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From:eLife (Vol. 11) Peer-ReviewedAtherosclerosis preferentially occurs in atheroprone vasculature where human umbilical vein endothelial cells are exposed to disturbed flow. Disturbed flow is associated with vascular inflammation and focal distribution....
From:eLife (Vol. 11) Peer-ReviewedPathogenic germline CDKN2A variants are associated with an increased risk of pancreatic ductal adenocarcinoma (PDAC). CDKN2A variants of uncertain significance (VUSs) are reported in up to 4.3% of patients with PDAC and...
From:eLife (Vol. 11) Peer-ReviewedParvalbumin-positive (PV.sup.+) [gamma]-aminobutyric acid (GABA) interneurons are critically involved in producing rapid network oscillations and cortical microcircuit computations, but the significance of PV.sup.+ axon...
From:eLife (Vol. 11) Peer-ReviewedRecent initiatives to improve translation of findings from animal models to human disease have focussed on reproducibility but quantifying the relevance of animal models remains a challenge. Here, we use comparative...
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