Biosynthesis of Tropolones in Streptomyces spp.: Interweaving Biosynthesis and Degradation of Phenylacetic Acid and Hydroxylations on the Tropone Ring

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Date: June 15, 2018
From: Applied and Environmental Microbiology(Vol. 84, Issue 12)
Publisher: American Society for Microbiology
Document Type: Report
Length: 54 words

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Abstract :

The article determines the DHT biosynthetic pathway by heterologous expression, gene deletion, and biotransformation. TrlH is an unusual bifunctional protein bearing an N-terminal prephenate dehydratase domain and a C-terminal chorismate mutase domain.The study reveals a natural association of anabolism of chorismate and phenylpyruvate, catabolism of phenylacetic acid, and biosynthesis of tropolones in Streptomyces spp.

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Gale Document Number: GALE|A543770316