Protein Co-Factors are Essential for High-Affinity DNA Binding by the Nuclear Factor KB ReIA Subunit

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From: Biochemistry(Vol. 57, Issue 20)
Publisher: American Chemical Society
Document Type: Report
Length: 69 words

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Abstract :

The study shows that purified recombinant nuclear factor ?B (NF-?B) RelA dimers bind specific ?B DNA sites with an affinity significantly lower than that of the same dimers from nuclear extracts of activated cells, suggesting that additional nuclear cofactors might facilitate DNA binding by the RelA dimers and suggest that the RelA-AD and multiple cofactor proteins function cooperatively to prime the RelA-DBD and stabilize the RelA:DNA complex in cells.

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Gale Document Number: GALE|A542240786