Effectiveness and Safety of Acupoint Application of Guan Xin Su He Pill (å å¿èå丸) for Patients with Chronic Stable Angina Pectoris: A Multi-Center, Randomized Controlled Trial.

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Date: Nov. 2021
From: Chinese Journal of Integrative Medicine(Vol. 27, Issue 11)
Publisher: Springer
Document Type: Report
Length: 436 words

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Keywords: acupoint application; chronic stable angina pectoris; clinical efficacy randomized controlled trial Abstract Objective To assess the clinical effectiveness of acupoint application (AP) of Guan Xin Su He Pill (å å¿èå丸, GXSHP) for patients with chronic stable angina pectoris (CSAP). Methods This study was carried out in 3 local hospitals in Chengdu, China. After baseline evaluation, eligible patients were randomly assigned to the placebo application for acupoints (PAA) group or the herbal application for acupoints (HAA) group. Patients in the HAA group underwent AP with herbal powder, which was mainly GXSHP, and patients in the PAA group underwent AP with sham drugs. For each treatment session, unilateral acupoints including Neiguan (PC 6), Danzhong (RN 17), Xinshu (BL 15) and Jueyinshu (BL 14), were stimulated for both groups. AP was performed 3 times a week with a 2-day interval for 4 weeks. The primary outcome was the frequency of angina pectoris attacks per week, while the secondary outcomes included angina pain intensity measured by the Visual Analogue Scale (VAS), dose of rescue oral drugs (nitroglycerin), scores on the Seattle Angina Questionnaire (SAQ), Self-Rating Anxiety Scale scores (SAS) and Self-Rating Depression Scale scores (SDS). Clinical outcomes were measured at week 0, 4 and 8. The safety of AP of GXSHP treatment for CSAP were assessed. Results A total of 121 patients were enrolled. Baseline characteristics were comparable across the 2 groups. After treatment, the angina attack numbers in the HAA group were significantly reduced from 11.00 to 4.81 (P Conclusion AP of GXSHP is a safe and effective treatment for CSAP patients (Registration No. NCT02029118). Author Affiliation: (1) Department of Acupuncture and Moxibustion, Hospital of Chengdu University of Traditional Chinese Medicine, 610075, Chengdu, China (2) Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, 610075, Chengdu, China (k) acuresearch@126.com Article History: Registration Date: 08/13/2021 Accepted Date: 04/02/2020 Online Date: 08/13/2021 Byline: De-hua Li (1), Jin Xie (2), Yu-lan Ren (2), Hui Zheng (2), Jun-ling Lyu (2), Jun-yan Leng (2), Ling-lin Zhang (2), Jie Zhang (2), Hai-long Fan (2), Fan-rong Liang (corresponding author) (2, k)

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Gale Document Number: GALE|A681341749