Sprouty-2 regulates oncogenic K-ras in lung development and tumorigenesis

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From: Genes & Development(Vol. 21, Issue 6)
Publisher: Cold Spring Harbor Laboratory Press
Document Type: Article
Length: 47 words

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Abstract :

The phenotype of a mouse engineered to harbor a germline oncogenic K-ras mutation is described. It is found that the Ras/MAPK (mitogen-activated protein kinase) antagonist Sprouty-2 acts as a tumor suppressor in K-ras mediated lung tumorigenesis and regulates the functioning in the pathogenesis of the Ras disease.

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Gale Document Number: GALE|A165473190