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    Academic Journals

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• Fine-tuning of [beta]-catenin in mouse thymic epithelial cells is required for postnatal T-cell development.

  Authors:Sayumi Fujimori, Izumi Ohigashi, Hayato Abe, Yosuke Matsushita, Toyomasa Katagiri, Makoto M Taketo, et al.From:eLife (Vol. 11) Peer-Reviewed

  Jan. 19, 202216,243 words Article 1500LIn the thymus, the thymic epithelium provides a microenvironment essential for the development of functionally competent and self-tolerant T cells. Previous findings showed that modulation of Wnt/[beta]-catenin signaling...

• Connexins evolved after early chordates lost innexin diversity.

  Authors:Georg Welzel and Stefan SchusterFrom:eLife (Vol. 11) Peer-Reviewed

  Jan. 19, 20229,474 words Report 1360LGap junction channels are formed by two unrelated protein families. Non-chordates use the primordial innexins, while chordates use connexins that superseded the gap junction function of innexins. Chordates retained...

• Sensitizing Staphylococcus aureus to antibacterial agents by decoding and blocking the lipid flippase MprF.

  Authors:Christoph J Slavetinsky, Janna N Hauser, Cordula Gekeler, Jessica Slavetinsky, André Geyer, Alexandra Kraus, et al.From:eLife (Vol. 11) Peer-Reviewed

  Jan. 19, 202215,130 words Article 1590LThe pandemic of antibiotic resistance represents a major human health threat demanding new antimicrobial strategies. Multiple peptide resistance factor (MprF) is the synthase and flippase of the phospholipid...

• Correction: Neural excitability and sensory input determine intensity perception with opposing directions in initial cortical responses.

  Authors:Tilman Stephani, Alice Hodapp, Mina Jamshidi Idaji, Arno Villringer, and Vadim NikulinFrom:eLife (Vol. 11) Peer-Reviewed

  Jan. 19, 2022185 words Correction notice, B... 1430LByline: Tilman Stephani, Alice Hodapp, Mina Jamshidi Idaji, Arno Villringer, Vadim Nikulin ************************************************************************ Stephani T, Hodapp A, Jamshidi Idaji M, Villringer...

• Comprehensive interrogation of the ADAR2 deaminase domain for engineering enhanced RNA editing activity and specificity.

  Authors:Dhruva Katrekar, Yichen Xiang, Nathan Palmer, Anushka Saha, Dario Meluzzi, and Prashant MaliFrom:eLife (Vol. 11) Peer-Reviewed

  Jan. 19, 202217,356 words Article 1500LAdenosine deaminases acting on RNA (ADARs) can be repurposed to enable programmable RNA editing, however their exogenous delivery leads to transcriptome-wide off-targeting, and additionally, enzymatic activity on certain...

• Structural organization and dynamics of FCHo2 docking on membranes.

  Authors:Fatima El Alaoui, Ignacio Casuso, David Sanchez-Fuentes, Charlotte Arpin-Andre, Raissa Rathar, Volker Baecker, et al.From:eLife (Vol. 11) Peer-Reviewed

  Jan. 19, 202214,349 words Article 1490LClathrin-mediated endocytosis (CME) is a central trafficking pathway in eukaryotic cells regulated by phosphoinositides. The plasma membrane phosphatidylinositol-4,5-bisphosphate (PI(4,5)P.sub.2) plays an instrumental...