The Helicobacter pylori HypA.UreE2 Complex contains a Novel High Affinity Ni(II)-Binding Site

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Date: May 22, 2018
From: Biochemistry(Vol. 57, Issue 20)
Publisher: American Chemical Society
Document Type: Report
Length: 59 words

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Abstract :

The study examines the nickel-binding properties and protein-protein interactions of HypA and UreE2 using isothermal titration calorimetry and fluorometric methods under neutral and acidic pH conditions to gain insight into the roles played by HypA in urease maturation and the results reveal that HypA and UreE2 form a stable complex with micromolar affinity that protects UreE from hydrolytic degradation.

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Gale Document Number: GALE|A542240411