Byline: Peter Liu, Division of Infectious Diseases, University of Pennsylvania, Philadelphia (Drs Liu, Short, and Koenig); and Indian Health Service, Chinle, Arizona, and University of Pennsylvania Perelman School of Medicine, Philadelphia (Dr Stewart).; Leslie Stewart; William R. Short; Helen Koenig Abstract BACKGROUND AND OBJECTIVES: There is a paucity of guidance on HIV pre-exposure prophylaxis (PrEP) implementation in an academic medical center. The objectives of this study were to describe interventions by a multidisciplinary PrEP task force at an academic medical center and compare metrics of PrEP implementation pre- and post-creation of this entity. METHODS: The interventions of the task force are described within the rubric of the PrEP care continuum. Participants were adults prescribed PrEP for greater than or equal to 30 days at 9 clinical sites across a university health system. Metrics of PrEP implementation were compared over 12-month intervals before and after the creation of the task force. RESULTS: An increased proportion of participants had HIV testing within 7 days of new PrEP prescriptions (92% vs 63%, P CONCLUSIONS: A multidisciplinary team that focuses on optimizing PrEP delivery along each step of the care continuum may facilitate PrEP scale-up and best practices in an academic setting.