News in brief

Citation metadata

Date: Sept. 2013
Publisher: Expert Reviews Ltd.
Document Type: Article
Length: 613 words
Lexile Measure: 1520L

Document controls

Main content

Article Preview :

Allergic inflammation caused by inappropriate immune responses to some types of food has become a major public health issue. Over the past 10 years, the prevalence of food allergies has increased by nearly 20%, affecting an estimated 6 million people in the USA. Eosinophilic esophagitis (EoE) is a food allergy associated disease caused by inflammation in response to foods such as eggs, nuts, milk, wheat and soy. EoE can lead to debilitating esophageal dysfunction.

In order to examine the cause of EoE researchers at Penn state University (PA, USA) lead by David Artis used a mouse model of EoE to investigate its development. It has previously been found that in the esophagus of human patients with EoE there is a large population of immune cells suggesting an immune contribution to pathogenesis of the disease, in addition genetic mutations in the gene encoding for thymic stromal lymphopoietin (TSLP) a cytokine involved in allergic inflammation...

Source Citation

Source Citation   

Gale Document Number: GALE|A345113372