Predictors of Response to Oral Medications and Low-Histamine Diet in Patients with Chronic Urticaria.

Citation metadata

Publisher: Hindawi Limited
Document Type: Article
Length: 5,077 words
Lexile Measure: 1300L

Document controls

Main content

Abstract :

Background. Chronic urticaria (CU) is comprised of diverse phenotypes, and thus, a shift towards a precision medical approach is warranted in its management. Methods. This study enrolled 78 patients with CU. Serum erythrocyte sedimentation rate, hemoglobin, hematocrit, eosinophil count, IgE, antinuclear antibody (ANA), and serum diamine oxidase (DAO) levels of the patients were measured and were compared according to the patient's response to second-generation antihistamines (sgAH), corticosteroids, leukotriene receptor antagonist (LTRA), H[sub.2] blockers, and low-histamine diet. Results. Age- and sex-adjusted logistic regression analysis showed that patients with duration of CU 3 years (adjusted odd ratio [aOR]=4.39) and a DAOlevel 50 years (aOR=0.02), duration of chronicurticaria 3 years (aOR=0.06), and an ANAtiter≥1:80 (aOR=0.03) were significantly and inversely associated with corticosteroid response. A low-histamine diet response was significantly associated with LTRA response (aOR=67.29). In addition, a DAO level

Source Citation

Source Citation   

Gale Document Number: GALE|A697669220