Abstract :
Keywords Bronchopulmonary dysplasia; BPD; Pulmonary hypertension; PH; Histology; Histological; Premature; Extremely premature; Autopsy; Postmortem; Clinical definition Highlights * Bronchopulmonary Dysplasia (BPD) is the commonest complication of prematurity. * BPD is clinically defined by treatment with oxygen for [greater than or equal to]28 days. * Pulmonary hypertension (PH) often coexists with BPD and increases mortality. * We report histologic BPD and PH in preterm infants treated with oxygen for * Current clinical definitions do not allow for early diagnosis of BPD and PH. Abstract Bronchopulmonary Dysplasia (BPD), the commonest complication of prematurity, is defined by treatment with oxygen for [greater than or equal to]28 days. Pulmonary hypertension (PH) often coexists with BPD and is associated with increased mortality. In 42 autopsies, histological changes of BPD and PH were demonstrated in 25 % and 65 % respectively of preterm infants Author Affiliation: (a) Division of Neonatal-Perinatal Medicine, Children's Hospital of Michigan, Hutzel Women's Hospital and Wayne State University School of Medicine, Detroit, MI, United States of America (b) Division of Neonatal-Perinatal Medicine, Department of Pediatrics, Children's Hospital of Michigan, Hutzel Women's Hospital and Wayne State University School of Medicine, Detroit, MI, United States of America (c) Division of Neonatal-Perinatal Medicine, Department of Pediatric Pathology, Children's Hospital of Michigan, Hutzel Women's Hospital and Wayne State University School of Medicine, Detroit, MI, United States of America (d) Department of Pediatrics, Northwestern University, Chicago, IL, United States of America * Corresponding author at: Department of Pediatrics, Wayne State University, 340 E. Canfield, Detroit, MI, United States of America. Article History: Received 6 April 2022; Revised 13 June 2022; Accepted 14 June 2022 (footnote)[white star] The results reported in this manuscript were presented at the Annual Midwest Society for Pediatric Research Scientific Meeting in October 2018 and the Pediatric Academic Societies' Annual Meeting in April 2019. (footnote)1 Amelia Stone is a resident in Pediatrics at Northwestern University. (footnote)2 Sara Koussa is a third-year medical student at Wayne State University School of Medicine. Byline: Amelia Stone (b,d,1), Janet Poulik (c), Sara Koussa (b,2), Yuemin Xin (b), Amit Sharma (a,b), Beena G. Sood [bsood@med.wayne.edu] (a,b,*)