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    Academic Journals

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• Epigenetic Clock: DNA Methylation in Aging.

  Authors:Shuang Jiang and Yuchen GuoFrom:Stem Cells International (Vol. 2020) Peer-Reviewed

  July 31, 20207,105 words Article 1450LAging, which is accompanied by decreased organ function and increased disease incidence, limits human lifespan and has attracted investigators for thousands of years. In recent decades, with the rapid development of...

• Mesenchymal Stem Cell Secretome Enhancement by Nicotinamide and Vasoactive Intestinal Peptide: A New Therapeutic Approach for Retinal Degenerative Diseases.

  Authors:Maria L. Alonso-Alonso, Girish K. Srivastava, Ricardo Usategui-Martin, Maria T. Garcia-Gutierrez, Jose Carlos Pastor, and Ivan Fernandez-BuenoFrom:Stem Cells International (Vol. 2020) Peer-Reviewed

  July 31, 20209,461 words Article 1390LMesenchymal stem cells (MSC) secrete neuroprotective molecules that may be useful as an alternative to cell transplantation itself. Our purpose was to develop different pharmaceutical compositions based on conditioned...

• Retinoic Acid Signal Negatively Regulates Osteo/Odontogenic Differentiation of Dental Pulp Stem Cells.

  Authors:Jiangyi Wang, Guoqing Li, Lei Hu, Fei Yan, Bin Zhao, Xiaoshan Wu, et al.From:Stem Cells International (Vol. 2020) Peer-Reviewed

  July 31, 20206,525 words Article 1370LRetinoic acid (RA) signal is involved in tooth development and osteogenic differentiation of mesenchymal stem cells (MSCs). Dental pulp stem cells (DPSCs) are one of the useful MSCs in tissue regeneration. However, the...

• The Role of Caspase-4 and NLRP1 in MCF7 Cell Pyroptosis Induced by hUCMSC-Secreted Factors.

  Authors:Yang Jiao, Linlin Wang, Lin Lu, Jianjun Liu, Xin Li, Hongbo Zhao, et al.From:Stem Cells International (Vol. 2020) Peer-Reviewed

  July 31, 20207,571 words Article 1400LMesenchymal stem cells (MSCs) are being widely investigated for the development of novel therapeutic approaches for different cancers, including breast cancer, the leading form of cancer in women. Our previous study...

• Immunomodulatory Properties of Stem Cells in Periodontitis: Current Status and Future Prospective.

  Authors:Mengyuan Wang, Jiang Xie, Cong Wang, Dingping Zhong, Liang Xie, and Hongzhi FangFrom:Stem Cells International (Vol. 2020) Peer-Reviewed

  July 31, 202010,096 words Article 1470LPeriodontitis is the sixth-most prevalent chronic inflammatory disease and gradually devastates tooth-supporting tissue. The complexity of periodontal tissue and the local inflammatory microenvironment poses great...

• Combined Transplantation of Adipose Tissue-Derived Stem Cells and Endothelial Progenitor Cells Improve Diabetic Erectile Dysfunction in a Rat Model.

  Authors:Qiyun Yang, Wanmei Chen, Chi Zhang, Yun Xie, Yong Gao, Cuncan Deng, et al.From:Stem Cells International (Vol. 2020) Peer-Reviewed

  July 31, 20207,053 words Article 1460LErectile dysfunction (ED) is a common complication in men suffered with diabetic mellitus. Stem cell transplantation is a promising strategy for the treatment of diabetic ED (DED). In this study, we evaluated whether...

• Coupled CRC 2D and ALI 3D Cultures Express Receptors of Emerging Viruses and Are More Suitable for the Study of Viral Infections Compared to Conventional Cell Lines.

  Authors:Siyu Xia, Jun Liu, Yan Yang, Ming Wu, Lina Ye, Si Chen, et al.From:Stem Cells International (Vol. 2020) Peer-Reviewed

  July 31, 20206,863 words Article 1310LInfections of emerging and reemerging viruses (SARS-CoVs, influenza H1N1, etc.) largely and globally affect human health. Animal models often fail to reflect a physiological status because of species tropism of virus...

• Treatment of Diabetic Foot with Autologous Stem Cells: A Meta-Analysis of Randomized Studies.

  Authors:Jiezhi Dai, Chaoyin Jiang, Hua Chen, and Yimin ChaiFrom:Stem Cells International (Vol. 2020) Peer-Reviewed

  July 31, 20203,236 words Article 1310LBackground. This meta-analysis was to evaluate the efficacy of autologous stem cell administration for the treatment of diabetic foot. Methods. The electronic databases included PubMed, EMBASE, BIOSIS, Cochrane central,...

• Galectin-3 Secreted by Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Reduces Aberrant Tau Phosphorylation in an Alzheimer Disease Model.

  Authors:Hoon Lim, Dahm Lee, Wan Kyu Choi, Soo Jin Choi, Wonil Oh, and Dong Hyun KimFrom:Stem Cells International (Vol. 2020) Peer-Reviewed

  July 31, 20208,618 words Article 1450LThe formation of neurofibrillary tangles has been implicated as an important pathological marker for Alzheimer's disease (AD). Studies have revealed that the inhibition of abnormal hyperphosphorylation and aggregation of...

• Cathepsin K Deficiency Impaired Ischemia-Induced Neovascularization in Aged Mice.

  Authors:Xueling Yue, Haiying Jiang, Ying Xu, Manli Xia, and Xian-Wu ChengFrom:Stem Cells International (Vol. 2020) Peer-Reviewed

  July 31, 20205,138 words Article 1450LBackground. Aging is a major risk factor for cardiovascular disease. Cysteine protease cathepsin K (CatK) has been implicated in the process of angiogenesis, but the exact roles of individual CatK in vessel formation...

• Human Cardiac Fibroblast Number and Activation State Modulate Electromechanical Function of hiPSC-Cardiomyocytes in Engineered Myocardium.

  Authors:Cassady E. Rupert, Tae Yun Kim, Bum-Rak Choi, and Kareen L.K. CoulombeFrom:Stem Cells International (Vol. 2020) Peer-Reviewed

  July 31, 202010,905 words Article 1520LCardiac tissue engineering using hiPSC-derived cardiomyocytes is a promising avenue for cardiovascular regeneration, pharmaceutical drug development, cardiotoxicity evaluation, and disease modeling. Limitations to these...

• MEST Regulates the Stemness of Human Periodontal Ligament Stem Cells.

  Authors:Daigaku Hasegawa, Kana Hasegawa, Hiroshi Kaneko, Shinichiro Yoshida, Hiromi Mitarai, Mai Arima, et al.From:Stem Cells International (Vol. 2020) Peer-Reviewed

  July 31, 20206,697 words Article 1400LPeriodontal ligament (PDL) stem cells (PDLSCs) have been reported as a useful cell source for periodontal tissue regeneration. However, one of the issues is the difficulty of obtaining a sufficient number of PDLSCs for...

• TRAF6 Promotes Gastric Cancer Cell Self-Renewal, Proliferation, and Migration.

  Authors:Mengting Yang, Meng Jin, Kailong Li, Haifeng Liu, Xiaxia Yang, Xiaobei Zhang, et al.From:Stem Cells International (Vol. 2020) Peer-Reviewed

  July 31, 20204,812 words Article 1340LGastric cancer is the third most common type of tumor associated with death. TRAF6 belongs to the tumor necrosis factor receptor-associated factor family and has been demonstrated to be involved in tumor progression in...

• Mesenchymal Stem/Stromal Cell-Mediated Mitochondrial Transfer and the Therapeutic Potential in Treatment of Neurological Diseases.

  Authors:Deqiang Han, Xin Zheng, Xueyao Wang, Tao Jin, Li Cui, and Zhiguo ChenFrom:Stem Cells International (Vol. 2020) Peer-Reviewed

  July 31, 202010,970 words Article 1510LMesenchymal stem/stromal cells (MSCs) are multipotent stem cells that can be derived from various tissues. Due to their regenerative and immunomodulatory properties, MSCs have been extensively researched and tested for...

• Screening and Functional Pathway Analysis of Pulmonary Genes Associated with Suppression of Allergic Airway Inflammation by Adipose Stem Cell-Derived Extracellular Vesicles.

  Authors:Sung-Dong Kim, Shin Ae Kang, Yong-Wan Kim, Hak Sun Yu, Kyu-Sup Cho, and Hwan-Jung RohFrom:Stem Cells International (Vol. 2020) Peer-Reviewed

  July 31, 20205,389 words Article 1440LBackground. Although mesenchymal stem cell- (MSC-) derived extracellular vesicles (EVs) are as effective as MSCs in the suppression of allergic airway inflammation, few studies have explored the molecular mechanisms of...

• The [m.sup.6] A Methylation-Regulated AFF4 Promotes Self-Renewal of Bladder Cancer Stem Cells.

  Authors:Qian Gao, Jin Zheng, Zegui Ni, Pengli Sun, Congcong Yang, Maosheng Cheng, et al.From:Stem Cells International (Vol. 2020) Peer-Reviewed

  July 31, 20205,050 words Article 1490LThe dynamic [N.sup.6]-methyladenosine ([m.sup.6]A) modification of mRNA plays a role in regulating gene expression and determining cell fate. However, the functions of [m.sup.6]A mRNA modification in bladder cancer stem...

• The Effects of Mesenchymal Stem Cells on Antimelanoma Immunity Depend on the Timing of Their Administration.

  Authors:Dragana Miloradovic, Dragica Miloradovic, Bojana Simovic Markovic, Aleksandar Acovic, Carl Randall Harrell, Valentin Djonov, et al.From:Stem Cells International (Vol. 2020) Peer-Reviewed

  July 31, 20206,070 words Article 1600LThere is still a lively debate about whether mesenchymal stem cells (MSCs) promote or suppress antitumor immune response. Although several possible explanations have been proposed, including different numbers of injected...

• The Exposure to Osteoarthritic Synovial Fluid Enhances the Immunomodulatory Profile of Adipose Mesenchymal Stem Cell Secretome.

  Authors:Adriana Cifu, Rossana Domenis, Massimo Pozzi-Mucelli, Paolo Di Benedetto, Araldo Causero, Massimo Moretti, et al.From:Stem Cells International (Vol. 2020) Peer-Reviewed

  July 31, 20207,696 words Clinical report 1510LObjective. Several clinical studies have proposed the infusion of adipose mesenchymal stem cells (AMSCs) as an alternative therapy for joint diseases with inflammatory components, such as osteoarthritis. Indeed, AMSCs...

• Photoaging Skin Therapy with PRP and ADSC: A Comparative Study.

  Authors:Luiz Charles-de-Sa, Natale Gontijo-de-Amorim, Andrea Sbarbati, Donatella Benati, Paolo Bernardi, Radovan Borojevic, et al.From:Stem Cells International (Vol. 2020) Peer-Reviewed

  July 31, 20209,346 words Clinical report 1530LBackground. Stem cells from adipose tissue (ADSCs) and platelet-rich plasma (PRP) are innovative modalities that arise due to their regenerative potential. Objective. The aim of this study was to characterize possible...

• Mesenchymal Stem Cell Therapy Using Human Umbilical Cord in a Rat Model of Autoimmune-Induced Premature Ovarian Failure.

  Authors:Zhe Wang, Quanwei Wei, Hao Wang, Linxiao Han, Hongjian Dai, Xiaoxin Qian, et al.From:Stem Cells International (Vol. 2020) Peer-Reviewed

  July 31, 20207,028 words Article 1380LPremature ovarian failure (POF) is one of the principal causes of female infertility, and although its causes are complex and diverse, autoimmune deficiency may be involved. Human umbilical cord mesenchymal stem cells...