Effects of a multicomponent intervention to slow mild cognitive impairment progression: A randomized controlled trial.

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Date: Jan. 2022
Publisher: Elsevier B.V.
Document Type: Report
Length: 445 words

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Keywords Cognitive function; Dementia; Depression; Elderly; Mild cognitive impairment; Patients; Physical function Abstract Background Mild cognitive impairment affects 36% of people aged [greater than or equal to]65 years in China, around 50% of whom will develop dementia within 3 years. Early intervention can slow disease progression and delay the onset of dementia; however, whether a multicomponent intervention can decelerate the progression of mild cognitive impairment remains unknown. Objective To evaluate the effects of a multicomponent intervention to slow mild cognitive impairment progression in Chinese patients. Design Randomized controlled trial. Setting(s) and participants This study was conducted in two large regional communities in Guangzhou, China. Patients aged [greater than or equal to] 65 years diagnosed with mild cognitive impairment were included. Methods A total of 112 eligible participants were assigned to receive either a 6-month multicomponent intervention or usual care from September 2019 until January 2021. Data were collected at the beginning of the study and at 1, 3, and 6 months thereafter. The primary outcomes were cognitive function, comprehensive physical capacity, depression, and quality of life. Analysis followed the intention-to-treat principle. A generalized estimating equation was used to determine intervention effects. Results At baseline, clinical characteristics did not differ significantly between groups. Significant interaction effects between time and group were detected (p Conclusions This study demonstrates the beneficial effects of a multicomponent intervention on cognitive function, physical function, depression symptoms, and quality of life in people with mild cognitive impairment in the East Asia region. The effectiveness and feasibility of this intervention program suggest that its application should be promoted in community settings to delay the progression of disease in people with mild cognitive impairment. Registration number:ChiCTR1900026042 Tweetable abstract: The multicomponent intervention improves cognitive/physical function, depression, and quality of life, slowing cognitive impairment progression. Author Affiliation: (a) School of Nursing, Jinan University, Guangzhou, China (b) Nursing Department, The First Affiliated Hospital of Jinan University, Guangzhou, China (c) Nursing Department, Shenzhen People's Hospital, Shenzhen, China * Corresponding author at: School of Nursing, Jinan University, Guangzhou, China. Article History: Received 29 March 2021; Revised 30 September 2021; Accepted 5 October 2021 (footnote)1 Equally contributing authors. Byline: Qiao-hong Yang (a,1), Xia Lyu (c,1), Qing-ran Lin (b,1), Zi-wen Wang (a), Li Tang (a), Yu Zhao (a), Qi-yuan Lyu [yuanqlv@163.com] (a,*)

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Gale Document Number: GALE|A686459881