Emerging Adults Carrying a CDH1 Pathogenic or Likely Pathogenic Variant Face Diet and Lifestyle Challenges after Total Gastrectomy.

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Authors: Yi Liu and Rachael Lopez
Date: May 2022
Publisher: Elsevier Science Publishers
Document Type: Report; Brief article
Length: 304 words

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Abstract :

Keywords Emerging adults; CDH1; Total gastrectomy; Registered dietitian; Nutrition Emerging adults with a CDH1 pathogenetic or likely pathogenetic variant face a life-altering decision whether to undergo prophylactic total gastrectomy or to have frequent endoscopies for gastric cancer risk management. They are in a unique life stage with distinct characteristics, such as identity finding, career seeking, relationship exploring, establishing financial independence, and planning for or pursuing pregnancy. Research has shown that these emerging adults heavily weighed dietary and nutrition concerns after prophylactic total gastrectomy in their decision making for both timing of surgery and whether they should or should not undergo the surgery. These concerns are valid because of the significant dietary and lifestyle modifications that emerging adults need to commit to in order to prevent common sequelae after prophylactic total gastrectomy, which include early satiety, nausea, dumping syndrome, bile reflux, excessive weight loss, micronutrient deficiencies, and metabolic bone disorders. Therefore, working with a multidisciplinary team with expertise in CDH1 and hereditary diffuse gastric cancer, including a registered dietitian nutritionist, is essential for this population. Author Affiliation: (1) Genetic Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (2) Clinical Center Nutrition Department, National Institutes of Health, Bethesda, Maryland (3) US Public Health Service, Washington, District of Columbia * Address correspondence to: Yi Liu, MS, CGC, National Cancer Institute, Center for Cancer Research, Genetics Branch, 37 Convent Dr, Building 37, Bethesda, MD 20892. Article History: Received 24 June 2021; Accepted 22 December 2021 (footnote) STATEMENT OF POTENTIAL CONFLICT OF INTEREST No potential conflict of interest was reported by the authors. (footnote) FUNDING/SUPPORT This project received in kind support from the Intramural Research Program at the National Institutes of Health, National Cancer Institute, Center for Cancer Research, Genetics Branch. Byline: Yi Liu, MS [yi.liu2@nih.gov] (1,*), Rachael Lopez, MPH, RD, CSO (2,3)

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Gale Document Number: GALE|A700982614