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    Academic Journals

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• Bone Marrow-Derived Cell Therapies to Heal Long-Bone Nonunions: A Systematic Review and Meta-Analysis--Which Is the Best Available Treatment?

  Authors:Silvia Palombella, Silvia Lopa, Silvia Gianola, Luigi Zagra, Matteo Moretti, and Arianna B. LovatiFrom:Stem Cells International (Vol. 2020) Peer-Reviewed

  Jan. 20206,086 words Clinical report 1450LNonunions represent one of the major indications for clinical settings with stem cell-based therapies. The objective of this research was to systematically assess the current evidence for the efficacy of bone...

• Therapeutic Potential of Mesenchymal Stem Cells and Their Secretome in the Treatment of Glaucoma.

  Authors:C. Randall Harrell, Crissy Fellabaum, Aleksandar Arsenijevic, Bojana Simovic Markovic, Valentin Djonov, and Vladislav VolarevicFrom:Stem Cells International (Vol. 2020) Peer-Reviewed

  Jan. 20208,382 words Clinical report 1670LGlaucoma represents a group of progressive optic neuropathies characterized by gradual loss of retinal ganglion cells (RGCs), the neurons that conduct visual information from the retina to the brain. Elevated intraocular...

• Bone Tissue Regeneration in the Oral and Maxillofacial Region: A Review on the Application of Stem Cells and New Strategies to Improve Vascularization.

  Authors:Vivian Wu, Marco N. Helder, Nathalie Bravenboer, Christiaan M. ten Bruggenkate, Jianfeng Jin, Jenneke Klein-Nulend, et al.From:Stem Cells International (Vol. 2020) Peer-Reviewed

  Jan. 202011,722 words Article 1530LBone tissue engineering techniques are a promising alternative for the use of autologous bone grafts to reconstruct bone defects in the oral and maxillofacial region. However, for successful bone regeneration, adequate...

• Human Adipose-Derived Hydrogel Characterization Based on In Vitro ASC Biocompatibility and Differentiation.

  Authors:Omair A. Mohiuddin, Benjamen T. O'Donnell, J. Nicholas Poche, Rida Iftikhar, Rachel M. Wise, Jessica M. Motherwell, et al.From:Stem Cells International (Vol. 2020) Peer-Reviewed

  Jan. 20207,701 words Article 1350LHydrogels serve as three-dimensional scaffolds whose composition can be customized to allow attachment and proliferation of several different cell types. Extracellular matrix-derived hydrogels are considered close...

• The Effect of Blood-Derived Products on the Chondrogenic and Osteogenic Differentiation Potential of Adipose-Derived Mesenchymal Stem Cells Originated from Three Different Locations.

  Authors:Markus Neubauer, Olga Kuten, Christoph Stotter, Karina Kramer, Andrea De Luna, Thomas Muellner, et al.From:Stem Cells International (Vol. 2020) Peer-Reviewed

  Jan. 202010,770 words Article 1340LBackground. Adipose-derived mesenchymal stem cells (AD-MSCs) from fat tissue considered "surgical waste" during joint surgery may provide a potent source for regenerative medicine. Intra-articular, homologous fat tissue...

• Human Adipose-Derived Stem Cells Promote Seawater-Immersed Wound Healing by Activating Skin Stem Cells via the EGFR/MEK/ERK Pathway.

  Authors:Jiachao Xiong, Boyao Ji, Liujun Wang, Yazhou Yan, Zhixiao Liu, Shuo Fang, et al.From:Stem Cells International (Vol. 2020) Peer-Reviewed

  Jan. 20207,176 words Article 1370LSeawater (SW) immersion can increase the damage of skin wounds and produce refractory wounds. However, few studies have been conducted to investigate the mechanisms of SW immersion on skin wounds. In our current study,...

• Insulin Enhances the In Vitro Osteogenic Capacity of Flexor Tendon-Derived Progenitor Cells.

  Authors:Sushmitha S. Durgam, Nadine N. Altmann, Haley E. Coughlin, Audrey Rollins, and Laura D. HostnikFrom:Stem Cells International (Vol. 2020) Peer-Reviewed

  Jan. 20205,882 words Article 1400LThere is increased incidence of tendon disorders and decreased tendon healing capacity in people with diabetes mellitus (DM). Recent studies have also suggested pathological ossification in repair tendon of people with...

• Autologous Mesenchymal Stem Cell Transplantation in Multiple Sclerosis: A Meta-Analysis.

  Authors:Yang Zhou, Xin Zhang, Hang Xue, Lingling Liu, Jie Zhu, and Tao JinFrom:Stem Cells International (Vol. 2020) Peer-Reviewed

  Jan. 20203,867 words Article 1410LMultiple sclerosis (MS) is considered to be a central nervous system (CNS) chronic inflammatory demyelinating disease, affecting more than 2 million individuals worldwide. In this meta-analysis, we aimed to assess the...

• GLP-1 Gene-Modified Human Umbilical Cord Mesenchymal Stem Cell Line Improves Blood Glucose Level in Type 2 Diabetic Mice.

  Authors:Ying Chang, Mingxin Dong, Yan Wang, Haotian Yu, Chengbiao Sun, Xin Jiang, et al.From:Stem Cells International (Vol. 2020) Peer-Reviewed

  Jan. 20204,083 words Article 1400LType 2 diabetes constitutes a serious threat to the health of patients, but there is currently no ideal treatment in the clinic. Glucagon-like peptide-1 and human umbilical cord mesenchymal stem cells have been confirmed...

• Human Fat-Derived Mesenchymal Stem Cells Xenogenically Implanted in a Rat Model Show Enhanced New Bone Formation in Maxillary Alveolar Tooth Defects.

  Authors:Andrew Wofford, Austin Bow, Steven Newby, Seth Brooks, Rachel Rodriguez, Tom Masi, et al.From:Stem Cells International (Vol. 2020) Peer-Reviewed

  Jan. 20207,028 words Article 1480LBackground. Due to restorative concerns, bone regenerative therapies have garnered much attention in the field of human oral/maxillofacial surgery. Current treatments using autologous and allogenic bone grafts suffer...

• FGF-2-Induced Human Amniotic Mesenchymal Stem Cells Seeded on a Human Acellular Amniotic Membrane Scaffold Accelerated Tendon-to-Bone Healing in a Rabbit Extra-Articular Model.

  Authors:Jun Zhang, Ziming Liu, Yuwan Li, Qi You, Jibin Yang, Ying Jin, et al.From:Stem Cells International (Vol. 2020) Peer-Reviewed

  Jan. 20207,735 words Article 1380LBackground. FGF-2 (basic fibroblast growth factor) has a positive effect on the proliferation and differentiation of many kinds of MSCs. Therefore, it represents an ideal molecule to facilitate tendon-to-bone healing....

• Paracrine Proangiogenic Function of Human Bone Marrow-Derived Mesenchymal Stem Cells Is Not Affected by Chronic Kidney Disease.

  Authors:Femke C.C. van Rhijn-Brouwer, Bas W.M. van Balkom, Diana A. Papazova, Dienty H.M. Hazenbrink, Anke J. Meijer, Isaac Brete, et al.From:Stem Cells International (Vol. 2020) Peer-Reviewed

  Jan. 20207,405 words Article 1280LBackground. Cell-based therapies are being developed to meet the need for curative therapy in chronic kidney disease (CKD). Bone marrow- (BM-) derived mesenchymal stromal cells (MSCs) enhance tissue repair and induce...

• The Role of Adipose-Derived Stem Cells, Dermal Regenerative Templates, and Platelet-Rich Plasma in Tissue Engineering-Based Treatments of Chronic Skin Wounds.

  Authors:Massimo Conese, Luigi Annacontini, Annalucia Carbone, Elisa Beccia, Liberato Roberto Cecchino, Domenico Parisi, et al.From:Stem Cells International (Vol. 2020) Peer-Reviewed

  Jan. 202013,741 words Article 1560LThe continuous improvements in the field of both regenerative medicine and tissue engineering have allowed the design of new and more efficacious strategies for the treatment of chronic or hard-to-heal skin wounds, which...

• Bioactive Molecules for Skin Repair and Regeneration: Progress and Perspectives.

  Authors:Deyun Chen, Qian Hou, Lingzhi Zhong, Yali Zhao, Meirong Li, and Xiaobing FuFrom:Stem Cells International (Vol. 2020) Peer-Reviewed

  Jan. 202010,461 words Article 1480LSkin regeneration is a vexing problem in the field of regenerative medicine. A bioactive molecule-based strategy has been frequently used in skin wound healing in recent years. Bioactive molecules are practical tools for...

• Intrathecal Infusion of Autologous Adipose-Derived Regenerative Cells in Autoimmune Refractory Epilepsy: Evaluation of Safety and Efficacy.

  Authors:Elzbieta Szczepanik, Hanna Mierzewska, Dorota Antczak-Marach, Anna Figiel-Dabrowska, Iwona Terczynska, Jolanta Tryfon, et al.From:Stem Cells International (Vol. 2020) Peer-Reviewed

  Jan. 20208,022 words Article 1360LObjective/Purpose. Evaluation of efficacy and safety of autologous adipose-derived regenerative cells (ADRCs) treatment in autoimmune refractory epilepsy. Patients. Six patients with proven or probable autoimmune...

• Puerarin Relieved Compression-Induced Apoptosis and Mitochondrial Dysfunction in Human Nucleus Pulposus Mesenchymal Stem Cells via the PI3K/Akt Pathway.

  Authors:Donghua Huang, Yizhong Peng, Kaige Ma, Xiangcheng Qing, Xiangyu Deng, Zhiliang Li, et al.From:Stem Cells International (Vol. 2020) Peer-Reviewed

  Jan. 20209,226 words Article 1420LPuerarin (PUR), an 8-C-glucoside of daidzein extracted from Pueraria plants, is closely related to autophagy, reduced reactive oxygen species (ROS) production, and anti-inflammatory effects, but its effects on human...

• Efficient Differentiation of Mouse Induced Pluripotent Stem Cells into Alveolar Epithelium Type II with a BRD4 Inhibitor.

  Authors:Toru Momozane, Eriko Fukui, Soichiro Funaki, Makoto Fujii, Yuhei Kinehara, Emiko Ito, et al.From:Stem Cells International (Vol. 2020) Peer-Reviewed

  Jan. 20207,627 words Article 1410LRegenerative medicine has continued to progress for lung biology and lung diseases. Efforts have focused on a variety of different applications for pluripotent stem cells. Several groups have reported successful methods...

• Transplantation Site Affects the Outcomes of Adipose-Derived Stem Cell-Based Therapy for Retinal Degeneration.

  Authors:Chengyu Hu, Huanzhi La, Xuancheng Wei, Yue Zhou, Qingjian Ou, Zhiyang Chen, et al.From:Stem Cells International (Vol. 2020) Peer-Reviewed

  Jan. 20207,527 words Article 1450LAdipose-derived stem cells (ASCs) have shown a strong protective effect on retinal degenerative diseases (RDD) after being transplanted into the subretinal space in an animal model. Recently, several clinical trials have...

• Melatonin Reverses the Loss of Stemness Induced by TNF-[alpha] in Human Bone Marrow Mesenchymal Stem Cells through Upregulation of YAP Expression.

  Authors:Xudong Wang, Tongzhou Liang, Jincheng Qiu, Xianjian Qiu, Bo Gao, Wenjie Gao, et al.From:Stem Cells International (Vol. 2020) Peer-Reviewed

  Jan. 20207,301 words Article 1320LMesenchymal stem cells (MSCs) are promising candidates for tissue regeneration and disease treatment. However, long-term in vitro culture results in loss of MSC stemness. The inflammation that occurs at stem cell...

• Regulation and Directing Stem Cell Fate by Tissue Engineering Functional Microenvironments: Scaffold Physical and Chemical Cues.

  Authors:Fei Xing, Lang Li, Changchun Zhou, Cheng Long, Lina Wu, Haoyuan Lei, et al.From:Stem Cells International (Vol. 2020) Peer-Reviewed

  Jan. 202011,916 words Article 1460LIt is well known that stem cells reside within tissue engineering functional microenvironments that physically localize them and direct their stem cell fate. Recent efforts in the development of more complex and...