Evolution of hepatitis C viral quasispecies and hepatic injury in perinatally infected children followed prospectively

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Publisher: National Academy of Sciences
Document Type: Author abstract
Length: 263 words
Lexile Measure: 60L

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Abstract :

Perinatal infection with hepatitis C virus (HCV) is characterized by a wide range of alanine aminotransferase (ALT) levels. The mechanisms responsible for this variability are unknown. We examined whether the evolution of the HCV quasispecies was associated with different ALT profiles in perinatally infected children. Sequences within HCV envelope 1 and 2 genes, inclusive of the hypervariable region 1, the viral load, and the nascent humoral immunity were analyzed in serial serum samples from 12 perinatally infected children prospectively followed for a median of 53 months. These patients were selected to represent two different ALT patterns during the first year of life: 6 had high levels (maximum values ranging from 4.2 to 30 times the normal upper limit), and 6 had normal or slightly elevated levels ( perinatal hepatitis C virus infection | genetic variability alanine aminotransferase levels

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Gale Document Number: GALE|A147218028