Relation of aplastic anaemia to use of chloramphenicol eye drops in two international case-control studies

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From: British Medical Journal(Vol. 316, Issue 7132)
Publisher: BMJ Publishing Group Ltd.
Document Type: Article
Length: 874 words

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Although the use of chloramphenicol eye drops is thought to cause aplastic anaemia,[1] this side effect has not been studied critically. We examined the use of ocular chloramphenicol in two population based case-control studies conducted with the same methods.[2 3]

Subjects, methods, and results

The data from the international granulocytosis and aplastic anaemia study were collected over varying times from 1980 to 1986 in Israel and in Ulm and Berlin (Germany), Milan (Italy), Budapest (Hungary), Sofia (Bulgaria), and Stockholm and Uppsala (Sweden); the total base population was about 19 million.[2] Data collection continued independently in Sweden until 1992. The Thai study was conducted from 1989 to 1994 in Bangkok and from 1990 to 1994 in Khonkaen and Songkla; the total population was about 21 million.[3]

In both studies patients with aplastic anaemia were identified by regular telephone contacts with all hospitals in the study regions. Cases were patients whose peripheral blood counts and bone marrow histology met accepted diagnostic criteria[2]; each diagnosis was confirmed by a panel of haematologists blinded to drug exposures. Controls matched for age and sex were selected from among patients admitted to the same hospitals within 3 months for reasons judged to be independent of antecedent drug use--for example acute trauma.[2 3] Data on exposure to chloramphenicol were obtained by interview and included detailed...

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Gale Document Number: GALE|A53499431