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Date: Mar. 2013
From: Expert Review of Molecular Diagnostics(Vol. 13, Issue 2)
Publisher: Expert Reviews Ltd.
Document Type: Report
Length: 685 words
Lexile Measure: 1450L

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Submandibular gland biopsy could be the first definitive molecular diagnostic of Parkinson's disease.

A research group based at the Mayo Clinic (AZ, USA) and the Banner Sun Health Research Institute (AZ, USA) have found that molecular analysis of a biopsy of the submandibular salivary gland could definitively diagnose Parkinson's disease (PD). Their findings suggest that molecular diagnosis of PD could be possible in living patients. This research has been published recently in the Journal of Neuropathology and Experimental Neurology .

The group studied large segment samples and needle core samples of the submandibular gland taken from 128 subjects. These subjects included individuals with PD, Alzheimer's disease, Lewy body disease and elderly subjects with no reported neurological disease. These samples were tested for Lewy-type [alpha]-synucleinopathy by immunohistochemical staining. In the large segments the researchers observed immunoreactive nerve fibers in all 28 PD subjects and in the needle core samples from frozen submandibular glands, 17 of 19 PD samples stained positive for Lewy-type [alpha]-synucleinopathy. The research team suggest that these results could improve the...

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Gale Document Number: GALE|A321864205