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From:PLoS ONE (Vol. 18, Issue 3) Peer-ReviewedNon-alcoholic steatohepatitis (NASH) is the progressive form of nonalcoholic fatty liver disease (NAFLD) and a disease with high unmet medical need. Platform trials provide great benefits for sponsors and trial...
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From:PLoS ONE (Vol. 18, Issue 3) Peer-ReviewedVaccine hesitancy is defined as a delay in acceptance of vaccines despite its availability, caused by many determinants. Our study presents the key reasons, determinants and characteristics associated with COVID-19...
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From:PLoS ONE (Vol. 18, Issue 3) Peer-ReviewedBackground The one-minute sit-to-stand-test (1-min STST) is a quick, space saving test to evaluate functional capacity. Exercise testing plays an important role in the long-term follow-up of pulmonary hypertension (PH)...
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From:PLoS ONE (Vol. 18, Issue 3) Peer-ReviewedBackground Emergency Departments serve as a main entry point for patients into hospitals, and the team, the core of which is formed by doctors and nurses needs to make sense of and respond to the constant flux of...
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From:PLoS ONE (Vol. 18, Issue 3) Peer-ReviewedBackground COVID-19 hesitancy among women planning to become pregnant, who are pregnant, and who are breast-feeding is still a global phenomenon. Unfortunately, there is a lack of national educational programs that...
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From:PLoS ONE (Vol. 18, Issue 3) Peer-ReviewedCOVID-19-related fear negatively affects the public's psychological well-being and health behaviours. Although psychological distress including depression and anxiety under COVID-19 is well-established in literature,...
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From:PLoS ONE (Vol. 18, Issue 3) Peer-ReviewedThe main objective of this paper is to study the impact of the Ambient Air Quality Standard (2012) on the green innovation of Chinese firms in polluting industries. The analysis features "leverage effect" of Porter...
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From:PLoS ONE (Vol. 18, Issue 3) Peer-ReviewedObjectives Transurethral resection of prostate (TURP) and laser prostate surgery are common surgeries for benign prostate hyperplasia (BPH). We conducted an investigation using hospital database to evaluate the...
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From:PLoS ONE (Vol. 18, Issue 3) Peer-ReviewedA common cause of frontotemporal dementia (FTD) are nonsense mutations in the progranulin (GRN) gene. Because nonsense mutations activate the nonsense-mediated RNA decay (NMD) pathway, we sought to inhibit this RNA...
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From:PLoS ONE (Vol. 18, Issue 3) Peer-ReviewedThe contribution and regulation of various CD4.sup.+ T cell lineages that occur with remitting vs progressive courses in sarcoidosis are poorly understood. We developed a multiparameter flow cytometry panel to sort these...
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From:PLoS ONE (Vol. 18, Issue 3) Peer-ReviewedFor many different types of businesses, additive manufacturing has great potential for new product and process development in many different types of businesses including automotive industry. On the other hand, there are...
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From:PLoS ONE (Vol. 18, Issue 3) Peer-ReviewedBackground Human Immunodeficiency Virus self-test (HIVST) refers to a process where a person collects his or her own specimen (blood or oral), performs a test and interprets the results. The interpretation of results...
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From:PLoS ONE (Vol. 18, Issue 3) Peer-ReviewedUsing a relatively small training set of .sup.~ 16 thousand images from macromolecular crystallisation experiments, we compare classification results obtained with four of the most widely-used convolutional deep-learning...
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From:PLoS ONE (Vol. 18, Issue 3) Peer-ReviewedHelicobacter pylori (H. pylori) is a common human pathogen causing inflammation. Recent studies have suggested a sophisticated interplay between mitochondria, innate immunity and inflammatory response, thus proposing...
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From:PLoS ONE (Vol. 18, Issue 3) Peer-ReviewedA novel economic impact model is proposed by this paper to analyze the impact of economic downturn on the air quality in Wuhan during the epidemic period, and to explore the effective solutions to improve the urban air...
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From:PLoS ONE (Vol. 18, Issue 3) Peer-ReviewedVarious studies have described epigenetic inheritance through sperms. However, the detailed mechanisms remain unclear. In this study, we focused on DNA methylation in mice treated with valproic acid (VPA), an inducer of...
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From:PLoS ONE (Vol. 18, Issue 3) Peer-ReviewedDespite the traditional use of average values for determining physical demands, the intermittent and fluctuating nature of team sports may lead to underestimation of the most demanding scenarios. All the most demanding...
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From:PLoS ONE (Vol. 18, Issue 3) Peer-ReviewedObjective The study aimed to demonstrate the feasibility of an unassisted and community-based HIV self-testing (HIVST) distribution model and to evaluate its acceptability among men-having-sex-with-men (MSM) and...
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From:PLoS ONE (Vol. 18, Issue 3) Peer-ReviewedWithin the realms of human thoughts on nature, Fourier analysis is considered as one of the greatest ideas currently put forwarded. The Fourier transform shows that any periodic function can be rewritten as the sum of...
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From:PLoS ONE (Vol. 18, Issue 3) Peer-ReviewedBackground Australian immigration policy resulted in large numbers of children being held in locked detention. We examined the physical and mental health of children and families who experienced immigration detention....