Selective resistance to vasoactive effects of insulin in muscle resistance arteries of obese Zucker (falfa) rats

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Publisher: American Physiological Society
Document Type: Clinical report
Length: 266 words

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Abstract :

Obesity is related to insulin resistance and hypertension, but the underlying mechanisms are unclear. Insulin exerts both vasodilator and vasoconstrictor effects on muscle resistance arteries, which may be differentially impaired in obesity. Objectives: To investigate whether vasodilator and vasoconstrictor effects of insulin are impaired in muscle resistance arteries of obese rats and the roles of Akt and endothelial NO synthase (eNOS). Methods/Results: Effects of insulin were studied in resistance arteries isolated from cremaster muscles of lean and obese Zucker rats. In arteries of lean rats, insulin increased activity of both NO and endothelin (ET-1), resulting in a neutral effect under basal conditions. In arteries of obese rats, insulin induced endothelin-mediated vasoconstriction (- 15 [+ or -] 5% at 1 nM, P microcirculation; obesity; hypertension; nitric oxide

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Gale Document Number: GALE|A171770207