Genetic variants of the EGFR ligand-binding domain and their association with structural alterations in Arab cancer patients.

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From: BMC Research Notes(Vol. 14, Issue 1)
Publisher: BioMed Central Ltd.
Document Type: Report
Length: 3,335 words
Lexile Measure: 1530L

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Abstract :

Objective This study aimed to identify novel genetic variants in the CR2 extracellular domain of the epidermal growth factor receptor (EGFR) in healthy individuals and patients with six different types of adenocarcinoma, in Arabian peninsula populations. It also aimed to investigate the effects of these variants on the EGFR structure and their eventual relevance to tumorigenesis. Results We detected seven new EGFR genetic variants in 168 cancer patients and 114 controls. A SNP rs374670788 was more frequent in bladder cancer but not significantly associated to. However, a missense mutation (V550M) was significantly associated to colon, ovary, lung, bladder and thyroid cancer samples (p Keywords: EGFR protein, Missense mutation, Arabs, Adenocarcinoma, Single nucleotide polymorphism, CR1/CR2 EGFR domains, EGFR R521K polymorphism, Arabian Peninsula population

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Gale Document Number: GALE|A661413749