Risk of Cancer in Children of Parents Occupationally Exposed to Hydrocarbon Solvents and Engine Exhaust Fumes: A Register-Based Nested Case-Control Study from Sweden (1960-2015).

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From: Environmental Health Perspectives(Vol. 130, Issue 7)
Publisher: National Institute of Environmental Health Sciences
Document Type: Report
Length: 6,860 words
Lexile Measure: 1810L

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Abstract :

Background: It remains unclear whether parental occupational exposure to hydrocarbon solvents (HCS) or engine exhaust fumes (EEF) is associated with higher risks of cancer in the offspring. Objectives: Our aim was to estimate relative risks of childhood cancers associated with maternal or paternal exposure to aliphatic/alicyclic, aromatic, or chlorinated HCS or gasoline/diesel EEF. Methods: We conducted a case-control study in which individuals Results: Maternal exposure to aromatic HCS was associated with non-Hodgkin lymphoma (OR = 1.64; 95% CI: 1.05, 2.58), aliphatic/alicyclic HCS with germ cell tumors (OR = 1.52; 95% CI: 0.89, 2.59), and gasoline/diesel EEF with astrocytoma (OR= 1.40; 95% CI: 1.04, 1.88), myeloid leukemia (OR = 1.53; 95% CI: 0.84, 2.81), lymphomas (OR = 1.60; 95% CI: 0.85, 3.02 for Hodgkin; OR = 1.44; 95% CI: 0.71, 2.91 for non-Hodgkin), and epithelial tumors (OR=1.51; 95% CI: 0.93, 2.44). Paternal exposure to gasoline EEF was associated with Hodgkin lymphoma (OR = 1.21;95% CI: 1.01, 1.44) and soft tissue sarcomas (OR=1.22; 95% CI: 1.00, 1.48). No notable difference was observed between higher and lower exposure. Discussion: Our findings suggest that occupational exposure to HCS or EEF, especially in the mother, may increase the risk of some childhood cancers. They add to the growing literature on adverse effects from HCS and EEF in the child, but replication of these associations in other populations is warranted. https://doi.org/10.1289/EHP11035

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Gale Document Number: GALE|A712308611