Repeated mild traumatic brain injury impairs fracture healing in male mice.

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Date: Jan. 29, 2022
From: BMC Research Notes(Vol. 15, Issue 1)
Publisher: BioMed Central Ltd.
Document Type: Report
Length: 3,209 words
Lexile Measure: 1670L

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Abstract :

Objectives The goal of this study was to evaluate the long-term impact of repeated (r) mild traumatic brain injury (mTBI) on the healing of fractures in a mouse model. Ten week-old male mice were subjected to r-mTBI once per day for 4 days followed by closed femoral fracture using a three-point bending technique, 1 week post impact and fracture healing phenotype evaluated at 20 weeks of age. Results Micro-CT analysis of the fracture callus region at nine weeks post fracture revealed reduced bone volume (30%, p Keywords: r-mTBI, Bone fracture, Mice, Three-point bending, Micro-CT

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Gale Document Number: GALE|A693521348