Novel Mycobacterium tuberculosis complex isolate from a wild chimpanzee

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From: Emerging Infectious Diseases(Vol. 19, Issue 6)
Publisher: U.S. National Center for Infectious Diseases
Document Type: Article
Length: 5,124 words
Lexile Measure: 1530L

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Abstract :

Tuberculosis (TB) is caused by gram-positive bacteria known as the Mycobacterium tuberculosis complex (MTBC). MTBC include several human-associated lineages and several variants adapted to domestic and, more rarely, wild animal species. We report an M. tuberculosis strain isolated from a wild chimpanzee in Cote d'Ivoire that was shown by comparative genomic and phylogenomic analyses to belong to a new lineage of MTBC, closer to the human-associated lineage 6 (also known as M. africanum West Africa 2) than to the other classical animal-associated MTBC strains. These results show that the general view of the genetic diversity of MTBC is limited and support the possibility that other MTBC variants exist, particularly in wild mammals in Africa. Exploring this diversity is crucial to the understanding of the biology and evolutionary history of this widespread infectious disease.

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Gale Document Number: GALE|A335409845