelance writer and editor, Seattle, USA...

• Author Correction: Dectin 1 activation on macrophages by galectin 9 promotes pancreatic carcinoma and peritumoral immune tolerance.

  Authors:Donnele Daley, Vishnu R. Mani, Navyatha Mohan, Neha Akkad, Atsuo Ochi, Daniel W. Heindel, et al.From:Nature Medicine (Vol. 27, Issue 12) Peer-Reviewed

  Dec. 2021642 words Correction notice 1970LAuthor(s): Donnele Daley 1 , Vishnu R. Mani 1 , Navyatha Mohan 1 , Neha Akkad 1 , Atsuo Ochi 1 , Daniel W. Heindel 2 , Ki Buom Lee 1 , Constantinos P. Zambirinis 1 , Gautam S. D. Balasubramania Pandian 1 , Shivraj...

• PPIL4 is essential for brain angiogenesis and implicated in intracranial aneurysms in humans.

  Authors:Tanyeri Barak, Emma Ristori, A. Gulhan Ercan-Sencicek, Danielle F. Miyagishima, Carol Nelson-Williams, Weilai Dong, et al.From:Nature Medicine (Vol. 27, Issue 12) Peer-Reviewed

  Dec. 202116,847 words Report 1470LIntracranial aneurysm (IA) rupture leads to subarachnoid hemorrhage, a sudden-onset disease that often causes death or severe disability. Although genome-wide association studies have identified common genetic variants...

• Underdiagnosis bias of artificial intelligence algorithms applied to chest radiographs in under-served patient populations.

  Authors:Laleh Seyyed-Kalantari, Haoran Zhang, Matthew B. A. McDermott, Irene Y. Chen, and Marzyeh GhassemiFrom:Nature Medicine (Vol. 27, Issue 12) Peer-Reviewed

  Dec. 20217,700 words Report 1570LArtificial intelligence (AI) systems have increasingly achieved expert-level performance in medical imaging applications. However, there is growing concern that such AI systems may reflect and amplify human bias, and...

• Promotion of non-evidence-based therapeutics within patient-led Long COVID support groups.

  Authors:Vicky van der Togt, Sammie Mcfarland, Marta Esperti, Elizabeth Semper, Sara Citrenbaum, and Jeremy S. RossmanFrom:Nature Medicine (Vol. 27, Issue 12) Peer-Reviewed

  Dec. 20211,465 words Letter to the editor 1500LAuthor(s): Vicky van der Togt 1 2 , Sammie Mcfarland 3 , Marta Esperti 4 , Elizabeth Semper 5 , Sara Citrenbaum 1 , Jeremy S. Rossman 1 6 Author Affiliations: (1) Research-Aid Networks, Chicago, USA (2) Long Covid...

• Neurocognitive and hypokinetic movement disorder with features of parkinsonism after BCMA-targeting CAR-T cell therapy.

  Authors:Oliver Van Oekelen, Adolfo Aleman, Bhaskar Upadhyaya, Sandra Schnakenberg, Deepu Madduri, Somali Gavane, et al.From:Nature Medicine (Vol. 27, Issue 12) Peer-Reviewed

  Dec. 20218,351 words Report 1550LB-cell maturation antigen (BCMA) is a prominent tumor-associated target for chimeric antigen receptor (CAR)-T cell therapy in multiple myeloma (MM). Here, we describe the case of a patient with MM who was enrolled in the...

• A malaria vaccine at last.

  Author:Karen O'LearyFrom:Nature Medicine (Vol. 27, Issue 12) Peer-Reviewed

  Dec. 2021141 words Brief article 1620LAuthor(s): Karen O'Leary 1 Author Affiliations: (1) Nature Medicine, World Health Organizationhttps://www.who.int/news/item/06-10-2021-who-recommends-groundbreaking-malaria-vaccine-for-children-at-risk (2021)...