Synthesis of aromatic lactone analogues of Lipoxin A4.

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Date: Feb. 9, 2022
From: BMC Research Notes(Vol. 15, Issue 1)
Publisher: BioMed Central Ltd.
Document Type: Report
Length: 1,776 words
Lexile Measure: 1440L

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Abstract :

Objective Synthesis of novel aromatic Lipoxin A4 lactone analogues. Results Novel para-substituted aromatic lactone analogues of Lipoxin A4 have been synthesized in a convergent manner with six steps in the longest linear sequence in 12-13% yields, employing 2-deoxy-d-ribose as a chiral pool starting material and the classical E-selective Wittig olefination. Keywords: Lipoxin analogues, Aromatics, Wittig olefination, Lactones

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Gale Document Number: GALE|A693688122