Carbonyl iron is a more effective hemoglobin repletion agent than electrolytic or reduced iron powder in rats

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Date: Apr. 2002
Publisher: North Dakota Academy of Science
Document Type: Report
Length: 502 words
Lexile Measure: 1460L

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Fortification of food with elemental iron (Fe) powder is designed to reduce Fe deficiency anemia, but little or no verification exists as to the efficacy of elemental Fe powders used widely as food fortificants today. Our objective was to determine the bioavailability of six different commercially-produced (~2001) elemental Fe powders, collected by SUSTAIN (1).


The relative biological value (RBV) of the Fe powders was determined (2) using the AOAC hemoglobin repletion/ slope ratio method (3) in 220 weanling, male Sprague-Dawley rats. After dietary Fe depletion (24 d; ~1.5 mg Fe/kg AIN93G diet), rats consumed a repletion diet (14 d; AIN93G diet) fortified with one of six elemental Fe powders (each ~12, 24, and 36 mg Fe/kg), ferrous sulfate (FeS[O.sub.4] x [H.sub.2]O; ~6, 12,...

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Gale Document Number: GALE|A167977163