Effects of pentoxifylline and alpha lipoic acid on methotrexate-induced damage in liver and kidney of rats

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Publisher: Elsevier B.V.
Document Type: Article
Length: 154 words

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To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.etap.2015.04.003 Byline: Ilkay Armagan, Dilek Bayram, Ibrahim Aydin Candan, Ayse Yigit, Erdal Celik, Hamit Hakan Armagan, Abdulhadi Cihangir Uguz Abstract: * We investigated effects of PTX and ALA against MTX-induced liver and kidney tissue damage. * We analysed biochemically, histochemically and immunohistocemically. * The protective effect of ALA was found to be more. * And so, MTX treatment should be supported with ALA to avoid adverse effects. Author Affiliation: (a) Department of Histology and Embryology, School of Medicine, Suleyman Demirel University, Isparta, Turkey (b) Department of Medical Genetics, School of Medicine, Suleyman Demirel University, Isparta, Turkey (c) Biochemistry Division, Isparta State Hospital, Isparta, Turkey (d) Department of Emergency Medicine, School of Medicine, Suleyman Demirel University, Isparta, Turkey (e) Department of Biophysics, School of Medicine, Suleyman Demirel University, Isparta, Turkey Article History: Received 29 December 2014; Revised 17 March 2015; Accepted 4 April 2015

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Gale Document Number: GALE|A419724140